... thusleads either to arrest of cell cycle progression andrepair of the DNA breaks or, if the damage is tooextensive, to death of the cell by apoptosis, thus ensur-ing the maintenance of genomic ... damage, thereby promotingATM-dependent signaling [23]. Domains similar to the ATM-binding domain of Nbs1 are also found in ATRIP and Ku80 and are required for the interaction of these proteins with ... NH2-terminally truncatedNbs1 protein that contains an intact Mre11-bindingdomain. Differences in the nature of the Nbs1 muta-tion, as well as in the dose of radiation administered to NBS cells,...