... nemertodermatids).
Acoels were originally grouped within the phylum
Platyhelminthes but have recently been placed at a key
position at the base of the Bilateria on the basis of new
molecular data [9] (Figure ... complexity [3-7]. It is not
clear, however, how exactly novel miRNAs evolve and
what roles they have in the establishment of tissue
identity. According to th...
... multiplicity of different
biological pathways. For the most part, the organization and
function of these aging-related pathways remain poorly
understood. In particular, the role of most longevity genes
in ... <
10
-6
). For the Budovskaya et al. study [21], subnetwork
seeds were highly enriched for known longevity genes, and
the set of all subnetwork genes was slightly en...
... anticipated. These factors significantly
reduced the power of the study. Based on their findings, the
authors estimate that more than 100 hospitals would be
needed to show the 30% difference they sought. ... goal of identifying
and treating patients early in the course of their illness is
preferable to waiting until more serious signs and symptoms
have developed. Certain...
... replacement of Gly261 by Ala in mutant
G261A resulted in an enzyme with slightly lower stability.
On the other hand, in the double mutant G261A /Y2 69A the
additional replacement of Tyr269 by Ala restores ... although the HGGG loop was a
critical structural element for the catalytic efficiency of the
enzyme, the cold adaptation of the enzyme could not be
attributed to...
... the content of secondary structure only after the
disruption of the native tertiary structure of RNase A
(Figs 2–4). Interestingly, the preservation of the tertiary
structure coincides with the ... triflu-
oroethanol the proteolytic susceptibility of RNase A
strongly increases, which coincides with the disruption of
the tertiary structure of the RNase A mo...
... studying the catalytic
efficiency for these mutants in the diaphorase reaction, all
of them yield values very close to those of the wild-type
enzyme at the different ionic strengths assayed (within ... FNR the side-chain of E139 might influence the
properties of the flavin, assuming some of the functions
carried out by E301 in the wild-type enzyme [22]. In this
contex...
... complement of chromosomes.
The fidelity of chromosome transmission is enhanced not
only by the geometry of stable centromere–MT interac-
tions, but also by the action of a centromere-based
regulatory system ... way, the critical connections that hold sisters
together from S phase through early mitosis are literally cut
by Ômolecular scissorsÕ in the form of Esp1/separase at...
... for the
clinician to be comfortable with the side-effect profile and be able to discuss potential safety concerns regarding these therapies.
Among the safety concerns with the use of INCs are the ... for the clinician to be comfortable
with the- side effect profile and be able to discuss potential
safety concerns regarding these therapies. Among the
safety concerns wit...
...
1
Institute of Psychiatry, University of Bologna, Italy,
2
Department of Psychology, Catholic University, Milan, Italy and
3
Department of
Psychiatry, San Raffaele Scientific Institute, Milan, Italy
Email: ... bipolar
disorder of Mr. A daughter strengthen the genetic hypoth-
esis. On the contrary, only Mrs. B mother aunt was
affected by depression and anxiety, pharmacologica...
... for
ankylosing spondylitis and rheumatoid arthritis, an absence of
fibromyalgia, and a temporal increase in the prevalence of
gout. What should we make of all of these estimates and why
are they important ... rheumatic
diseases vary in prevalence by age. An additional source of
Editorial
Comparing the prevalence of rheumatic diseases in China with
the rest of the world...