... suggestive of a structural effect of HSF4 on
chromatin. In the absence of HSF4, histone H3K9
methylation is induced and HSF1 binding is reduced,
indicating that HSF4 facilitates HSF1 binding via
chromatin ... of cHSF2,
mHSF2 and rHSF2 are associated with nuclear locali-
zation within the developing neural tube [3,62,121].
In addition, mHSF2 is associated with DNA binding
in...
... deletion in one of
the active-site loops of Pc_Cel7D (Fig. 6). The role
of Arg240 in binding to O5 and O6 in the +1 site
is thus assumed by Arg251 in Tr_Cel7A. The main-
chain atoms of Arg251 ... for
Tr_Cel7A in complex with lactose, but some points
seem clear in a comparison of the two enzymes. In
Pc_Ce7D, the flexibility of the Arg240 side chain is an
important...
... implants to the appendix
from routine interval appendectomy in 210 patients with
intraabdominal malignancy; accounting for 0.95%. One
case was secondary to a sigmoid cancer with limited peri-
toneal ... study were to evaluate the incidence of synchro-
nous appendiceal neoplasm in patients with resectable
CRC in a university hospital, and to determine the clinical
signifi...
... on
conformation of inhibitor main chain. Thus, different
inhibitors differ not only in t he binding affinity, bu t a lso
in the degree o f freedom of the inhibitor inside the binding
tunnel. Some s pecial inhibitors ... adaptation of not only the inhibitor to
the protease but also of the protease to the inhibitor.
Comparison of inhibitors side chains
Boc groups at P
2
of SE...
... side-chains of K89, residue 90 and residue 97 are shown. The dis-
tances between the e-amino groups of K89 and K90, and between the e-amino group of K90 and the guanidino group of R97, in the ... structure of the 6·-RNase HI protein was deter-
mined at 2.5 A
˚
resolution. The main chain fold and interactions of the
side-chains of the 6·-RNase HI protein were basically iden...
... stress-inducible member of the CCAAT ⁄
enhancer-binding protein family, can act as an
upstream activator of DR5 in certain types of cancer
cells [19,20]. In line with our previous findings [21],
we ... differ-
ences in their sensitivity to these treatments, with two of the six cell lines
revealing no significant induction of cell death in response to TRAIL
alone. Inter...
... an indirect role to
engage residues in the loop for binding interactions with the
phosphonate group of fosfomycin (or with the phosphate
group of phosphoenolpyruvate during normal catalysis). In
order ... into the molecular mechanism driving the
formation of the covalent C115–fosfomycin adduct. A
conservative exchange of K22 to arginine maintains fosfo-
mycin binding,...
... the total. Of these
the word order was Subject — Predicate in 1282
instances, 43.99% of the total; the word order
was Predicate — Subject in 245 instances,
8.41% of the total, the ratio being ... 17. 02% of the total. Of
these, the word order was Subject — Predicate
in 399 instances, 13.69% of the total; the word
order was Predicate — Subject in 97 instances,
3. 33%...
... antibody A in the presence of
increasing concentrations of bilirubin. BSP uptake was
assayed to track the progress of the antibody-induced
inhibition. Figure 5A shows that increasing bilirubin
concentrations ... anthocyanin sequestration, is a flavonoid-
binding protein. Plant Physiol 123, 1561–1570.
24 Grotewold E (2004) The challenges of moving chemicals
within and out of cells...
... levels of HydA1 increased up to
about 48 h, corresponding to the time when H
2
-production
rates are high (Fig. 3, top). In contrast to HydA1, the levels
of the HydA2 transcript increased up to 24 ... hydrogenases in
algal metabolism. This hypothesis will be investigated in the
future.
The HydA2 protein is expressed during anaerobic
induction
In order to determine whethe...