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Báo cáo y học: "Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis" pdf

Báo cáo y học:

Báo cáo y học: "Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis" pdf

... response.Identifying the signalling pathways that are involved in inducing the observed alterations in MMP expression maycontribute to our understanding of the initiation of kidneydamage in lupus nephritis. ... Candidatemediators of such changes include enzymes and signallingsubstances involved in maintaining the delicate balancebetween synthesis and breakdown of the proteins and proteoglycans that make up the ECM.Although ... understanding of MMP/tissue inhibitor of metalloproteinase function within the kidney, and discuss their possible involvement in the development and progression of lupus nephritis.IntroductionSystemic...
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Báo cáo y học: "between a chicken and a grape: estimating the number of human genes." pdf

... the even greater uncertainty surrounding their numbers. In recent years, as a result of the dramatic breakthroughs in our understanding of RNA interference [7] and miRNAs [8], the number and ... by locating a highly similar protein-coding sequence in another organism. Together with EST and cDNA alignments, gene finding by homology is the first step in all the major annotation pipelines. ... precisely known. Interestingly, a recent study provides the first evidence for the de novo origin of human protein-coding genes, which evolved from non-coding DNA after the divergence of humans and...
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Báo cáo y học: Esterified Hyaluronic Acid and Autologous Bone in the Surgical Correction of the Infra-Bone Defects

Báo cáo y học: Esterified Hyaluronic Acid and Autologous Bone in the Surgical Correction of the Infra-Bone Defects"

... probing was recorded and the presence of plaque was registred mesially, buccally, distally, and lingually. Data were obtained at baseline before treatment and at 10 days, and 6,9, and 24 months after ... characteristic is largely responsible for the consistency of the active component that can act as a barrier to the spread of any bacteria penetrating the tissues including those of the periodontium. ... number of medical disciplines, as evi-dent in ophthalmology, dermatology, dentistry and rheumatology [10,11]. Based up on these data the aim of this study was to observe the potential of Esterified...
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Báo cáo y học: "Enhanced glutamate, IP3 and cAMP activity in the cerebral cortex of Unilateral 6-hydroxydopamine induced Parkinson’s rats: Effect of 5-HT, GABA and bone marrow cell supplementation" ppsx

... bound/freeon the Y- axis. The maximal binding is a measure of the total number of r eceptors present in the tissue and the equilibrium dissociation constant is the measure of the affinity of the receptors ... MK-801 binding was obtained by subtractingnonspecific binding in the presence of 100 μM unlabeledMK-801 from the total binding.Protein DeterminationProtein was measured [24] using bovine serum ... todopamine depletion in the striatum and indirectly to cortical dysfunction. Increased glutamatergic transmission in the basal ganglia is implicated in the pathophysiology of Parkinson’s disease and...
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Báo cáo khoa học: Functionally distinct dopamine and octopamine transporters in the CNS of the cabbage looper moth* potx

Báo cáo khoa học: Functionally distinct dopamine and octopamine transporters in the CNS of the cabbage looper moth* potx

... the moth OAT substitute for DAT in dopami-nergic signaling pathways in the moth CNS, and what is the nature of the mechanism that substitutes for OAT in the octopaminergic pathways in the y ... phenolamineoctopamine (OA) and the indolamine serotonin (5-HT) in uence a variety of behaviors in invertebrates through their actions as neurotransmitters, neurohormones and/ orneuromodulators [1,2]. In insects, ... toolfactory stimuli in honeybees [6].Following their release, biogenic amines are selectivelyretrieved at the neural synapse by a family of Na+/Cl–-dependent transport proteins. These proteins...
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Báo cáo y học: "Potassium Deposition During And After Hypokinesia In Potassium Supplemented And Unsupplemented Rats"

... diminished size of electrolyte pool of cell, 3) change in electrolyte content of cell and 3) injury of skeletal muscle cell that change integrity of sarcolemma and results in release of intracellular ... cleaned daily in the morning before feeding. The studies were approved by the Committee for the Protection of Animals. Assignment of animals into four groups was performed randomly and their conditions ... SD, Afonin VB and Kakurin VJ. Potassium measurements during hypokinesia and ambulation in establishing potassium changes in trained and untrained subjects. Sports Medicine Training and Rehabilitation,...
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Báo cáo y học: " MRI bone oedema scores are higher in the arthritis mutilans form of psoriatic arthritis and correlate with high radiographic scores for joint damage" ppt

... clinical and MRI findings.Clinical definition of arthritis mutilansClinical digitised photographs of the hands and feet wereobtained in 25 of the 28 patients. These were examined by arheumatologist ... pertain only to baseline findings in thesepatients, before administration of the study drug or placebo.All patients gave informed consent according to the require-ments of the New Zealand Multiregion ... imaging of the wrist; the patientwas repositioned so that the fingers were within the coil; and then enhanced imaging of the fingers was performed. Boneoedema was investigated using short tau inversion...
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Báo cáo y học: "Neural immune pathways and their connection to inflammatory diseases" ppsx

... whether these alter-ations in neuroendocrine pathways and receptors areinvolved in the pathogenesis of RA or whether they are aresult of the inflammatory status of the disease.New therapiesOn the ... modulat-ing the immune and neuroendrocrine systems. Cytokines and their receptors are expressed in the neuroendocrinesystem and exert their effects both centrally and peripher-ally [100–102].Systemic ... Finally,animal models have shown defects in the sympathetic and parasympathetic nervous system in arthritis. These findingshave led to the development and testing of novel therapies(see the...
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Báo cáo y học: "Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development" docx

... to asoftening of definitions. Equipoise, it has been suggested,could represent uncertainty in the collective conventionalscientific wisdom, in the patient community, or in the mind of the potential ... is of greater value to the participant than declining the RCT and accepting usualcare, and the study is ethically sound – but it does notmeet the weaker principle of ‘equipoise’ or ‘uncertainty’.Placebo-controlled ... versus the expected benefits and risks of the trial after pooling all arms, and that the decision point always comes before randomization and hence is independent of the relativeexpectations for the...
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