... proteins. Thus, the MEN1 ⁄ LEDGF-interactingdomain linked to DNA-binding domains (AT-hook and MT domain) becomes disconnected from the PHDdomains, the FYRN domain, the transactivatingdomain, ... 2010)doi:10.1111/j.1742-4658.2010.07608.xThe increasing number of chromosomal rearrangements involving the human MLL gene, in combination with differences in clinical behavior and outcome for MLL-rearranged leukemia patients, ... active AXIN ⁄ GSK3signaling leads to the destruction of SMAD3, and thusinterferes with transforming growth factor (TGF)b sig-naling [44]. In line with this, GSK3 has recently beenidentified in a...