... characterization of species of fibronectin bearingsequences from the N-terminal heparin-binding domain in synovial fluid samples from patients with osteoarthritis and rheumatoid arthritis John ... Minneola, NY,USA. Fluid was drawn into plastic syringes and placeddirectly into tubes containing EDTA, phenylmethylsulfonylfluoride (PMSF), and aprotinin at final concentrations5.7 mM, 1 mM, and ... the N-terminal heparin-binding domain,the gelatin-binding domain, the central CBD, and the EIIIAsegment. The ~170-kDa N-terminal species of FN maytherefore be both a participant in joint destructive...