Báo cáo y học: "The case for cloud computing in genome informatics" pot
Báo cáo y học: "The case for cloud computing in genome informatics" pot
... unusually involved analysis in reasonable running time and possibly being scooped by a competitor. In the latter case, they waste money purchasing and maintaining a system that they are not using ... time may have come for genome informatics to migrate to the cloud. © 2010 BioMed Central LtdThe case for cloud computing in genome informaticsLincoln D Stein*R EV IEW*Correspondence: lincoln.stein@gmail.com ... and the community. Academic clouds may in fact be a better long-term solution for genome informatics than using a commercial system, because genome computing has requirements for high data read...
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Báo cáo y học: "The quest for the Holy Grail: a disease-modifying osteoarthritis drug" doc
... raise several points.First, reality does not always match the theory. Manybiological pathways remain to be discovered, although theymay be critical because they interact with a potential drugEditorialThe ... the MMPs, afamily of zinc-containing proteinases, are key enzymes in thebreakdown of extracellular matrix. In vitro and in vivo experi-ments confirmed that this was also true for the cartilagematrix. ... encoding novelproteins or enzymes in specific in vitro systems. This potentialtarget is then tested in vivo in a translational researchprocess. Clinical trials are then conducted to determinewhether...
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Báo cáo y học: "The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now" potx
... function, including proteins involved in the Wnt signaling pathways [85], may therefore constitutefurther interesting markers for the future.Importantly, however, achieving low disease activity orremission ... employing 28 joint counts, theSimplified Disease Activity Index and the Clinical DiseaseActivity Index (reviewed in [9]) – have been shown useful for following disease activity and for serving ... imaging and ultrasound,may allow new insights and may contribute interestinginformation on disease activity or even outcome [93-95].More information is presently needed, and the search for...
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Báo cáo y học: "The quest for a biomarker of circulating osteoclast precursors" docx
... regarding the central importance of phagocytosisto human physiology, which culminated in a Noble Prize andlaid the groundwork for the field of innate immunity at theopening of the last century ... phenotype in vitro was identified by investigators in John Hamilton’slaboratory and may represent an immature monocyte that hasthe ability to replicate in target tissues [7].Circulating monocytes ... analysis ofcarboxyfluorescein succinimidyl ester (CFSE)-labeled cells.The authors state that functional analysis of proliferation mayprovide a better tool for identification of specific monocytesubsets...
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Báo cáo Y học: The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis doc
... transit proteins during spermio-genesis, is rich in both arginine and cysteine. The cysteinesulfhydryls in protamine must form disulfide bond topackage DNA into small sperm head during the maturationprocess. ... cysteine, andglycine, via two ATP-con suming s teps involving c-g lut-amylcysteine synthetase ( cGCS) and glutathione synthetase.The other constitutes a recycling system involving GRwhich reduces ... firstglance, may be attributed to the unique protein metabolism in these cells. Histone is rich in the basic amino acids, lysineand arginine, but contains no cysteine. Protamine, which isreplaced for...
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Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx
... deacetylcephalosporin C; DACS, deacetylcephalosporin C synthase; DAOC, deacetoxycephalosporin C; DAOCS,deacetoxycephalosporin C synthase; Dnase 1, deoxyribonuclease 1; EDTA, ethylenediaminetetraacetic ... bridgewith the carboxyl group of the a-aminoadipoyl- side-chainof penicillin N (1), with arginines 74 and 75 apparentlyplaying a less important role in side-chain binding. Takentogether, the results ... 2 )in Streptomyces clavuligerus [1–7]. The subsequent hydroxyla-tion of DAOC to give deacetylcephalosporin C (DAC 3)iscatalysed by a closely related oxygenase, deacetylcephalo-sporin C synthase...
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Báo cáo y học: "The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma" potx
... gastrointestinal absorption ofingested corticosteroids. In summary, this case d escribes a patient who likelyhas a lymphocytic variant of hypereosinophilic syndromethat resulted in eosinophilic ... diagnosis bydetecting both infiltrating eosinophils and t he presenceof eosinophil degranulation when conventional eosinand hematoxylin staining of the tissue was not inter-preted as being significant ... propensity to “ stick” to virtually anysubstratum as well as its near insolubility in environ-ments at neutral pH limits its utility for immunohist o-chemistry [12]. Moreover, these intensely staining...
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Báo cáo y học: "The prevalence of mental disorders in adults in different level general medical facilities in Kenya: a cross-sectional study" pot
... appropriately. However, in Kenya, there are only 68 psychiatrists serving a populationof approximately 34 million. Less than half of them areinvolved in active clinical work, and they mainly practice in ... such aspolygamy since women especially may have felt resentfulabout sharing a partner, although this study did notinquire for gender differences in depressive symptoms.Patients living in rural ... studyand was involved in drafting the manuscript and revisingit critically for intellectual content. LIK participated in acquisition, analysis and interpretation of data and wasinvolved in...
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Báo cáo y học: "The Short Anxiety Screening Test in Greek: translation and validation" ppsx
... Sinoff G, Ore L, Zlotogorsky D, Tamir A: Short Anxiety Screening Test - abrief instrument for detecting anxiety in the elderly. Int J GeriatrPsychiatry 1999, 14:1062-1071.25. American Psychiatric ... screening tool, within primary care settings.Thus the SAST could be used to obtain preliminaryinformation with regard to anxiety symptoms, whichwould then need to be followed-up by a detailed inter-view ... tool for screening for anxiety symp-toms in older people. Due to its brevity and ease ofadministration, the SAST could be a useful instrument for routine practical use within Greek primary caresettings.Additional...
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Báo cáo y học: " The ''''antisocial'''' person: an insight in to biology, classification and current evidence on treatmen" pps
... of psy-chotherapy in psychopathy was assessed in a meta-analy-sis by Salekin et al. [65]. They analysed 42 interventionalstudies for individuals classified as psychopathic (unfor-tunately, ... reinforcement and therefore involved in learning)and the ventromedial prefrontal cortex (activated in tasksinvolving moral decision making) are also thought to playa key role in experiencing ... empathy (ICD-10 only).2. Incapacity to maintain enduring relationships (ICD-10 only).3. Repeated lying and conning others for personal bene-fit and pleasure (DSM-IV only).4. Impulsivity and...
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