Báo cáo y học: "Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis" ppsx
... 3
Research article
Negative association of the chemokine receptor CCR5 d32
polymorphism with systemic inflammatory response,
extra-articular symptoms and joint erosion in rheumatoid arthritis
Manuela ... the association of CCR5 d32 with the inflammatory
response, joint erosion, and DNASE2. In the early RA cohort,
CRP levels at...
... at the
C-terminus of CCR5 would interfere with the protein’s
ability to function as a chemokine receptor or HIV
coreceptor, we first determined the binding of MIP-1a to
the CCR5- myc-his expressing ... Groningen, the
Netherlands) in order to obtain a recombinant protein
containing the C-myc epitope followed by six histidines at
the C-terminus. A plasmid containing...
... concentrations in
combination with the presence of actin and gelsolin-actin
complexes in synovial fluids suggest a local consumption of this
potentially anti -inflammatory protein in the inflamed joint.
Introduction
Plasma ... clearing actin from synovial joints of rheumatoid arthritis patients with acute joint effusionProposed model of plasma gelsolin (pGSN) fu...
... joint.
Our findings are in agreement with the observation that
CXCR3, a cell surface receptor for the proinflammatory
chemokines inducible protein (IP)-10 and monokine
induced by interferon-γ ... Proinflammatory
cytokines that induce a high acute phase response also
favour the recruitment of a diverse memory T cell reper-
toire to the joint, independent of the antigen...
... Biol Ther 2003; 2: 491-9.
16. Huang S, Shao G, Liu L. The PR domain of the Rb-binding zinc
finger protein RIZ1 is a protein binding interface and is related
to the SET domain functioning in ... types of PRDMs have
been identified in humans [15, 18]. Most of them are
located near the N-terminal portion of the proteins
followed by zinc-fingers, and are involved...
... completely destroyed, and
ultrastructures could not be identified.
Biochemistry parameters
In the present study, the amylase levels in the
serum and urine were increased in the first 3 days and
the ... irregular, and bulky. A
narrow region w i t h inflammatory cell infiltration,
consisting primarily of lymphocytes and monocytes
sometimes with small number...
... the
catalytic site in the N-terminal domain of one subunit and
the substrate recognition site in the C-terminal domain of
the other face each other, thereby bringing together the
substrate-binding ... (Arg405, Lys407,
Lys413, Lys414, Lys422, Lys428, and Lys430) oriented in
the same direction with the heparin-binding domain at the
N-terminal end [14]. The ot...
... alignment of the
interdomain and autolysis loops of
mammalian chymotrypsins and trypsins.
The enzyme that was used in this study, rat
chymotrypsin B, is highlighted by bold type.
The loops are boxed and ... in the interdomain and autolysis loops
in the inactivation of chymotrypsin. At first, D-chymo-
trypsin and the interdomain and autolysis loop mutants wer...
... with binding resulting in receptor
dimerization, activation of the intrinsic receptor tyrosine
kinase, and initiation of intracellular signal transduction
[14]. Although the EGFR is the primary site ... standard
cysteine residue in the
DYANA library [53]. A pseudoatom
was included instead of the HG atom and a bridge was
formed by superimposition of the pseudo...
... other,
indicating a substantial perturbation of the axial symmetry
of the tensor, whereas axial symmetry, i.e. g
xx
% g
yy
<< g
zz
is typically found for type 2 sites. The grouping of the
g-values ... Egmond
1
and Martina Huber
3
1
Unilever Research Vlaardingen, the Netherlands;
2
University of Groningen, Laboratory of Biophysical Chemistry,
Groningen, the Nether...