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Báo cáo y học: "Structural and functional characterization of human apolipoprotein E 72-166 peptides in both aqueous and lipid environments" pot

Báo cáo y học:

Báo cáo y học: "Structural and functional characterization of human apolipoprotein E 72-166 peptides in both aqueous and lipid environments" pot

... apoE- (72-166) peptides in PBS and also in the presence of DHPC, SE experiments we re performed. The SE and SVdata were combined and globally fitted to a multiplediscrete species model using SEDPHAT. ... positive ly correlates with the increasingconcentration of DHPC.Protein -lipid interactions and Protein-LDLR binding of ApoE- (72-166) ProteinsTo identify and compare the lipid binding ability of ... the in vitrobinding experiment of apoE(-) mice VLDL with theapoE proteins was analyzed using zone electrophoresis,which can separate the lipoproteins by their charge [43]. In these experiments...
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Báo cáo y học: " Genome-wide functional analysis of human 5’ untranslated region introns" ppsx

... represented by the red line while genes with short 5’UTR introns are represented by the blue line. The vertical linerepresents the top 5% of mean expression level of all genes. (d) Total 5’UTR intron ... divided by the presence of 5’UTR introns and by the number of tissues in which expression was detected. The number of tissues in whichexpression was detected was independent of the presence of 5’UTR ... analysis. RefSeq IDs correspond-ing to genes in the hypervariable hla-locus were simi-larly represented multiple times in the RefSeq collection. In these cases, only the version in the reference...
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Báo cáo y học: "Is there an association between anti-TNF monoclonal antibody therapy in rheumatoid arthritis and risk of malignancy and serious infection" ppt

... occurred during the – presumed openlabel – period of follow up. They did not attempt to calculateincidence rates (e. g. per 1000 person-years of exposure),given the difficulty in ascertaining the ... cancers(9/35), and a further four were identified within 6 weeks of starting therapy. Even excluding these cases, the increasedrisk compared with the comparison arms was still present,especially because ... serious adverse events were not identical to thoseused in the original published trials, because the authors tookadditional steps both to verify the nature of the events and toinclude events...
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Báo cáo y học: " Genome-wide comparative analysis of the Brassica rapa gene space reveals genome shrinkage and differential loss of duplicated genes after whole genome triplicatio" potx

... deletion, because it is more likely to recombine and less likely to have a severe phenotype when one redun-dant gene is deleted. Fewer tandem duplicate genes in the Brgenome may, therefore, be attributable ... topericentromeric heterochromatin gaps.The genome coverage of the gene-rich Br sequences was esti-mated by representation in two different datasets: expressedsequence tag (EST) sequences and ... demonstrated extensive syn-teny between the genomes, and provided clear evidence of arecent WGT event in the Brassica lineage. Our results signif-icantly expand on previous observations of synteny...
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Báo cáo y học: "Circadian phase-shifting effects of a laboratory environment: a clinical trial with bright and dim light" ppsx

... non-photic zeitgebers, including the imposed sleep-wakecycle, social cues, and activity/rest. There is evidence thatthe sleep-wake cycle is a potent zeitgeber; this effect maybe independent of the light-dark ... volunteers in the present studywere asked to maintain their usual sleep-wake and dailyroutines. These routines were often quite erratic, whichmight have rendered the circadian system more sensitiveto ... of insomnia were also recorded. Mean baseline sleep levelswere calculated, and have been reported previously [1].Baseline Mood AssessmentThe subjects' depressed moods were assessed on two days(usually...
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Báo cáo y học: " A retrospective quality assessment of pre-hospital emergency medical documentation in motor vehicle accidents in south-eastern Norway"

... manuallyrecording the same time data in the ambulance records.We registered the frequencies of completion of thesepatient encounter times, both in the electronic EMCCrecords and in the ambulance ... [23,24]. In our study, only one-half of patient encounter times were electronically transmittedback to the EMCC by the EMS services, yet these timepoints were documented in three out of four ... and the National Competence Centre of Emergency Medicine. Weare grateful to Professor Petter Andreas Steen for invaluable discussions on theconcept and design of the study as well as for revision...
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Tài liệu Báo cáo khoa học: Mapping the functional domains of human transcobalamin using monoclonal antibodies pptx

Tài liệu Báo cáo khoa học: Mapping the functional domains of human transcobalamin using monoclonal antibodies pptx

... all Metbonds in the TC sequence were cleaved completely, weobtained also a number of joined peptides, forinstance, peptides 4–5 and 10–11, which comprised thesequences between Met residues ... quarter of the full-lengthsequence.Antigenic properties of the synthetic peptides Two synthetic peptides of 30 residues PA and PBwereproduced (see Experimental procedures). They imitatedsequences ... the proteolytic fragmentsgenerated in t he yeast expression systemThe TC y expressed in yeast resolved into three bandsby SDS ⁄ PAGE. The major band corresponded to thefull-length protein of...
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Báo cáo y học: "Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis" ppt

... light-emitting oxidation of luciferin byluciferase in the presence of extremely low levels of ATP. Aftercollecting the chondrocytes by scraping, cells were centri-fuged for 10 min at 500 × g in ... series of ethanol solutions and infiltrated with xylene and before beingembedded in paraffin and cut into 6-µm sections. Sectionswere deparaffinized through sequential immersion in xylene and ... chondrocyte energy production,we measured the free ATP levels of cultured chondrocytesunder normoxic and hypoxic culture conditions. In controlchondrocytes, the levels of free ATP in hypoxia were...
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Báo cáo y học: "’Choosing shoes’: a preliminary study into the challenges facing clinicians in assessing footwear for rheumatoid patients" pot

... differences in patients’ preference of footwear style and type. The current study used a self-reported questionnaire to identify footwear style basedupon postural stability and falls prevention. ... reflecte d in the current study in the higher use of sandals.Despite the benefits of therapeutic footwear that havebeen previously reported [9,28-31], this type of footwearwas not widely worn ... severe level of foot impairment and disability [20].Footwear assessmentAn objective assessment of footwear was carried out bythe examiner, to ascertain the type and appropriateness of the...
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Báo cáo khoa học: An inserted loop region of stromal ascorbate peroxidase is involved in its hydrogen peroxide-mediated inactivation pot

Báo cáo khoa học: An inserted loop region of stromal ascorbate peroxidase is involved in its hydrogen peroxide-mediated inactivation pot

... membranes. Both isoforms are involved in the water–water cycle, asystem to scavenge reactive oxygen species in chloro-plasts and dissipate excess excitation energy of photo-systems [2]. The ... brokenline. Fe, nitrogen, oxygen and the cation near Trp265 are shown in cyan, blue, red and magenta, respectively. Residue numbers refer to stro-mal APX of spinach; see Fig. 1. These structures ... thanwhen an excess amount of hydrogen peroxide isexogenously added, and we could determine the half-time of the inactivation quantitatively.Whereas recombinant APX-B retained its initialactivity...
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