... present study shows that ER-α gene haplotype may be associated with primary knee OA, andgenetic variations in the ER-α gene may be involved in OA.Keywords: estrogen receptor, haplotype, knee ... receptor-α gene haplotype is associated with primary knee osteoarthritis in Korean populationSheng-Yu Jin*1, Seung-Jae Hong*2, Hyung In Yang3, Sang-do Park3, Myung-Chul Yoo4, Hee ... threepolymorphisms in the ER-α gene (intron 1 T/C, intron 1 A/G andexon 8 G/A) and primary knee OA. Genotypes of the ER-α gene polymorphism were determined by PCR followed by restrictionenzyme digestion (PvuII...