... informa-
tive sets of genes whose expression changes during therapy
Editorial
Predicting the future of anti-tumor necrosis factor therapy
Cornelis L Verweij
Division of Inflammatory Disease Profiling, ... costs for therapy, there is
a strong need to make predictions on success before the start of
therapy. In the current issue of Arthritis Research & Therapy,
Hueber...
... anticipated. These factors significantly
reduced the power of the study. Based on their findings, the
authors estimate that more than 100 hospitals would be
needed to show the 30% difference they sought. ... goal of identifying
and treating patients early in the course of their illness is
preferable to waiting until more serious signs and symptoms
have developed. Certain...
... indepen-
dent of each other. Fluency was judged directly by
the assessors, while adequacy was meant to assess
the content of the sentence compared to a human
gold-standard. Yet, the assessments of the ... influenced by many
factors. The way the sentence fits in the con-
text of surrounding sentences is one obvious factor
(Barzilay and Lapata, 2008). Another well-known...
... although the HGGG loop was a
critical structural element for the catalytic efficiency of the
enzyme, the cold adaptation of the enzyme could not be
attributed to the presence of the Gly cluster ... G261A/
Y2 69A designed on the basis of side-chain packing criteria
from a modelled structure of the enzyme resulted in restor-
ation of the energy of activation to...
... the content of secondary structure only after the
disruption of the native tertiary structure of RNase A
(Figs 2–4). Interestingly, the preservation of the tertiary
structure coincides with the ... hydro-
chloride (GdnHCl), urea or elevated temperatures, they
destroy the tertiary structure of proteins which results in the
loss of enzymatic activity. Regarding the...
... when studying the catalytic
efficiency for these mutants in the diaphorase reaction, all
of them yield values very close to those of the wild-type
enzyme at the different ionic strengths assayed (within ... FNR the side-chain of E139 might influence the
properties of the flavin, assuming some of the functions
carried out by E301 in the wild-type enzyme [22]. In this
c...
... complement of chromosomes.
The fidelity of chromosome transmission is enhanced not
only by the geometry of stable centromere–MT interac-
tions, but also by the action of a centromere-based
regulatory system ... way, the critical connections that hold sisters
together from S phase through early mitosis are literally cut
by Ômolecular scissorsÕ in the form of Esp1/separase at...
...
n3
ha-1yr-1
for
the
typical
site.
The
95%
Cl
for
the
mean
GYC
for
the
site
ranged
from
±0.7
for
the
typical
site
to
±2.4
m3
ha-1yr-1
for
the
high
yielding
site.
The
range ...
the
sum
of
the
angles
to
the
horizon
at
the
8
cardinal
points
of
the
com-
pass)
was
the
single
most
significant
factor
affecting
productivity,
explaini...
... for the
clinician to be comfortable with the side-effect profile and be able to discuss potential safety concerns regarding these therapies.
Among the safety concerns with the use of INCs are the ... allergies are ‘ the most common
chronic condition in Canadians 12 years of age and
older.’’
1
In one study, 42% of children were diagnosed
with AR by the age of 6 years. The...
...
1
Institute of Psychiatry, University of Bologna, Italy,
2
Department of Psychology, Catholic University, Milan, Italy and
3
Department of
Psychiatry, San Raffaele Scientific Institute, Milan, Italy
Email: ... bipolar
disorder of Mr. A daughter strengthen the genetic hypoth-
esis. On the contrary, only Mrs. B mother aunt was
affected by depression and anxiety, pharmacologica...