... bepossible to bypass this defect using a gene therapyapproach. Such approaches, while not providing a ‘fountain of youth’, may someday enhance the quality of life of the aged by increasing their resistance ... quality of the humoral response of aged individuals.Study of the GC reaction in healthy aged humans isimpractical for obvious reasons. Nonetheless, the products of the GC reaction, namely antibodies, ... deficiency. Elderly individuals present withincreased susceptibility to, and severity of, infectiousdiseases and decreased vaccine efficacy. More recently,however, the status of the aged-immune system...