... administration of a single cytokine is not representative forskewing of an immune response in < /b> which multiple cytokines are involved. HSPs probably not only increase IL-10 production byT cells, but ... controversial. On one hand,TLR stimulation on DCs can enhance IL-10 production bythem, and thereby induction of Tregs (Figure 2a). On the other hand, stimulation of TLRs on DCs can lead to inhibition of ... asdiscussed above.Altogether, as for vaccination, the combination of enhancingboth adaptive and innate immunity may be attractive forimmune therapy of arthritis. As discussed before, HSP60 maybe able...