... matrix proteins,including vitronectin, osteopontin, and bone sialoprotein. Arg-Gly-Asp-containing peptides, Arg-Gly-Asp mimetics, and blocking antibodies to αvβ3integrins inhibit bone resorption in ... measured by X-ray analysis.The RA joint synovial fluid and synovium contain a variety of hematopoeitic cells that are in direct proximity with thearticular cartilage and underlying bone, and that ... independently of theRANK/RANKL signaling pathway, via TNF and IL-1α signaling [46]. Stimulatory, costimulatory, and/ or inhibitorysignals may be provided by adjacent T cells present in theinflammatory...