Báo cáo y học: "Physical function, disease activity, and health-related quality-of-life outcomes after 3 years of adalimumab treatment in patients with ankylosing spondylitis" potx
Báo cáo y học: "Physical function, disease activity, and health-related quality-of-life outcomes after 3 years of adalimumab treatment in patients with ankylosing spondylitis" potx
... Safety and efficacy of readministration of infliximab after longterm continuoustherapy and withdrawal in patients with ankylosing spondylitis.J Rheumatol 2007, 34 :510-515.25. Baraliakos X, Brandt ... JC: Adalimumab reduces pain, fatigue, and stiffness in patients with ankylosing spondylitis: results from the Adalimumab TrialEvaluating Long-Term Safety and Efficacy for Ankylosing Spondylitis ... Reductions in health-related quality of life in patients with ankylosing spondylitis and improvements with etanercept therapy. Arthri-tis Rheum 2005, 53: 494-501. 23. Braun J, Sieper J: Ankylosing spondylitis....
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Báo cáo y học: " Dysfunctional interferon-α production by peripheral plasmacytoid dendritic cells upon Toll-like receptor-9 stimulation in patients with systemic lupus erythematosus" doc
... all SLE patients were taking hydroxychloroquine, and the inhibition of TLR9 byresidual hydroxychloroquine cannot fully explain the abroga-tion of IFN-α observed in one-third of SLE patients ... [mg/day]) 41 (95 .3) ; 13. 0Hydroxychloroquine (n [%]) 34 (79.1)Azathioprine (n [%]) 4 (9 .3) Cyclosporin (n [%]) 1 (2 .3) Mizoribine (n [%]) 4 (9 .3) Mycophenolate mofetil (n [%]) 3 (7.0)aSystemic ... important insight into the pathogenesis of SLE and the markedly increased incidence of certain viralinfections in SLE patients. In addition, our data indicate thatthe role of IFN-α is different in...
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Báo cáo y học: "Pravastatin Provides Antioxidant Activity and Protection of Erythrocytes Loaded Primaqe"
... pravastatin and primaquine exposed eryt-hrocytes. All groups of erythrocytes were fixed in buffered gluteraldehyde. Aldehyde was drained and rinsed 3 times each of 5 min in phosphate buffer and ... in the current studies upon loading to erythrocytes. The erythrocytes were classified into; control erythrocytes, erythrocytes incubated with either 2 mM of PS or 2 mM of PQ, and erythrocytes ... eryt-hrocytes were treated with 2mM of primaquine in the third group. And in the fourth group the erythrocytes were exposed to pravastatin plus primaquine 2mM. After 30 min, the erythrocytes...
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Báo cáo y học: "Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis" doc
... number of swollenjoints and with the Disease Activity Score 28 [33 -35 ].Hypersialylation is associated with a decrease in the specificcirculating DPPIV activity in RA patients, and the activitycould ... peptides,including systemic and locally acting neuropeptides, lympho-kines, cytokines and chemokines, contain an evolutionarilyconserved amino-terminal penultimate proline residue as aproteolytic-processing ... [28].Alterations in the DPPIV levels in SF may represent anincrease in the presence of attractin. Certainly, analysis of serum reveals an increase in attractin in RA patients with erosive disease, which...
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Báo cáo y học: " Hyperglycemia alters enzyme activity and cell number in spinal sensory ganglia" ppsx
... for clarity of presentation and comparison. Optical density values fall along a range of 0 representing minimal staining intensity (no staining) and 10 representing extremely dense staining (black).Enzyme ... overexpression of calmodulin in pancreatic β-cells) used in this study displays a well-char-acterized chronic hyperglycemia and hypoinsulinemiawithin days after birth. [5,6]. Ten (five OVE26 transgenic and ... used toexamine the impact of long-standing hyperglycemia and hypoinsulinemia on the distribution and activity of lyso-somal acid β-glycerophosphatase (AP), cytochrome oxi-dase (CO), and NADPH-diaphorase...
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Báo cáo y học: "Transfers to psychiatry through the consultation-liaison psychiatry service: 11 years of experience" pdf
... Soc Psychiatry Psychiatr Epidemiol 2001, 36 :38 1 -39 0.17. Hamada Y, Ohta Y, Nakane Y: Factors affecting the family sys-tem of patients with schizophrenia: a survey in the remoteisland of Tsusima. ... providing inpatient care,maintaining strong interaction with community psychiat-ric services and offering specialist services to the generalhospital wards either as part of the multidisciplinaryapproach ... history; such infor-mation included: lack of health insurance, lack of perma-nent residence or homelessness, prolongedunemployment, lack of any income. The severity of thepsychiatric and the...
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Báo cáo y học: "Gastro-tracheal fistula - unusual and life threatening complication after esophagectomy for cancer: a case report" potx
... radio-chemotherapy and transtho-racic en-bloc resection with extended mediastinal lym-phadenectomy[1]. The underlying pathophysiology tothis complication mainly consists of leakage of the anas-tomosis with ... condition and severity of symptoms, size and location of the fistula and managing team. Symptomsvary from mild coughing to more severe recurrent bron-cho-pneumonia and life-threatening mediastinitis. ... dayslater, after placing a Polyflex stent in the trachea, furtherfibrin glue was injected in the esophageal defect and theorifice was closed off with hemostatic clips. Use of fibringlue, with...
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Báo cáo y học: "Carotid intima-media thickness and endothelial function: useful surrogate markers for establishing cardiovascular risk in patients with inflammatory rheumatic disease" pdf
... against development of accelerated athero-sclerosis in chronic inflammatory diseases remains to bedetermined, but this is in intriguing possibility. It could explainwhy GCA mortality in very ... only carotid IMT. Based on these findings, wepropose that ultrasonographic assessment of the carotidartery should be performed in all patients with RA in order toidentify the subgroup of patients ... recently reported [2] that carotid artery IMT had goodability to predict development of cardiovascular events over a5-year period of follow up in 47 patients with RA withoutclinically evident...
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Báo cáo y học: "Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on" pps
... activation of con-served intracellular signaling proteins and pathways, inclu-ding NFκB, the mitogen-activated protein kinases, phospha-tidylinositol 3 kinases (PI3Ks) and the Janus tyrosine kinase(JAK)/signal ... glucocorticoid treatment Glucocorticoids (GCs) are invaluable therapeutic tools in the treatment of many chronic inflammatory diseases, includingasthma and RA. Recent findings in the study of inflammatorylung diseases demonstrate ... of HAT activity to HDAC activity may sensitize cells toinflammatory gene transcription via chromatin remodeling,may increase the DNA binding and activity of transcriptionfactors, and may increase...
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Báo cáo y học: "Hepatitis C Virus Serologic and Virologic Tests and Clinical Diagnosis of HCVRelated Liver Disease"
... alfa and ribavirin therapy and the HCV genotype should be systematically determined before treatment, as it determines the indication, the duration of treatment, the dose of ribavirin and the ... (A), genotypes 2 and 3 (B), and genotypes 4, 5 and 6 (C). Int. J. Med. Sci. 2006, 3 37 Chronic hepatitis C In patients with clinical or biological signs of chronic liver disease, chronic ... detection of 50 IU/ml or less 24 weeks after the end of treatment [18]. Initiation of therapy Only patients with detectable HCV RNA should be considered for pegylated IFN alfa and ribavirin combination...
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