Báo cáo y học: "Out of the sequencer and into the wiki as we face new challenges in genome informatics" doc

Báo cáo y học: "Incidence of Ocular Zoonoses referred to the Inflammatory and Autoimmune Ocular Diseases Service of the University of Parma - Italy"

... cases and therefore the real incidence of Lyme disease is unknown. In Italy, Lyme disease has been subject to mandatory notification since 1990, but there is likely an underestimation of the real ... information on the incidence of zoonoses in this territory. Two hundred and seventy six new cases of ocu-lar inflammatory disease were examined in this Ser-vice in 2007. Forty one (15%) patients ... wide. The mountains of the Appennine range divide Parma Province from Tuscany and from Ligury, and Po river flows through its territory. The territory of Parma Province presents two types of...

Tài liệu Báo cáo Y học: Targeting of malate synthase 1 to the peroxisomes of Saccharomyces cerevisiae cells depends on growth on oleic acid medium pptx

... [33], the issue of the partitioning of the glyoxylate cycle in cells grown under fattyacid-medium conditions has hitherto remained open. We showed here that one of the key glyoxylate-cycleenzymes, ... dehydrogenase activity speci®cally involved in the glyoxylate cycle is attributed to the cytosolic isoformMdh2p [7]. The suggestion of an extra-peroxisomal locationfor the yeast g lyoxylate cycle ... sources, yeast c ells rely on the gly-oxylate cycle. This process is based on some of the same enzymes as those of the citric acid cycle. H owever, the steps in whic h decarboxy-lations occur in the...

Báo cáo Y học: Mammalian HSP60 is quickly sorted into the mitochondria under conditions of dehydration docx

... cortex and medulla in the rat kidneys after 3 and 5 days of waterrestriction. We investigated the quantity of HSP60 in the cyto-plasm and mitochondria by immunoblotting. No changes in the quantity ... papilla of rats that were water restricted but the protein was increased in the mitochondria of the rat kidneypapilla. We also analysed binding of the protein to the signalsequence of HSP60 using ... HSP60 wasrecognized by both the cytoplasmic and the mitochondrialHSP60, an antibody against the signal sequence of HSP60was recognized only by the cytoplasmic HSP60 in the immunoblotting analysis....

Báo cáo y học: "Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis" ppt

... level, they are activated by similar factorssuch as interleukin-1 [37], whereas plasmin and trypsinactivate the precursors of both proteins [38]. In addition,MMP1 and MMP3 interact at the protein ... with the Ratingen score (P = 0.044). The presence orabsence of the SE explained 29% of the variance of the Ratingen score, independently of the location at DR4,indicating an association of the ... stimulation by inflammatorycytokines; they degrade key components of cartilage and bone matrix [6]. MMP1 expression occurs in cells of the invading front of the activated RA synovial tissue [7] and iscorrelated...

Báo cáo y học: "Biology of recently discovered cytokines: Discerning the pro- and anti-inflammatory properties of interleukin-27" pptx

... regulating the kinetics and intensity of infection induced immunity.Many of the cytokines produced to combat pathogenicchallenge are also characteristic of chronic inflammatorydisorders. Accordingly, ... [43]. In contrast, T. gondii and T. cruzi aredisseminating infections that induce strong innate immuneresponses and high serum levels of inflammatorycytokines [43]. In these infectious diseases, ... response to various inflammatory stimuli and imply a role for this cytokine in the regulation of infection-induced immunity.Because they promote inflammatory processes, the production of heterodimeric...

Báo cáo y học: "Expression of cytokine mRNA and protein in joints and lymphoid organs during the course of rat antigen-induced arthritis" potx

... for any cytokine in anyorgan at any time point.Discussion The present study documents that, in AIA, elevation of IL-1β in the SM as well as elevations of IL-6 mRNA in SM,inguinal LN, and spleen ... respectively) peaked from 6 hours to day 3 in the spleen. Increases of the corresponding proteins were significant in comparison with day 0 only in the case of IL-2 (day 6). By day6 (transition to the ... the arthritogen, and on days 1, 3, and 6 of the disease, the lat-ter time point marking the transition to the chronic phase.For the sake of clarity, individual cytokines are assigned tomonokine- and Th1-/Th2-like...

Báo cáo y học: "Reliability of computerized image analysis for the evaluation of serial synovial biopsies in randomized controlled trials in rheumatoid arthritis" pps

... evaluation of ST. The major advantage of DIA is standardization of image acquisition and processing, minimizing variance, and the ability to quantify the actual stained area together with staining intensity ... sections wererandomly analyzed by computer-assisted image analysis (Fig.1). For all markers, 18 high-power fields were analyzed. The images of the high-power fields were analyzed using the Qwinanalysis ... with an interval of 4weeks in between (OB1 t0 and OB1 t1, respectively). Todetermine the inter-rater reliability, acquisition of images and analysis were performed independently by two other experi-enced...

Báo cáo y học: "Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis" potx

... in the zygapophyseal joints and restriction of spinal mobility [6,7].Acute inflammation in the spine associated with AS, as detected by magnetic resonance imaging (MRI), has beendescribed in ... Veys EM: Involvement of the zygapophy-seal joint in ankylosing spondylitis: relation to the bridgingsyndesmophyte. J Rheumatol 1999, 26:1738-1745.6. Simkin PA, Downey DJ, Kilcoyne RF: Apophyseal ... edema.Correlation of histopathology with MRIInterstitial bone marrow edema as detected by histopathology in the zygapophyseal joints of the lumbar spine was found byMRI in three of eight patients with AS...

Báo cáo y học: "Lack of association or interactions between the IL-4, IL-4Rα and IL-13 genes, and rheumatoid arthritis" pptx

... measures the amount of destruction by assessing 32joints, including 16 areas in both hands (eight joints in eachhand), eight areas in both wrists (four joints in each wrist) and eight joints ... conceived and designed the study. All authors contrib-uted to the acquisition of the samples or study data. IM per-formed genotyping as well as all data analyses. All the authorswere involved in the ... site of the IL-4R genewas associated with rapidly erosive RA during the first 2 years of disease, and that this was independent of other risk markerssuch as HLA-DRB1 and autoantibodies [12].In...

Báo cáo y học: "Influence of Cyclodextrin Complexation with NSAIDs on NSAID/Cold Stress-Induced Gastric Ulceration in Rats"

... The principal mechanism of action of all NSAIDs is the inhibition of the biosynthesis of prostaglandins by blocking the activity (selectively and/ or non-selectively) of two isoforms of cyclooxygenase ... respectively. The corresponding decreases in the case of piroxicam were 89.2 and 80.3%, respectively. In this study, administration of each of the two NSAIDs coupled with hypothermic and restraint ... was sectioned and submitted totally. They were processed overnight and then embedded in paraffin. The paraffin blocks were sectioned and the slides were stained with a standard haematoxylin...

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