... α.IL-1Ra increased significantly during the first year in both study groups, but the rise was not sustained until the end of the trial. One hypothesis to explain this finding is that vitaminD3, ... significantly in the HRTgroup. Furthermore, the change in E2 in serum wasinversely, though modestly, correlated with the change in sIL-6R. The change of sIL-6R was inversely associated with increase ... baseline, which haspreviously been observed [35], and, interestingly, the change of ESR during the course of the study was highlycorrelated with the change of IL-6 and to a lesser degreewas inversely...