... rheuma-toid synovial hyperplasia and a clinical benefit of anti-TNF-alpha therapy for RA. Cytokine 2000, 12:28 1-2 88.59. Yamasaki S, Kawakami A, Nakashima T, Nakamura H, Kamachi M,Honda S, Hirai ... may explain why TNF blockadecan induce increases in antinuclear antibodies and at thesame time rapidly reduce inflammation and prevent inflam-mation-induced damage, also observed in SLE patients.These ... alsobeing able to activate anti-apoptotic pathways, and NF-κB in particular, however, TNF can also inhibit apoptosis byinducing a variety of anti-apoptotic molecules, such asinhibitor of apoptosis,...