Báo cáo y học: "Serum keratan sulfate transiently increases in the early stage of osteoarthritis during strenuous running of rats: protective effect of intraarticular hyaluronan injection" docx
Báo cáo y học: "Serum keratan sulfate transiently increases in the early stage of osteoarthritis during strenuous running of rats: protective effect of intraarticular hyaluronan injection" docx
... 1Research articleSerum keratan sulfate transiently increases in the early stage of osteoarthritis during strenuous running of rats: protective effect of intraarticular hyaluronan injectionTao Tang1, ... not induce the repair of osteochondral defect. Interestingly, remarkablystrong staining for hyaluronan was demonstrated in areas thatwere simultaneously devoid of staining for keratan sulfate ... kera-tan sulfate increased sharply 1 day after injection of chymopa-pain into the knee joint in rabbits [26]. The serum keratan sulfate also sharply decreased, and these changes wereaccompanied by...
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Báo cáo y học: " Serum Interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study" pps
... a therapeutic target in AKI. Modulation of these cytokines may reduce the degree of kidney injury itself,as well as the deleterious effects of kidney injury on other endorgans, including the ... University of Cincinnati School of Medicine, Cincinnati, OH, USA4Section of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, ... is the surgery and bypass itself. Thus, the tim-ing of the insult is clear. Based on our animal studies, wehypothesized that levels of proinflammatory cytokines wouldincrease early after the...
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Tài liệu Báo cáo Y học: Soluble silk-like organic matrix in the nacreous layer of the bivalve Pinctada maxima A new insight in the biomineralization field pptx
... alanine (6.5%). Thus, the alanine and glycinecontent of WSM was rather similar to that of EDTA-IM. In spite of the presence of mineral, it was possible to analyze the amino acid composition of the ... being quite glutamic acid-rich in WSM.Glycosaminoglycan analysisGlycosaminoglycans are highly negatively charged because of the presence of sulfate ester and/or carboxyl groups.Therefore, they ... revealed the predominance of two amino acids: alanine (39.2%) andglycine (30%). Interestingly, the proportions are very similarto those found in WSM for alanine and glycine.Curiously, the presence...
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Báo cáo Y học: Probing intermolecular protein–protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET) potx
... alternate interpretation of the lack of agonist-inducedBRET observed in this study is that the translation of agonist binding to the ATDs of the family C GPCRhomodimer into G-protein coupling of the ... 2002Agonist-induced rearrangement of the 7TMs in the CaR homodimer?One of the goals of the present study was to investigate,whether the activating twist in the ATD dimer of the familyC GPCR homodimer ... the ATDs of the CaR homodimer. Further investigations into the signal transference from the ATDs to the G-proteincoupling areas of the receptor homodimer are clearlyneeded in order to gain a better...
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Báo cáo y học: " Chemokine blockade: a new era in the treatment of rheumatoid arthritis" ppsx
... scatteredthroughout the rheumatoid synovium, and most of the CCR1-positive cells are macrophages, which play a keyrole in synovial inflammation. The rationale for the clinicalstudy was supported by interesting ... on the available in vivo data, whichmay provide more insight into the chances that disruptingone single factor of the complicated chemokine networkcould be clinically effective in chronic inflammatorydisorders ... of a variety of inflammatory chemokines and their receptors [5,6]. In vitrostudies have suggested that both so-called homeostaticchemokines and inflammatory chemokines, including CCchemokine...
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Báo cáo y học: "Cold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertension" ppt
... processesunderlying RP and PAH contribute to the familiar pattern of skin, renal and gastrointestinal pathology. The emergence of effective and conveniently administered therapy for PAH increases the importance ... vasculopathy of SScl mayalso be modifiable. In the characteristic microangiopathy of SScl, luminalnarrowing results from a combination of intimal proliferation,medial hypertrophy and adventitial ... cell dysfunction is characterised bydecreased production of the vasodilators nitric oxide andprostacyclin, and by enhanced release of endothelin-1.Endothelial cell dysfunction influences the...
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Báo cáo y học: "Interleukin-15 and interferon-γ participate in the cross-talk between natural killer and monocytic cells required for tumour necrosis factor production" docx
... supporting the importance of intercellular contacts in the pathogenicmechanisms underlying RA. Indeed, the importance of thesecell-cell interactions in the synthesis and release of pro-inflam-matory ... currently the most importantcytokine in the pathogenesis of RA, the mechanisms involved in the perpetuation of TNF production in the rheumatoid syn-ovium are not yet fully understood [1,8]. In this ... stimu-late monocytic cells, resulting in the synthesis of TNF. Thisfinding opens the possibility of exploring new therapeutic tar-gets for RA and probably other chronic inflammatory disor-Arthritis...
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Báo cáo y học: "MLN51 and GM-CSF involvement in the proliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis" pps
... important in the proliferation of RA FLSs in the pathogenesis of RA.IntroductionSynovial tissue from healthy individuals consists of a singlelayer of synovial cells without infiltration of inflammatory ... purposes)Figure 5Inhibitory effects of neutralizing antibodies to cytokines on the SF-mediated proliferation capacity of RA FLSsInhibitory effects of neutralizing antibodies to cytokines on the SF-mediated ... next investigated whether SFs have an effect on the growth rate of RA FLSs, what kinds of factors in the SFs areinvolved in the proliferation of RA FLSs, and whether the fac-tors have a role in...
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Báo cáo y học: "Falling into TRAPS – receptor misfolding in the TNF receptor 1-associated periodic fever syndrome" ppsx
... neutrophil-specificprotein Pyrin [2]. Most evidence currently suggests that pyrinnegatively regulates the production of IL-1β – a majorproinflammatory cytokine of the innate immune response ... intracellulardomain of TNFR1. A definitive list of all the TRAPS mutationscan be found on the INFEVERS website [43]. Many of the mutations involve cysteine residues involved in intramoleculardisulphide ... Gadina M, Karenko L, Petters-son T, et al.: Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of domi-nantly inherited autoinflammatory syndromes....
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Báo cáo y học: "Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity" pdf
... type II synthesis, whereas proteoglycan synthesis wasstrongly attenuated. In contrast, at the time of maximal aggre-canase activity, the proteoglycan loss was fully reversible.These findings ... points. Proteoglycans in the cartilage were visualized using Alcian blue staining, the same dye used in the S-GAG assay. The control articular car-tilage explants (shown in the bottom row of ... repair capacity. The current study has some important limitations, whichinclude the use of young bovine cartilage and the use of the synchronous cultures. The synchronous induction of cartilagedegradation...
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