... USA
Jossey-Bass, 989 Market Street, San Francisco, CA 9 410 3 -1 7 41, USA
Wiley-VCH Verlag GmbH, Pappalallee 3, D-69469 Weinheim, Germany
John Wiley & Sons Australia Ltd, 33 Park Road, Milton, Queensland ... virus spreads to the target organ (e.g. in measles, rubella and varicella).
Local symptoms are due to the cell damage caused by virus replication in the
target organ leading to...
... mutation
rates. There are proofreading enzymes already in the cell to correct errors in
DNA -to- DNA transcription, but not to correct RNA -to- DNA or RNA -to-
RNA molecular events. The first clinical trial ... NEURAMINIDASE
The new anti-influenza drugs have a significant advantage compared with
amantadine of inhibiting both influenza A and B viruses. Relenza is rather
poorly absorbed...
... Associated
neurological disease (radiculomyelopathy, cranial nerve involvement) occurs
rarely and may lead to residual paralysis.
Coxsackie B has also been associated with idiopathic dilated cardiomyo-
pathy. ... coryza, flushed face,
epistaxis, photophobia, anorexia or vertigo. Croup among small children is a
relatively common feature (see also Chapter 11 ).
Differential diagnosis. A r...
... (MUMPS)
LABORATORY DIAGNOSIS
Antigen-capture measles-specific IgM antibody assays are available and
are highly specific and sensitive. Confirmation of the diagnosis by
demonstration of a 4-fold rise ... prodromal rhinitis
and hoarseness. The patient has dysphagia and a higher fever than in viral
croup and a toxic appearance. The epiglottis appears enlarged and inflamed on
inspection. Respir...
... Phosphonoacetic acid
(PAA), adenine arabinoside (ara -A) , desciclovir, sorovudine (BV-ara-U) and
interferon -a and -g have demonstrated an ability to inhibit oropharyngeal
shedding, but significant clinical ... cancer
and AIDS patients, zoster may become generalized and life-threatening.
Haematogenous dissemination to internal organs may occur as in varicella
(Chapter 19 ). As in vari...
... hosts be treated with
ganciclovir or foscarnet. Clinical efficacy data are not available.
Prophylaxis is not available.
LABORATORY DIAGNOSIS
Diagnosis of roseola is clinical. HHV-6 can be detected ... Southeast Asia but also in central Asia, Africa and central America.
Sporadic cases also occur in the same areas. Seroepidemiological studies in
these areas indicated that up to 25% of the p...
... potential explosive
and not as a biological. Numerous clinical trials have sho wn that prophylactic
administration as a tablet given twice a day will prevent influenza A (H3N2,
H1N1 or H2N2) clinical ... REPLICATION THAT ARE SUSCEPTIBLE TO INHIBITORS
Target Antiviral Virus/infection
(1) Virus adsorption Dextran sulphate
CD4 (receptor)
HIV -1
HIV -1
(2) Viral penetration and...
... the organiza-
tions involved usually have staff available to answer questions. In
addition, all malpractice carriers, ever anxious to avoid litigation, and
knowing that ethical canons can be introduced ... circumstance whereby an attorney would have to
report a therapist for an ethical mistake or violation. We have always
made ourselves available for consultation when a mental healt...
... rise above the minutiae and short-term focus of day -to- day
organizational life, and plan and coordinate the collective and individ-
ual activities of their staff. This can be a significant part ... organizational and cultural
change 298
9 Innovation and organizational learning 347
10 Managing employee knowledge and
intellectual capital 396
11 Leadership and people management in
hig...