Báo cáo y học: "The role of tumor necrosis factor-alpha in systemic lupus erythematosus" pdf
Báo cáo y học: "The role of tumor necrosis factor-alpha in systemic lupus erythematosus" pdf
... severe lupus. ReviewThe role of tumor necrosis factor-alpha in systemic lupus erythematosusMartin Aringer1and Josef S Smolen21Division of Rheumatology, Department of Medicine III, University ... tointerfere with the inflammatory response in SLE by adminis-tering only an induction regime of four infusions of infliximabwithin 10 weeks rather than by planning for long-term therapy.Evidence ... permeability.J Clin Invest 2002, 110:433-435.67. Aringer M, Graninger WB, Steiner G, Smolen JS: Safety and effi-cacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus:...
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Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc
... higher in CD25-depleted mice. (b) Haematoxylin and eosin stained frontal knee joint sections were scored on a 0–3 point scale at day 14 of AIA for each of the following: severity of synovial hyperplasia, ... and/or draining lymph nodes, forinstance in tolerated allografts [28], in Langerhans isletsand pancreatic lymph nodes in inflammation-induced dia-betes [29], in chronically inflamed skin in a Leishmaniainfection ... Germany) intraperitoneally.Arthritis was induced by intra-articular injection of 100 µgmBSA in 25 µl phosphate-buffered saline (PBS) into theright knee joint cavity.Arthritis severity was...
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Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf
... glycosylated proteins of about 50–90 kDa.The single polypeptide chain of a kininogen contains threedomains resembling family 2 cystatins.Cystatins competitively inhibit the activity of papain-like ... second binding loops of cystatin B andfamily 2 cystatins and also what residues of this loop in cystatin A may participate in the interaction.To elucidate the role of the second binding loop of ... energy to the interaction of cystatin B with cysteine proteases [37]. The sequence of thesecond binding loop of the related family 1 cystatin,cystatin A, differs appreciably from that of cystatin...
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Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... Tyr. These mutations may in uence the shape and volume of the acyl binding pocketand thereby alter the binding mode and affinity of theenzyme for PAA and derivatives thereof, while maintainingthe ... phenylglycyl- and p-hydroxyphe-nylglycyl-enzyme of bF24A, as indicated by, respectively, atwofold and fourfold increased Vs/Vhratiocomparedtothewild-type (Table 4). The Vs/Vhratio using ... penicillin acylase; PAA, phenylacetic acid; PAAM,phenylacetamide; PAAOM, phenylacetic acid methyl ester; PG, phe-nylglycine; (H)PGA, (p-hydroxy)-D-phenylglycine amide; (H)PGM,(p-hydroxy)-D-phenylglycine...
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Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc
... &Penner-Hahn, J.E. (1998) Characterization of the zinc binding site in methionine synthase enzymes of Escherichia coli – the role of zinc in the methylation of homocysteine. J. Am. Chem Soc. 120,8410–8416.15. ... toligation of the thiol group of coenzyme M. Mutations in His237 or Cys239, which are proposed to be involved in ligating zinc, resulted in an over 90% loss in enzyme activityand in distinct changes in ... isa zinc protein that catalyzes the methylation of coenzyme M(HS-CoM) with methylcob(III)alamin. We report zincXAFS (X-ray absorption fine structure) results indicatingthat, in the absence of...
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Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx
... carboxyl group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparentlyplaying a less important role in side-chain binding. Takentogether, the results of this ... ternary com-plex to oxygen binding, thereby initiating catalysis andensuring coupling of 2-oxoglutarate conversion to primesubstrate oxidation. In the case of DAOCS it has been previously shown ... Pharmacy and Pharmacology, The University of Bath, UKDeacetoxycephalosporin C synthase (DAOCS) catalyses theoxidative ring expansion of penicillin N, the committed step in the biosynthesis of cephamycin...
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Báo cáo y học: "The role of Probiotics in allergic diseases" pptx
... allergy.factors influencing development of the microbiota. Ann Med1999, 31(4):288-92.15. Kalliomaki M, Isolauri E: Role of intestinal flora in the develop-ment of allergy. Curr Opin Allergy Clin ... The role of the intestinalmicroflora for the development of the immune system in early childhood. Eur J Nutr 2002, 41(Suppi 1):I32-7.18. Penders J, et al.: Molecular finger printing of the intestinalmicrobiota ... delivery. The frequency of developingatopic dermatitis in the offspring was significantlyreduced by 2, 4, and 7 years [26-28], by 50%, 44%, and36% respectively.Similar studies have yielded...
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Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc
... activity of a glucocorticoid-regulated inflammatorycyclooxygenase. Proc Natl Acad Sci USA 1992, 89:4888-4892.7. Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflam-matory therapy. ... their role in bone metabolism and repairremains unclear.Review of the evidenceTo determine the role of COX-2 in bone repair, investiga-tors have studied fracture healing in animal models of COX-2 ... their pain for only afew days or weeks, it is unclear whether short-term inhibi-tion of COX-2 is really significant to the quality or timeli-ness of the healing. Indeed, the study by Zhang...
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Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt
... occurs at theβ-carbon of the asparagine residue, consequently (by way of steric hindrance) preventing the interaction of the HIF-αC-TAD with the cysteine/histidine-rich 1 domain of p300, aco-activator ... variation in therelative expression of the PHD isoforms in different cells, withPHD-2 being the most abundant HIF prolyl hydroxylase.Specific ‘silencing’ of all three enzymes using short interferingRNA ... player in stabilizingHIF in normoxia in most, but not all, cell lines. Although PHDenzymes regulate stability of HIF and thereby induce cellularadaptations in response to hypoxia, it remains...
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Báo cáo y học: "The role of osteoprotegerin in arthritis" ppsx
... consequently lead to increasing inter-est in the role of osteoclasts in local bone erosion that isdriven by the hypothesis that synovial pannus makes useReviewThe role of osteoprotegerin in arthritisGeorg ... Collagen-induced arthritisSpecies Rat Mouse RatDose 1 mg/kg/day 6.4 mg/kg/day 3 mg/kg/dayStart Onset of symptoms Onset of symptoms Onset of symptomsDuration 7 days 35 days 5 daysEffect on inflammation ... page of themanuscript published by Anton Weichselbaum in the Archives forPathology, Anatomy, Physiology and Clinical Medicine in 1878. (c)Title of the manuscript, meaning “The finer changes of...
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