0
  1. Trang chủ >
  2. Luận Văn - Báo Cáo >
  3. Báo cáo khoa học >

Báo cáo y học: " Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNF-induced MEK/ERK signalling" ppt

Báo cáo y học:

Báo cáo y học: " Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNF-induced MEK/ERK signalling" ppsx

... extracellular matrix and proteinase genes are regulated by TNF-induced MEK/ERK signallingWe further analysed the lists of genes that were induced by TNF using specific gene ontologies. Analysis of the ... activity of NFB and Sox9 in chondrocytes [10,12]. TNF-induced NFB DNA binding in immortalized chondrocytes is reduced by inhibition of MEK1/2 signalling [10]. TNF may thereforeregulate the expression ... significantly cate-gorized by the molecular function of their protein products intocategories that included hyaluronic acid binding activity(including Agc1 and Hapln1) and proteinase activity (includingMmp-9...
  • 14
  • 574
  • 0
Báo cáo y học:

Báo cáo y học: "Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling" ppsx

... effects of diac-erein/rhein on the synthesis of major proteases involved in bone remodelling/resorption, namely MMP-13 and cathepsinK. Moreover, we sought to gain new insight into the effects of the ... μg/mL).Effect of diacerein/rhein on intracellular signalling pathwaysTo gain insight into the mechanisms of these drugs on the OAsubchondral bone osteoblasts, we further studied the effect of the therapeutic ... cathepsin KSince MMP-13 and cathepsin K are produced by the murinecell line Raw 264.7, proteins not recognized by the commer-cially available ELISAs, determinations were performed usingactivity...
  • 10
  • 536
  • 0
Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf

Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf

... regula-tion of HO-2 expression in human cells under hypoxia. In the present study, we have analyzed the effect of hypoxia on the expression levels of HO-1 and HO-2 in various types of human cell line, including ... respect to the intensity for the a-tubulin signal. Shown are the relative expression levels of HO-1 and HO-2 proteins in YN-1 cells (B) and those of HO-2 protein in K562 cells (D). The intensity representing ... responseduring acclimatization to hypoxia.ResultsEffects of hypoxia on HO-1 and HO-2 expression in human cell linesWe initially analyzed the effects of hypoxia on the expression of HO-1 and HO-2 in...
  • 12
  • 621
  • 0
Báo cáo y học:

Báo cáo y học: "Considerations for the inclusion of 2x mammalian genomes in phylogenetic analyses" ppsx

... number of Figure 2. Increase in gene number through evolutionary time for all lineages (blue lines) in the latest Ensembl version (version 59). The red line indicates the lineage leading to the ... duplications at the root of the eutherian mammals increases by only 4.5%. Moreover, the total number of supported duplications is reduced by only 10%. is suggests that the addition of low-coverage ... that the ‘addition of new placental mammal genomes in the gene trees increases the probability of finding a gene misplaced in the tree.’ We had anticipated that possibility in our study (page...
  • 4
  • 338
  • 0
Báo cáo y học:

Báo cáo y học: "Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis" ppt

... luciferin by luciferase in the presence of extremely low levels of ATP. Aftercollecting the chondrocytes by scraping, cells were centri-fuged for 10 min at 500 × g in the cold. Chondrocytes pelletswere ... production in chondrocytes Chondrocyte activity was measured by the production of gly-cosaminoglycan (GAG) from cultured chondrocytes. Chondrocytes were cultured under either normoxic or hypoxicconditions ... radicals) may induce the expression of HIF-1α in articular chondrocytes. IL-1 has beenshown both to inhibit chondrocyte anabolic activity, including the down-regulation of proteoglycan synthesis,...
  • 11
  • 385
  • 0
Báo cáo y học:

Báo cáo y học: "A Comparative Effectiveness Study of Bone Density Changes in Women Over 40 Following Three Bone Health Plans Containing Variations of the Same Novel Plant-sourced Calcium"

... unacceptable by the end of the study. In all three groups and sub-groups, none of the normal scores were abnormal by the end of the study. Thus, it was our conclusion that the absence of changes in the ... supplemen-tation. The increasing number of the elderly is ex-tending the progressive age-related decline in BMD, thereby increasing the need for additional supple-mental calcium and vitamin D3 [5]. There ... re-viewed in the meta-analysis cited above. As for the unusual finding of the increased BMD levels found in the three study groups, the superiority of Plan 3 over Plan 1 suggests that the physical...
  • 12
  • 663
  • 0
Báo cáo y học:

Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"

... subfamily of the cytoch-rome P450 (CYP) enzymatic system, is responsible for the metabolism of tacrolimus [10]. Specifically; tacro-limus is mainly metabolized by CYP3A4 and CYP3A5 enzyme isotype. ... presence of CYP3A5*1 allele does not predict the amount of CYP3A5 protein accurately as it can be affected by other factors, genetic (expression of m-RNA, stability of CYP3A5 protein, dual ... therapy although epigenetic factors must be taken into account [7]. The aim of the present study was to determine the impact of CYP3A5*1 and CYP3A5*3 genotype on the kinetics of tacrolimus in...
  • 7
  • 785
  • 0
Báo cáo y học:

Báo cáo y học: " Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice

... the gastrointestinal tissues from the cytotoxicity of CY in mice. We also profiled the changes of the expression of growth factors in gastric tissues in response to the damage by CY and protection ... Immunology and Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China Corresponding address: Prof. C.H. Cho, Department of Pharmacology, The University of ... protective effect of AP on CY-induced cytotoxicities in both the hemopoietic and gastrointestinal tissues was undefined. Any of these actions would extend the therapeutic application of CY in cancer...
  • 6
  • 655
  • 0
Báo cáo y học:

Báo cáo y học: "Update on the treatment of ocular toxoplasmosis"

... by Rothova et al was 250mg a day or 500mg every other day and therapy was associated with pyrimethamine 100mg on the first day that was fol-lowed by 50mg a day. Prophylaxy of recurrence of ... survey of the opinion of oph-thalmic specialists in uveitis was performed recently by Gary Holland. [3] The reasons that were commonly accepted to introduce a therapy were the following: a) the ... in the therapy of ocular toxoplasmosis. But the out-come was measured 4 weeks after initiation of ther-apy. Dihydrofolate reductase inhibitors (DHFR) have shown their efficacy in vivo in the...
  • 3
  • 522
  • 0

Xem thêm

Từ khóa: báo cáo y họcbáo cáo y học cổ truyềnbáo cáo khoa học y họcbáo cáo y tế học đườngbáo cáo tuần sinh hoạt tập thể đầu năm họcmẫu báo cáo y tế học đườngNghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngBáo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXChuong 2 nhận dạng rui roBT Tieng anh 6 UNIT 2chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ