Báo cáo y học: "The promise and limitations of population exomics for human evolution studies" doc
Báo cáo y học: "The promise and limitations of population exomics for human evolution studies" doc
... variation and evolutionary history, but there are signicant challenges to overcome before this becomes a reality.© 2010 BioMed Central LtdThe promise and limitations of population exomics for human ... events (in units of thousands of years, kyr) and population sizes are indicated. (b) The site frequency spectrum for sample sizes of 50 and 2,000 chromosomes. (c) Average value of Tajima’s D ... clearly more desirable and important to develop [33].Challenges and caveats for population exomics Although exome datasets remove many of the biases and limitations that have plagued previous population...
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Báo cáo y học: "The promise and reality of personal genomics" pot
... likely to be easy to both genotype and sequence. The sensitivity of SNP and indel detection in repetitive or copy-number-variable regions will be lower. Finally, a non-trivial proportion of any ... systems - but no explicit comparison of the two versions has yet been published.MinireviewThe promise and reality of personal genomicsBryndis Yngvadottir, Daniel G MacArthur, Hanjun Jin and ... uncertainty is added by the fact that most of the common variants currently associated with complex traits and diseases have been ascertained and studied only in populations of European origin, and...
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Báo cáo Y học: The processivity and fidelity of DNA synthesis exhibited by the reverse transcriptase of bovine leukemia virus pot
... Virology 259, 176–189].In the p resent study, we have studied in vitro two features of the DNA polymerase activity of BLV RT, t he processivity of DNA synthesis and the fidelity of DNA synthesis. ... processivity and fidelity of DNA synthesis exhibitedby the reverse transcriptase of bovine leukemia virusOrna Avidan, Michal Entin Meer, Iris Oz and Amnon HiziDepartment of Cell Biology and Histology, ... much lowerprocessivity of 24%.The fidelity of DNA synthesisAll our previous studies with a variety of retroviral RTshave shown that the parameters for fidelity of DNAsynthesis in vitro (i.e....
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Báo cáo y học: "The use and abuse of commercial kits used to detect autoantibodies" ppsx
... high level of security, of scrutiny and of standardization, and under good labora-tory practices and quality control. Many of these compa-nies subscribe to and offer postmarketing qualityassurance ... chain of production, use and application of autoantibody test kits.198PatientThe ongoing demands of quality control and quality assur-ance are highly dependent on the availability of prototypesera ... attendsthe delayed diagnosis of a systemic rheumatic disease, itis difficult to understand why low-cost and high-qualityautoimmune serology is not given a higher priority by thehealth care system.It...
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Báo cáo y học: "The identification and characterization of a novel protein, c19orf10, in the synovium" docx
... healthy synovial membrane consists of a thin layer of fibroblast-like synoviocytes (FLSs) and macrophages. Thesecells produce glycosaminoglycans such as hyaluronic acid and lubricating glycoproteins ... staining of a hyperplastic RA synovial lin-ing cell layer. This staining was typical of most areas of RA synovium where the lining was hyperplastic. (h) An area of an RA synovial lining layer that ... technical assistance of Patty Sauder for production of the murine monoclonal antibodies, Miranda Ma for assistance in immunohistochemistry, and Keng Wong for samples of cells and synovial fluids....
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Báo cáo y học: " The yin and yang of chromatin spatial organization" ppt
... article and many more, are likely be important in dynamically shaping the spatial environment and organization of the genome.Specialized transcriptionfactoryTranscription factoryRegulatory proteinNuclear ... Fullwood MJ, Liu MH, Pan YF, Liu J, Xu H, Mohamed YB, Orlov YL, Velkov S, Ho A, Mei PH, Chew EG, Huang PY, Welboren WJ, Han Y, Ooi HS, Ariyaratne PN, Vega VB, Luo Y, Tan PY, Choy PY, Wansa KD, Zhao ... Gene Expression for their help and advice, and also thank Lyubomira Chakalova, Claire Joyce and Nicole Shoaf for critical reading of the manuscript. This work was supported by the Medical Research...
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Tài liệu Báo cáo Y học: Structural diversity and transcription of class III peroxidases from Arabidopsis thaliana docx
... ortholog of HRPC2 (91% aminoacid identity). Shinmyo et al. [64] have studied the promoteractivity and wound-induction of HRPC and -E types, and of AtPCa and AtPEa. Most remarkably, C2, and only C2,responded ... a nonglycosylated triplet at position Asn70 [48].The majority of the peroxidases carry one or two putativeglycans. Seven appear to be nonglycosylated. Therefore, thehigh number of glycans found ... Differentialactivity and structure of highly similar peroxidases. Spectroscopic,crystallographic, and enzymatic analyses of lignifying Arabidopsisthaliana peroxidase A2 and horseradish peroxidase...
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Báo cáo y học: "The renal metallothionein expression profile is altered in human lupus nephriti" doc
... b).Figure 1Localization of metallothionein (MT) isoforms I + II in healthy kidneys and in lupus nephritisLocalization of metallothionein (MT) isoforms I + II in healthy kidneys and in lupus nephritis. ... the time of biopsy for allSLE patients: sex, age at time of biopsy, age at time of SLEdiagnosis, date of first renal biopsy, date of onset of nephritissymptoms (defined as the date of the first ... Department of Pathology, Aarhus University Hospital, and Professor Niels Marcussen, Department of Pathology, Odense University Hospital, for kindly donat-ing some of the renal biopsy specimens on...
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Báo cáo y học: "omparative Efficacy and Tolerability of 5-Loxin® and Aflapin® Against Osteoarthritis of the Knee: A Double Blind, Randomized, Placebo Controlled Clinical Study"
... Golakoti T, Sarma KV, Dey D, Raychaudhuri SP. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee. Arthritis ... accounting for 25% of visits to primary care physicians. It is estimated that 80% of the population will have radiographic evidence of OA by age 65 years, although only 60% of those will be symptomatic ... clinical trial. Evaluations of physical activity and pain scores, serum biochemistry, hematology, and urine biochemistry were done at baseline (day 0) and on days 7, 30, 60 and 90 during follow up....
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Tài liệu Báo cáo Y học: Phosphatidylinositol synthesis and exchange of the inositol head are catalysed by the single phosphatidylinositol synthase 1 from Arabidopsis docx
... novosynthesis, catalysed by phosphatidylinositol synthase (EC2.7.8.11), also known as CDP-diacylglycerol (DAG)/myo-inositol 3-phosphatidyltransferase, and an exchange reac-tion whereby the ... phosphatidylinositol; PtdOH, phosphatidicacid; CDP-DAG, CDP-diacylglycerol; CMP, cytidinemonophosphate; CTP, cytidine triphosphate.Enzymes: phosphatidylinositol synthase or CDP-diacylglycerol/myo-inositol ... in enzymaticactivity. One possibility therefore is that EDTA couldchelate inhibitory ions, whose identity remains unclear,maybe with a higher affinity than for Mn2+.If it is clear, for the...
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