Báo cáo y học: "Heat shock protein 60 reactive T cells in juvenile idiopathic arthritis: what is ne" pdf
Báo cáo y học: "Heat shock protein 60 reactive T cells in juvenile idiopathic arthritis: what is ne" pdf
... self-HSP60, while polyarticularpatients did not [65]. This finding suggests a correlationbetween disease severity and HSP60 reactivity of T cells in these patients, in the sense that reactivity to ... protection fromarthritis [64], as well as interference in ongoing arthritis[12]. The next obvious question is how this immunereactivity in experimental arthritis may relate to arthritis in humans.HSP60 ... may enhance thisresponse by inducing innate immunity through TLR triggeringat the same time.Preliminary data suggest that a combination of both TCR andTLR activation causes induction of Tregs...
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Báo cáo y học: "The expansion of CD4+CD28– T cells in patients with rheumatoid arthritis" potx
... manifestations.The association of CD4+CD28– T cells with diseasestatus has given rise to the hypothesis that these cells directly contribute to disease manifestations. Patients withnodulosis and extra-articular ... in the absence of a costimulatorypathway.CD4+CD28– T cells contribute to the cell infiltrate andexhibit increased survival after apoptotic stimuli. Resis-tance to apoptosis in CD28– T ... cells was in RA patients with limited joint manifestations. Signif-icantly higher numbers of CD28–lymphocytes werepresent in patients with advanced joint involvement andextra-articular manifestations.The...
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Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf
... of the wild-type protein and that loss of activity is associated either withperturbation of the native structure or local disruption ofthe metal binding or the active site.The point mutation ... exhibits an Eaalmost the same as in the caseofthenativeenzyme(Table1).Thermal inactivation of mutant and wild-type enzymes In order to investigate the effects of mutations on thestability of ... stability in an activity sense and not in athermodynamic sense. We therefore assume that even lowenzymatic activity is associated with a mutant that retains toa considerable extent the overall...
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Báo cáo Y học: Anti- and pro-oxidant effects of urate in copper-induced low-density lipoprotein oxidation pdf
... started, LPO was higher than that obtained in theabsence of urate (Fig. 1). In other words, urate is a pro-oxidant under these conditions. It is noteworthy that at themoment of urate addition, ... the urate catabolism pathway to elaborate otherantioxidative mechanisms susceptible to cope with the lossof the capability to synthesize ascorbate. Compared withother mammals, the strong increase ... ofurate or its synergistic effects with other antioxidants havebeen attributed to its ability to scavenge hydroxyl andsuperoxide radicals and peroxynitrite and to chelation oftransition metal...
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Báo cáo y học: " Intramuscular electroporation with the pro-opiomelanocortin gene in rat adjuvant arthritis" doc
... encephalomyelitis in Lewis rats, the animalmodel for multiple sclerosis, reported that administrationof the opioid antagonist naloxone markedly increases theseverity of the condition [27]. In our study, ... [25].Efficiency and toxicity are the two most important aspects in the search for potential pain gene therapies, with toxicityoften being the limiting factor. Because the gene encod-ing POMC has not previously ... except that, 30 minutes beforethe nociceptive test at 7 days after CFA injection, nalox-one (1 mg/kg) was administered intraperitoneally to deter-mine whether any analgesic effect was mediated...
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Báo cáo y học: "The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases" pot
... othersobserved that this cytokine protected T cells from apopto-sis [50,51]. We favor the hypothesis that TGF-β promotesthe death of mature Th1 and Th2 cells while protectingnewly generated regulatory T ... Central Ltd (Print ISSN 1465-9905; Online ISSN 1465-9913)AbstractRegulatory T cells prevent autoimmunity by suppressing the reactivity of potentially aggressive self- reactive T cells. Contact-dependent ... cellular hyporesponsiveness in achronic human helminth infection is mediated by Th3/Tr1-type cytokines IL-10 and transforming growth factor-betabut not by a Th1 to Th2 shift. Int Immunol 2000,...
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Báo cáo y học: "β Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases" potx
... anddocumentation of their in vivo potential was an importantnext step. In pursuit of this goal, recent studiesdemonstrated for the first time that the transfer of in vitrogenerated Treg into disease ... againstself-recognition-induced autoimmunity is accomplished in large part by the central deletion of autoreactive T cells during intrathymic development, this process is notperfect and self -reactive escapees ... there is a rapidengagement of this intracellular signaling pathway that is consistent with TGF-β as the link between these two cells and the impending functional inhibition manifested in theresponder...
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Báo cáo y học: " Predictors of infusion reactions during infliximab treatment in patients with arthritis" docx
... nonspecific symptoms.DiscussionThe main findings in the present study are that positive ANAstatus before the initiation of treatment with infliximab and useof infliximab without methotrexate in patients ... investigated. In summary, RA patients in whom ANA positive status is present at treatment initiation with infliximab and who aretreated without methotrexate are at increased risk for develop-ing infusion ... with caution because of limitedstatistical power. In our study, concomitant treatment withmethotrexate was used to a lesser extent in patients with SpAthan in patients with RA, probably because...
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Báo cáo y học: "Hand bone loss as an outcome measure in established rheumatoid arthritis: 2-year observational study comparing cortical and total bone loss" pot
... Kvien TK: Bone mineraldensity and frequency of osteoporosis in female patients withrheumatoid arthritis: results from 394 patients in the OsloCounty Rheumatoid Arthritis register. Arthritis Rheum ... Bone loss in unclassified pol-yarthritis and early rheumatoid arthritis is better detected bydigital x ray radiogrammetry than dual x ray absorptiometry:relationship with disease activity and ... statisti-cally significant.ResultsPatient characteristics at baseline and at follow-up are pre-sented in Table 1. The 215 examined patients in this study hadshorter disease duration (9 years...
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Báo cáo y học: "Prognostic factors of 10-year radiographic outcome in early rheumatoid arthritis: a prospective study" ppt
... activity throughout the 10-year follow-up but not with joint damage. This discrepancy with previousreports may be due in part to the early start of therapy withdisease-modifying anti-rheumatic ... not for citation purposes)Competing interestsThe authors declare that they have no competing interests.Authors' contributionsNC participated in acquisition, analysis and interpretation ... short but not long term.As mentioned in the results, in this study it was unfortunatelynot possible to carefully analyse the potential effect of corti-costeroids during the first years of the...
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