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Báo cáo y học: "A role of ygfZ in the Escherichia coli response to plumbagin challenge" pdf

Báo cáo y học:

Báo cáo y học: "A role of ygfZ in the Escherichia coli response to plumbagin challenge" pdf

... tested ygfZ pQE-ygfZC228A 30 Not tested ygfZ pQE-ygfZC228S 40 Not tested ygfZ pQE-ygfZC228M 30 Not tested ygfZ pQE-ygfZY229A 30 Not tested ygfZ pQE-ygfZT230A 40 Not tested ygfZ pQE-ygfZG231A ... ing a role of ygfZ involved in the degrada-tion of plumbagin. YgfZ and SodA independently required for resolving plumbagin toxicitySince both ygfZ and sodA were found critical for E. coli to resolve ... possibly to accelerate the breakdown of plumbagin. Determining the ygfZ- dependent metabolites of plumbagin To confirm the plumbagin degradation happened in Ecoli, an effort was made to i dentify any...
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Báo cáo y học: "Current role of surgery in small cell lung carcinoma" pot

... of the evolution of the surgical management of small celllung cancer up to the present.Surgery Revived The role of surgery was revaluated after the introduction of the TNM staging system. The ... continue to be in favor of surgery as part of a combined modality treatment in patientswith SCLC. The revaluation of the role of surgery in this group of patients is based on clinical dataindicating ... dissemination. As a result, systemicchemotherapy, with or without radiotherapy, has beentypically accepted as the cornerstone of therapy in SCLC[1]. Initially surgery was the treatment of choice...
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Báo cáo y học: "A modified surgical technique in the management of eyelid burns: a case series" potx

... copy of the written consent isavailable for review by the Editor -in- Chief of thisjournal.AcknowledgementsWe sincerely appreciate the superb assistance of Cheltus Cheyuo MD of the Feinstein Institute ... cases into one case series because the surgicalmanagement of the eyelid injuries was the same,although the systemic managements of thes e patien ts asdifferent according to the injury area ... skin for future graft contracturewhile still preserving the ability to close the eye ade-quately. We widen the grafting area by separating andloosening the musculus orbicularis oculi, gaining...
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Báo cáo y học: "Antiviral therapy of HCV in the cirrhotic and transplant candidate"

... relatively high-dose interferon/ribavirin therapy in their cohort of 30 patients awaiting transplantation in Spain in an effort to reduce viral load at the time of LT. [17] When the investigators ... against Cirrhosis), is a multicenter study of the potential benefit of prolonged peginterferon therapy in mitigating the progression of fibrotic liver disease. [8] In this study, 391 of the ... hemoglobin > 10 g/dL and platelets > 35,000/mL. Growth factors were allowed in the management of therapy-induced cytopenias. The investigators estimated that “one fourth to one sixth of the...
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Báo cáo Y học: Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation docx

Báo cáo Y học: Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation docx

... ahomology model of human PXR in order to identifyresidues that were likely to be involved in ligand binding.Since the initiation of this study the crystal structure of the human receptor has ... fractions. The protein content of the nuclear and cytoplasmicfractions were determined by amino-acid analysis. 250 lL of 6MHCl with 0.5% Phenol was added to each of the samples (5 lL) and the hydrolysis ... known to be critical for coactivator binding and thereby activation.Replacing the histidine with an alanine in the humanreceptor creates a void, which is surrounded by the hydrophobic side chains...
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Báo cáo khoa học: Dual role of Nbs1 in the ataxia telangiectasia mutateddependent DNA damage response ppt

Báo cáo khoa học: Dual role of Nbs1 in the ataxia telangiectasia mutateddependent DNA damage response ppt

... thusleads either to arrest of cell cycle progression andrepair of the DNA breaks or, if the damage is tooextensive, to death of the cell by apoptosis, thus ensur-ing the maintenance of genomic ... damage, thereby promotingATM-dependent signaling [23]. Domains similar to the ATM-binding domain of Nbs1 are also found in ATRIP and Ku80 and are required for the interaction of these proteins with ... NH2-terminally truncatedNbs1 protein that contains an intact Mre11-bindingdomain. Differences in the nature of the Nbs1 muta-tion, as well as in the dose of radiation administered to NBS cells,...
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Báo cáo Y học: Thermal stability of peroxidase from the african oil palm tree Elaeis guineensis pdf

Báo cáo Y học: Thermal stability of peroxidase from the african oil palm tree Elaeis guineensis pdf

... enzymatic assays. The spectralparameters as monitored by ellipticity changes in the far-UVCD spectrum of the enzyme as well as the increase in tryp-tophan intensity emission upon heating, together ... The reheating scan revealed that the only effect of the first scanwas to decrease the peak intensity by a scale factordetermined by the difference in the amounts of proteinundergoing denaturation, ... the use of the whole Lumry–Eyring kinetic model [18]. Therefore, to analyse the irreversible thermal denaturation of proteins,Correspondence to V. L. Shnyrov, Departamento de Bioquı´mica y Biologı´a...
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Báo cáo y học: "Genetic control of disease in an experimental model for Sjögren’s syndrome" pdf

... Aec2contain genes that control development of SjS. In the present study, the investigators produced recombinantinbred lines by crossing the C57Bl/6 and C57Bl/6.NOD-Aec1Aec2 strains. A recombinant inbred ... controlling development of autoimmune exocrino-pathy in the NOD mouse and by reducing one of these regionsconsiderably, Nguyen et al. in a recent issue of Arthritis Researchand Therapy propose candidate ... hereditary and environmental factors. The disease is characterized by lymphocytic infiltration and inflam-mation in the salivary and lacrimal glands, leading to oral and oculardryness. To understand...
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Báo cáo y học: "A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANK" pps

... cell staining in the synovium and at the front of bone erosions. Furthermore, there was increased expression of RANK and its ligand RANKL in the inflammatory cells, in inflamed synovium and in articular ... cofactor with other pro-inflam-matory cytokines such as IL-1, TNF-α and IL-17 in mediat-ing cartilage/bone destruction [9,18,19]. When these pro-inflammatory cytokines are overexpressed in ... role for these potent cytokine com-binations in the joint destruction characteristic of inflamma-tory arthritic diseases.Competing interests The author(s) declare that they have no competinginterests.Authors'...
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Báo cáo y học: "A description of a knowledge broker role implemented as part of a randomized controlled trial evaluating three knowledge translation strategies" potx

... months following initiation of the intervention. The in- depth assessments also allowed for tailoring of the KBservices over the full duration of the study by identifyingat baseline the knowledge, ... poli-cies. The three main goals of the regional workshops were to: present the results of the systematic reviews disseminatedas part of the intervention in the RCT, facilitate discussionconcerning the ... guideline, and/or program evaluation. The KB's role was to assist participants in critically appraising the qual-ity of the evidence, and if the evidence was of high quality, to help identify...
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