New Concepts in Diabetes and Its Treatment - part 4 ppsx

... Regular and intermediate-acting insulin before breakfast, regular insu-lin before lunch and supper, and intermediate-acting insulin at bedtime (4 daily insulin doses).(d) Regular insulin before ... insulins)Pattern of insulin treatment (episodic therapy and CSII may increase insulin immunogenicity)Genetic factors (HLA-A2-B 44 and HLA-B 4 4- DR7 predispose to immune complications ofinsulin ... injections,regular and intermediate-acting insulin before breakfast, regular insulin beforesupper and intermediate-acting insulin at bedtime. This 3 times daily insulindose regimen is useful in diabetic...

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New Concepts in Diabetes and Its Treatment - part 1 ppt

... (lean and/ or trained sub-jects) and elevated (?15 U/ml) in insulin-resistant subjects. It should bepointed out that an apparent normal insulin level in insulin-resistant diabeticsubjects indicates ... changed in type 2patients, suggesting preserved -cell sensitivity in these patients.Insulin Secretion in Type 2 Diabetes Both impaired insulin action (insulin resistance) and reduced insulin secre-tion ... M3>a type of muscarinic re-ceptor; PIP2>phosphatidylinositol -4 , 5-P; PKA>protein kinase A; PKC>protein kinase C;PLC>phospholipase C.23Insulin Secretion and Its Pharmacological...

New Concepts in Diabetes and Its Treatment - part 2 docx

... MAP-K>mitogen-activated protein kinase; PC-1>an ecto-proteinkinase probably interfering with insulin receptor tyrosine kinase; PI3-K>phosphatidyl-inositol-3 kinase; PIP2>phosphatidylinositol -4 , 5-P; PKA>protein ... threonine (the serine/threonine-spe-ciﬁc protein kinases). The receptor -subunit can be phosphorylated on serine,threonine and tyrosine residues and possesses intrinsic protein-tyrosine kinaseactivity. ... proteins; Ins>insulin receptor; IP3>inositol-1 ,4, 5- trisphosphate; IRS1>insulin receptor substrate-1; IRS2>insulin receptor substrate-2;M>muscarinic receptor; MAP-K>mitogen-activated...

New Concepts in Diabetes and Its Treatment - part 3 docx

... (a) the rapid-acting, (b) the intermediate-acting and (c) the long-acting insulin. (a) The rapid-acting insulin preparations includethe regular insulin as well as the semilente insulin which is ... to insulin and adjusting the pH. (c) The long-acting insulin prepara-tions include the ultralente insulin, obtained by modifying, during the prepara-tion, the pH of a mixture of zinc and insulin ... insulin contains threonine, isoleucine and threonine at thesame sites. Porcine insulin is more similar to human insulin inasmuch as ithas the same amino acids as bovine insulin at positions A-8...

New Concepts in Diabetes and Its Treatment - part 5 pdf

... simultaneous determinations every 4 6 h of glycemia, insulinemia and C-peptide during fasting periods of 24, 48 and 72 h. In insulinoma, glycemia falls while C-peptide and insulinemiaremain near-unmodiﬁed. ... receptorsmetabolism in childrenSepsisIntake of leucine in leucine-sensitiveInsulin or insulin-releasing drugschildren(sulfonylureas, pentamidine, quinine)Newborn hypoglycemia (ﬁrst hours of ... possible, and to use a rapid-acting insulin analogue beforethe main evening meal.Hypoglycemia in Insulinoma and Extrapancreatic Tumors In insulinoma patients, surgery is the elective treatment, ...

New Concepts in Diabetes and Its Treatment - part 6 pot

... diabeticretinopathyrequiringphoto-coagulation treatment and intraretinal microvascular abnormalities not requiring treatment New vessels requiring photocoagulation Intraretinal microvascular abnormalities not treatment ... caused by disturbances in thediabetic metabolism in pregnancy. Since the risk for developing diabetic retino-pathy during pregnancy increases with increasing duration of diabetes, diabeticwomen ... the blood-retina barrier and therefore remains inside the bloodstream. However, in exu-dative diabetic maculopathy the blood-retina barrier is broken down and areaswhere ﬂuorescein leaks out...

New Concepts in Diabetes and Its Treatment - part 7 pdf

... morbidity, and mortality in non-insulin-dependent diabetes mellitus. Lipopro-teins and coronary heart disease in non-insulin-dependent diabetes mellitus. J Diabetes Complica-tions 1997;11:137– 141 .Lopes-Virella ... lipoproteins in non-insulin-dependent diabetes mellitus. Diabet Med 1997; 14( suppl 3):67– 74. De Man FH, Cabezas MC, Van Barlingen HH, Erkelens DW, de Bruin TW: Triglyceride-rich lipoproteins in non-insulin-dependent ... Lowering in Diabetes Comment on Normal Lipoprotein MetabolismHepatic production of VLDL is regulated by insulin (and the anti-insulinhormones) at diﬀerent sites. In fact, insulin, by inhibiting...

New Concepts in Diabetes and Its Treatment - part 9 pdf

... thesestudies.The Scandinavian Simvastatin Survival Study (4S) included 4, 444 patientswith a recent myocardial infarction or angina pectoris and an increased fastingserum-cholesterol level in the range ... overview. Diabetes 1997 ;46 (suppl 2):58–61.Dr J. Shaw, Department of Medicine (M7), Manchester Royal In rmary,Manchester M13 9WL (UK)Tel. +44 161 276 44 52, Fax +44 161 2 74 4 740 , E-Mail jshotham@hotmail.com217Foot ... nephropathy 5 .4 234Gæde/PedersenChapter XVIBelﬁore F, Mogensen CE (eds): New Concepts in Diabetes and Its Treatment. Basel, Karger, 2000, pp 218–228 Erectile Dysfunction in Diabetes and Its Treatment M....

Mass Transfer in Multiphase Systems and its Applications Part 4 pot

... transducing part, impeller displacement transducing part and signal processing part. In the fluid force transducing part, the strain generated during operation in a copper alloy coupling having ... consumption and solid suspension performance of large - scale impellers in gas - liquid - solid three - phase stirred tank reactors. Chemical Engineering Journal, 97, 10 3-1 14, doi:10.1016/S138 5-8 947 (03)00 14 8-7 ... published by Sutherland in a famous paper that introduced the notion of flotation kinetics, Sutherland (1 948 ). 2 .4 Modeling of flotation in a bubble column The kinetic model based on gas-liquid mass...

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