Báo cáo y học: "Human articular chondrocytes express 15-lipo

Báo cáo y học: "Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis" pdf

... matrix metalloproteinase (MMP)-1 and MMP-13 expression. Methods The expression levels of 15-lipoxygenase-1 and -2 were analyzed by reverse transcription PCR and Western blotting in chondrocytes, and by immunohistochemistry ... 1 Human articular chondrocytes express both 15-LOX-1 and 15-LOX-2Human articular chondrocytes express both 15-LOX-1 and 15-LOX-2. (a) Cho...

Ngày tải lên : 09/08/2014, 14:20

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Báo cáo y học: "Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13" ppsx

... catabolic activity [2]. In addition to inducing matrix degrading enzymes directly, these cytokines can also act by stimulating production of additional proinflammatory cytokines. IL-6 is among the cytokines ... analysis (data not shown). IL-7 binding assay For flow cytometry analysis, chondrocytes were removed from six-well dishes by trypsin digestion and for confocal micros- copy analy...

Ngày tải lên : 09/08/2014, 10:23

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Báo cáo Y học: Apolipoprotein E predisposes to obesity and related metabolic dysfunctions in mice pdf

... vein, and glucose levels were measured. Determination of plasma insulin and leptin levels Insulin and leptin levels in the plasma of mice were determined spectrophotometrically by ELISA (Linco/Millipore, Billerica, ... 9841–9853. 46 Weisgraber KH, Innerarity TL & Mahley RW (1982) Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine–arginine in...

Ngày tải lên : 17/03/2014, 17:20

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Báo cáo y học: "Human meniscus cells express hypoxia inducible factor-1α and increased SOX9 in response to low oxygen tension in cell aggregate culture" ppsx

... expression in articular chondrocytes aggregates. Prolyl 4-hydroxylase (P4H)α isoenzyme gene expression in cell aggregates of articular chondrocytes in 20% oxygen (white bars) and 5% oxygen (black ... Arnoczky SP: Gross and vascular anatomy of the meniscus and its role in meniscal healing, regeneration, and remodelling. In Knee Meniscus: Basic and Clinical Found...

Ngày tải lên : 09/08/2014, 10:20

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Báo cáo y học: "Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues" pptx

... leucine-rich proteoglycans (SLRPs) – including biglycan, decorin, fibromodulin, lumican and keratocan – play important linking, shape determining and matrix organizing roles [14-16]. These roles ... resistant to proteolysis than the other SLRPs or that fibromodulin degradation prod- ucts retaining the carboxyl-terminus may not be stably retained in the tissue and are lost into the s...

Ngày tải lên : 09/08/2014, 10:23

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báo cáo hóa học:" Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function" ppt

... post-culture by flow cytometry analysis (B). Expression of FoxP3 and CD25 were determined in freshly isolated CD4+ T cells (day 0) and after a 3-day stimu- lation with anti-CD3/CD28 Abs (C). Freshly isolated ... T cells induces expression of CD25 and Foxp3 associated with effector and memory phenotype differentiation PBMC were stimulated with bryostatin-1 (5 nM) and ion- omycin...

Ngày tải lên : 18/06/2014, 15:20

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Báo cáo y học: "Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action" pps

... MMPs increases in OA by either an increase in their own synthesis, an increased activation by their proen- zymes, or decreased activity of their inhibitors [29]. Pro- inflammatory cytokines, including ... involved in cartilage catabolism by inhibiting the synthesis of colla- gen and PG, enhancing MMP activity, reducing the synthesis of an IL-1 receptor antagonist by chondrocytes,...

Ngày tải lên : 09/08/2014, 01:21

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Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"

... complications including coronary heart dis- ease, retinopathy, nephropathy, and neuropathy [3, 4]. In addition, chronic hyperglycemia leads to progres- sive impairment of insulin secretion and to insulin ... they are not hydrolysed by β-glucosidases in the intestine and can be adminis- tered orally [27]. Therefore, the aim of the present study was to evaluate the inhibitory effec...

Ngày tải lên : 26/10/2012, 10:04

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Báo cáo y học: "Plasmatic B-Type Natriuretic Peptide and C-Reactive Protein in Hyperacute Stroke as Markers of Ct-Evidence of Brain Edema." pptx

... Kistorp C, Raymond I, Pedersen F, Gustafsson F, Faber J, Hildebrandt P. N-terminal pro-brain natriuretic peptide, C-reactive protein, and urinary albumin levels as predictors of mortality and cardiovascular ... patients being independent. None of the patients included in the study had overt evidence of infection on admission on the basis of standard blood and urine tests, X-film...

Ngày tải lên : 08/08/2014, 16:23

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Báo cáo y học: "Coincidence of paroxysmal supraventricular tachycardia and panic disorder: two case reports" pdf

... precipitating and maintaining PD via interoceptive processes or, alternatively, with PD increasing the risk for PSVT by elevating stress levels. As both PSVT and PD require different treatments, potentially ... PSVT and a tachycardic state within a panic attack. During an inva- sive electrophysiological study in July 2000, a rapid typi- cal AV nodal re-entrant tachycardia was diagno...

Ngày tải lên : 08/08/2014, 23:21

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