Quantitative evaluation of motor function before and after engraftment of dopaminergic neurons in a rat model of Parkinson''''''''s disease ppt

Báo cáo y học: "Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain"

... significantly shorter in the CCI rats compared with sham controls. Mechanical allodynia and thermal hyperalgesia in- duced by CCI was attenuated by intrathecal adminis-tration with TLR4 -siRNA (p<0.05, ... Conclusions/Significance: These findings suggest that suppression of TLR4 mediated by intrathecally administered siRNA may be a new strategy for the treatment of neuropathic pain. Key words: Toll-like receptor ... transfection reagent (Neuromics, Edina, MN, USA) was administered intrathecally once daily for 7 days, starting from 1 day before CCI surgery. Evaluation of tactile allodynia and thermal hyperalgesia...

Báo cáo hóa học: " Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke" ppt

... this article as: Sun et al.: Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke. Journal of Translational ... Tracking of BrdU-labeled neural stem cells at passage six in the ischemic brain of rat having undergone cell therapy for fourweeks. A: a representative coronal section of a transplanted rat ... both the NSCcultures and the CSF of the rats. The immunochemical staining for MHC in brain sections and the enzyme-linkedimmunosorbent assay of CSF were carried out in sham-operated rats and rats...

báo cáo hóa học: " Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson''''s disease" potx

... dopamine (DA) cell loss in a rat model of PD. We used the intrastriatal administration of 6-hydroxydopamine(6-OHDA) that induces a retrograde neuronal damage and death, which progresses over weeks.Animals ... TNFalpha and baxmRNA in the striatum and induces apoptosis of dopaminer-gic neurons in hemiparkinsonian rats. Brain Res 2004,996:237-245.50. Adams FS, LaRosa FG, Kumar S, Edwards-Prasad J, ... Parkinson'sdisease. J Neurochem 2002, 81:1285-1297.12. Castano A, Herrera AJ, Cano J, Machado A: Lipopolysaccharideintranigral injection induces inflammatory reaction anddamage in nigrostriatal dopaminergic...

báo cáo hóa học: " Inhibition of NF-κB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia" docx

... AccessResearch Inhibition of NF-κB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemiaManu Jatana1, Shailendra Giri1, Mubeen A Ansari1, Chinnasamy ... Gilg AG, Sekhon C, Singh I, SinghAK: Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke. J Neurosci ... injury in rats via down-regulation of theinflammatory mediators NF-κB and iNOS. Thus, inhibit-ing the 5-LOX /NF-κB pathway holds therapeutic potentialto attenuate inflammation-mediated brain...

báo cáo hóa học: " CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson’s disease" pot

... article as: Zhang et al.: CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson’s disease. Journal of Neuroinflammation 2011 8:154.Submit ... 8:154http://www.jneuroinflammation.com/content/8/1/154Page 2 of 12 RESEARCH Open Access CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson’s diseaseShi Zhang1†, Xi-Jin Wang1†, ... midline, and 7.8 mm below the dura). The microinjection coordinatesused were obtained from a rat brain atlas by Paxinos and Watson. The injection was made at a rate of 1 μl/min using a 10 μl Ham...

Nghiên cứu khoa học nông nghiệp " COMPARISON OF HARVESTING DATA BEFORE AND AFTER PROJECT IMPLEMENT " potx

... 1 APPENDIX 5. COMPARISON OF HARVESTING DATA BEFORE AND AFTER PROJECT IMPLEMENT A. Harvesting data of smallholder farmers after three-year period CARD 026/VIE-05 project implement Variety: ... 5 B. Harvesting data of smallholder farmers before CARD 026/VIE-05 project implement Variety: OM2718Cooperative: Tan Thoi; Time:12/2006 - 03/2007; Winter-Spring crop Field drying Harvesting ... Phat; Data collected: 03/2009 Field drying Harvesting date No. Smallholder farmers Area (ha) Sowing method Sowing date Harvesting method Day(s) No Drying method Expected Actual Harvesting...

Báo cáo khoa học: "Role of mucosal mast cells in visceral hypersensitivity in a rat model of irritable bowel syndrome" ppt

... and simultaneouslymeasuring the concomitant increase in arterial pulse rate(tachycardia) from caudal artery using a non-invasive pulsetransducer (MLT125R, AD Instruments, Australia). TheAWR ... animage analyzing software. Loss of intracellular granules,with stained material dispersed diffusely within the laminapropria, was taken as an evidence of MMC degranulation[5]. The number of ... thatthe degranulation of MMC is an important pathophysiologicalfactor in visceral hypersensitivity associated with IBS. In experimental animals, the role of MMC degranulation in visceral hypersensitivity...

Báo cáo y học: "Abnormal costimulatory phenotype and function of dendritic cells before and after the onset of severe murine lupus" pot

... production of cytokines, and increased T cell stimulatory capacity before and after the onset of the disease [14].In our study we analyzed DCs in the original NZM2410 and NZB-W/F1 mice before and after ... No 2Research articleAbnormal costimulatory phenotype and function of dendritic cells before and after the onset of severe murine lupusLucrezia Colonna1, Joudy-Ann Dinnall1, Debra K Shivers1, ... evi-dent only after the onset of the disease, the overexpression of CD40 precedes the onset of lupus and is sustained even dur-ing the course of the disease. We therefore propose that the decreased...

Quantitative evaluation of motor function before and after engraftment of dopaminergic neurons in a rat model of Parkinson''''s disease ppt

... Quantitative evaluation of motor function before and after engraftment of dopaminergic neurons in a rat model of Par-kinson's disease Journal of Biomedical Science 2010, 17:9 Chuang et al. Journal ... gait changes in rats after unilateral 6-OHDA lesioning and dopaminergic neuron grafting. Some of the dynamic and static parameters were altered in ratswith 6-OHDA-induced lesions including paw ... and reproduction in any medium, provided the original work is properly cited.Research Quantitative evaluation of motor function before and after engraftment of dopaminergic neurons in a rat...

Báo cáo y học: "Estimation of lung vital capacity before and after coronary artery bypass grafting surgery: a comparison of incentive spirometer and ventilometry" pps

... AccessEstimation of lung vital capacity before and after coronary artery bypass grafting surgery: a comparison of incentive spirometer and ventilometryAreli Cunha Pinheiro1, Michelli Christina Magalhães ... subsequent assessment a comparison of averages before and after CABG surgery was performed and itwas observed that there were not significant disparit iesin DVC averages analysis (Table 2).Bland Altman ... measures of central tendency and dispersion and expressed asaveragesandstandarddeviation. Dichotomous or categorical variables wereevaluated with frequency measures and presented aspercentages....

Báo cáo y học: "Gender-based reciprocal expression of transforming growth factor-β1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis" ppsx

... citation purposes)Journal of InflammationOpen AccessResearchGender-based reciprocal expression of transforming growth factor-β1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced ... results mayindicate an interplay among components of the endocrinesystem, especially the hypothalamic-pituitary-adrenal(HPA) axis that regulates circadian rhythm and stressresponse with paracrine ... G, Ravani SA, Tang Y, Akhurst R, Wakefield L,Barcellos-Hoff MH: Latent transforming growth factor-betaactivation in mammary gland: regulation by ovarian hor-mones affects ductal and alveolar...

Báo cáo y học: " Ultrastructural changes of the intracellular surfactant pool in a rat model of lung transplantation-related events" pdf

... demonstrated that the alterations of intracellu-lar surfactant were significantly associated with earlypostoperative oxygenation and total intubation time[26]. The intracellular surfactant appears ... stored in lamellar bodies (Lb) can be distinguished from the intra-alveolar surfactant pool. The aim of this study was toinvestigate ultrastructural alterations of the intracellular surfactant pool ... clinical lung transplantation affecting both short-and long-term morbidity and mortality of patients [1,2]. Surfactant alterations in both the intra-alveolar and intracellular surfactant system have...

Báo cáo y học: "Kinematic and dynamic gait compensations in a rat model of lumbar radiculopathy and the effects of tumor necrosis factor-alpha antagonis" ppsx

... Copyedited and fully formatted PDF and full text (HTML) versions will be made available soon.Kinematic and dynamic gait compensations in a rat model of lumbar radiculopathy and the effects of tumor ... early stages of lumbar radiculopathy in the rat, and that, gait metrics and dynamics may be valuable measures in pre-clinical studies evaluating drug effectiveness. Abbreviations ANOVA: ... percentage stance times of 0 and a gait symmetry variable of approximately 0.5. A shift in either of these variables would indicate a shift away from balanced, symmetric gait. For the statistical...

Báo cáo y học: "Cellular infiltrates and injury evaluation in a rat model of warm pulmonary ischemia–reperfusion" pot

... identical pattern of alveolar oedema in a function of time by using a histological examination (H&E) and assessment by wet : dry ratio. An important increase of alveo-lar oedema was observed after ... of reperfusion in a model of acutelung injury, which was defined by quantifying apoptosis and alveolar oedema.Materials and methodsAnimalsMale inbred Wistar rats (mean weight 225 g), obtained ... delivertoxic radicals that damage pulmonary endothelium directly orindirectly by activating caspase-3, which results in apoptosis[1,2]. Second, they can damage pulmonary endothelium and parenchyma by delivering...

Báo cáo y học: "Effect of magnesium sulfate administration on blood–brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study" ppt

... permea-bility and leads to the formation of brain edema in septic rats. Magnesium administration attenuated the increased BBB per-meability and caused a reduction in brain edema formation in our ... blood–brain barrier permeability during insulin-induced hypoglycemia in rats. Can J Physiol Pharmacol 2001, 79:793-798.5. Esen F, Erdem T, Aktan D, Kalaycý R, Cakar N, Kaya M, Telci L:Effects of magnesium ... maintainedthe baseline plasma magnesium levels in magnesium- treatedseptic rats.Quantitative estimation of the EB dye revealed that sepsis sig-nificantly increased BBB permeability as measured...

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