Báo cáo y học: "Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on" pps
Báo cáo y học: "Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on" pps
... Changes in the methylation status of ReviewTargeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on?Aleksander ... of HAT activity to HDAC activity may sensitize cells to inflammatory gene transcription via chromatin remodeling,may increase the DNA binding and activity of transcriptionfactors, and may increase ... Recent findings in the study of inflammatory lung diseases demonstrate that HAT activity and HDAC activity significantly impact upon the clinical efficacy of GCtherapy [15]. GC receptor-binding...
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Báo cáo y học: "Randomized controlled trial design in rheumatoid arthritis: the past decade" docx
... parenteraladministration, including rapid onset of effect, infusion, and injection site reactions, which may result in expectation bias as well as unblinding. Most importantly, placebo has beennecessary to prove inefficacy ... Trial in Rheumatoid Arthritis with Concomitant Therapy; COX-2 = cyclooxygenase-2; DAS = Disease Activity Score;DMARD = disease-modifying antirheumatic drug; ERA = Etanercept in Early Rheumatoid Arthritis; ... Active Controlled Study of Patients Receiving Infliximab for Treatment of Rheumatoid Arthritis of Early Onset; ASSURE = Abatacept Study of Safety in Use with Other Rheumatoid Arthritis Therapies;...
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Báo cáo y học: "Apolipoprotein A-I infiltration in rheumatoid arthritis synovial tissue: a control mechanism of cytokine production" pot
... newlyemerging, include anti -inflammatory activities and therefore haveimportant implications for the treatment of chronic inflammatory diseases.Keywords: apolipoprotein A-I, cytokines, inflammation, ... levels may inversely correlatewith disease activity. The observation that apoA-I can infil-trate and be retained at the inflammatory site suggests thatapoA-I may inhibit the local triggering of ... Reilly K, Swindell AC, Buss JM, AndersonNL: Analysis of changes in acute-phase plasma proteins in anacute inflammatory response and in rheumatoid arthritis usingtwo-dimensional gel electrophoresis....
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Báo cáo y học: "CD147 overexpression on synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes" pptx
... characterized by chronic prolifer-ative synovitis, with hyperplasia of the synovial lining cells, inflammatory cell infiltration and angiogenesis in the subliningcell layer. Hyperplastic synovial lining ... and bone, destroy-ing the joint. MMPs, mainly produced in FLS, play a central role in arthritic joint destruction. Beyond the proof that the expres-sions of MMP-2 and MMP-9 as well as the invasive ... 2Gelatin zymography of culture medium conditioned by fibroblast-like synoviocytes (FLS) and THP-1 cellsGelatin zymography of culture medium conditioned by fibroblast-like synoviocytes (FLS) and...
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Báo cáo y học: "NGR1 single nucleotide polymorphisms in rheumatoid arthritis" pdf
... frequencies of SNPs linked toRA have been already reported [8]. Analysis of RA-associatedSNPs in solute carrier family 22 members 4 and 5 (SLC22A4 and SLC22A5) [9] and in protein tyrosine phosphatase(PTPN22) ... primer).Results and discussion In marked contrast to previous findings, no polymorphic alleles(neither thymine at position 40 nor cytosine at position 1,400)were detected in any of the individuals ... (4.4%) in a small cohort of 91 healthy controls and even in 15 out of 96(15.6%) lupus patients [7], and heterozygosity at position1,400 (L467P) was detected in four individuals (6.7%) in acohort...
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Báo cáo y học: "Remission by composite scores in rheumatoid arthritis: are ankles and feet important" pptx
... evalua-tion of joint activity, therefore, is a prerequisite of disease activ-ity assessment in RA. In this study, we showed that theassessment of joint activity in the feet, beyond assessment of joint ... measures of disease activity In an exploratory analysis, we employed the 32-joint counts tocalculate disease activity indices using the DAS28 and SDAIformulae and defined remission by the traditional ... ankles and feet.The aim of the present study was to determine the relevance of excluding joints of the ankles and feet in the assessment of RAdisease activity and remission. Using a longitudinalobservational...
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Báo cáo y học: "The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now" potx
... recognition that clinicalassessment (measuring and noting the change in index and the disease activity state attained) early in the course of therapy (3 to 6 months after initiation of therapy) allows ... of the type of therapyor disease duration, however, 3 months after initiation of treatment the disease activity – as assessed by the SimplifiedDisease Activity Index, the Clinical Disease Activity ... Disease Activity Index and the Clinical Disease Activity Index (reviewed in [9]) – have been shown useful forfollowing disease activity and for serving as endpoints in clinical trials and observational...
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Báo cáo y học: "Lower paraoxonase 1 activity in Tunisian bipolar I patients" pptx
... was no significant change in paraoxonase activity in relation to illness episodes, whereas the lowest values of this activity were seen in manic patients. In contrast,paraoxonase activity was ... purpose of this study was to investigate the variations of paraoxonase activity and lipid profile in bipolar I patients, and the association of this activity with the sociodemographic, clinical and ... directly associated with increasedmorbidity and mortality [1]. The exact mechanismsincreasing the incidence of cardiovascular risk in bipolarpatients remain to be clarified, but t hey possibly includeindustrialisation,...
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Báo cáo Y học: Potential active-site residues in polyneuridine aldehyde esterase, a central enzyme of indole alkaloid biosynthesis, by modelling and site-directed mutagenesis ppt
... standardenzyme assay, the kinetic studies (Km, kcat) were completedfor the active muteins and for the wild-type enzyme.Enzyme and protein assaysProtein concentrations of the muteins and ... enzyme of ajmaline biosynthesis, as a new member, into the a/b hydrolase enzyme super-family. Most typical for this class of hydrolases are the threestrictly conserved amino acids Ser, Asp, and ... biosynthetic sequence are cata-lyzed by membrane-bound and soluble enzymes such as cytochrome P450-dependent hydroxylases, a synthase, sev-eral reductases, a methyltransferase and a set of hydrolasesincluding...
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Báo cáo y học: "ncreased serum HO-1 in hemophagocytic syndrome and adult-onset Still''''s disease: use in the differential diagnosis of hyperferritinemia" docx
... the study. YK, MT, and MI, con-ducted the laboratory work. YK, MT, AU, SO, AS, HK, KT, and YI were involved in the analysis and interpretation of data. YK,MT, and YI were involved in writing the ... heme oxygenase (HO)-1 and ferritin in hemophagocytic syndrome (HPS) and adult-onset Still's disease (ASD)Serum heme oxygenase (HO)-1 and ferritin in hemophagocytic syndrome (HPS) and adult-onset ... be useful in the differential diagnosis of hyperferritinemia and perhaps also in monitoring disease activity in HPS and ASD.IntroductionHeme oxygenase (HO) is an enzyme that catalyzes the conver-sion...
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Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngchuyên đề điện xoay chiều theo dạngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longPhát hiện xâm nhập dựa trên thuật toán k meansChuong 2 nhận dạng rui roGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM