... supports the hypothesis that the hypersensitivity reaction to NVP may be HLA-associated[9,12,13], while HLA-alleles have also been identified asclinically relevant susceptibility markers for hypersensitiv-ity ... fre-quency of HLA-B*14 is nearly 0% in Japan. On the otherhand, the frequency of HLA-Cw*08-positive patients in the NVP hypersensitive group was 42%, which was signif-icantly higher than that the ... conceived of the study, participated in the design andcoordination of the study, and drafted the manuscript, TRcarried out genotyping and analysis of clinical data, SF car-ried out genotyping...