... to common
tumor suppressor genes shared by many cancer types like
RB1 and TP53, many tumor suppressor genes are specific
to a particular tumor type and/ o r cell type that originate
the tumor. Deficiency ... 11:R114
http://genomebiology.com/2010/11/11/R114
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RESEARC H Open Access
Systematic detection of putative tumor
suppressor genes through th...
... of
the drug is hydrogen-bonded to the two O2 atoms of the
thymine bases of the central AT steps. Nitrogen atoms
N3(D) and N7(D) bridge N3(adenine) and O2(thymine)
atoms of opposite strands. Furthermore, ... amino-group
pyramidalization.
The contacts of the atoms O1(D) and N1(D) at the other
side of the drug are more complicated. The interaction
energy with...
... teaching in the
field of Allergy and Clinical Immunology and was well respected as a
physician, teacher and colleague. The 2010 Canadian Society of Allergy and
Clinical Immunology Dr. David McCourtie ... trials and other studies published on
either prophylaxis or therapy of hereditary angio edema
and some of these produ cts have changed licensure sta-
tus in various co...
... articular chondro-
cytes and as the main precursor for the synthesis of ECM gly-
cosaminoglycans in cartilage [35,36]. The inhibition of
proteoglycan synthesis in OA chondrocytes by HNE (data not
shown) ... activity is primarily impor-
tant for the observed event. On the other hand, the inhibition
of mNADP
+
-ICDH, an important regulator of the citric acid
cycle, by HN...
... gives the reader the
advantages of a traditional review text.
Overview of part one of The Scientific Basis
of Rheumatology: A Decade of Progress
Biology and methodology
The contribution of Foxwell ... arthritis. Chen and Tuan [2] discuss the potential
involvement of MSCs in the pathophysiology of degenerative
joint disease and explore the prospects of MSC...
... contexts
over the past 30 years. [21]. These include the Theory of
Reasoned Action, the Theory of Planned Behavior, the
Health Belief Model and Social Cognitive Theory. [31-34].
Implicit in the combination ... asking
questions? Finally, self-efficacy reflects whether a person
perceives that they have the necessary skills and abilities
to perform the behavior if they real...
... conceived the study, carried out the in vivo experi-
ments and flowcytometry, performed the statistical analy-
sis and drafted the manuscript. FR participated in the
design and coordination of the ... Offringa and has been described previously [14].
The 9H10 antibody was administered as 100 µg/mouse
i.p. on the first day together with DC vaccination and 50
µg/mouse...
... study is under way.
Introduction
The prevalence of systemic lupus erythematosus (SLE) varies
with age, gender, and ethnicity, and the highest rates occur in
young adult women, particularly of ... 2 g daily.
The duration of follow-up of patients on MMF was generally
between 6 and 36 months, and average follow-ups were gen-
erally of 1 year or longer. None of the stu...
... underestimate because our cur-
rent analysis is limited by the quality and quantity of the
therapeutic data available. Our representations of chemi-
cal structure and drug therapeutic use rely on public
databases, ... struc-
tural similarity (295 and 37 pairs in the heterozygous and
homozygous datasets, respectively). Of these pairs, 74%
and 90% in the heterozygous...
... suggested by the
‘ crown-stem’ model [18-20]. Even if the position of
the root of the eukaryotic tree is between Excavata and
the other supergroups, the split of the lineage with
plants and the lineage ... leading to the conclusion that
early eukaryotes had significantl y more gene duplicatio n
Figure 1 Alternative views of the eukaryotic phylogeny and
the...