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Báo cáo y học: "A critical appraisal of guidelines for the management of knee osteoarthritis using Appraisal of Guidelines Research and Evaluation criteria" doc

Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx

Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx

... otypic analysis (at the p rotein level), the f ewanimals yielding in their milk the as1-CasM variant wereexclusively heterozygous M/F a t the as1-Cas locus. There-fore, analysis o f their ... variant, given the intensity of the isoelectrofocusing bands and the surface of the relevant peak in RP-HPLC.Fig. 6. Nucleotide sequence of the expected as1-CasM cDNA obtained by genomic e xon ... (fully), and Ser41 and Ser115 (partly), which originate in proteins withfive, six and seven phosphates/mol, explaining the hetero-geneity of phosphorylation observed for the n ative proteinby...
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Báo cáo y học: " A 1-year case-control study in patients with rheumatoid arthritis indicates prevention of loss of bone mineral density in both responders and nonresponders to infliximab" docx

... antero-posteriorview) and at the right femoral neck, by dual-energy X rayabsorptiometry using a QDR 4500 device (Hologic, Waltham,MA, USA). Quality control for the device was performed bydaily assessment of ... Concomitant Therapy] protocol [7]). All of these patients were included in the study and followed over 1year.RA activity was evaluated using the Disease Activity Score(DAS)28 [12], and a good ... participate inthis study, which was approved by the ethics committee. Thisstudy was performed by the investigators, independent of and unsupported by Centocor or Schering-Plough. The control group...
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Báo cáo y học: " A scalable, fully automated process for construction of sequence-ready barcoded libraries for 454" pps

... which the optical plate can sit and be defined on the deck of anyautomation.Settings used for plate-based shearing of DNA are:Duty Cycle of 5; Intensity of 5; Cycle per Burst of 500;Seconds of ... sequences are added to the end of the 454 A adapter via DNA synthesis (Integrated DNA Tech-nology). The lengths of each portion of the adapter and the approximate length of the insert are indicated. ... in the low input and multiplexed library construc-tion study design, CN guided and directed the application of the processimprovements, and RN directed the design and implementation of the...
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Báo cáo y học: "A scalable, fully automated process for construction of sequence-ready human exome targeted capture libraries" pot

... development of critical quality control assays, both in terms of theirsensitivity to the samples at the point at which they areassayed, as well as their utility as a predictor of sequen-cing quality. ... 4329001).Robot performance quality control by dye handlingPrecision performance of the liquid handling robot ismaintained by regular quality control. A dummy run isperformed daily in which 5 μl of a 0.1-M ... quality control of automation The Bravo automated liquid handling platform is assayeddaily for dispense accuracy and precision using a quantita-tive fluorescent dye assay (Figure 4d). Standard...
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Báo cáo y học: "A case-series study to explore the efficacy of foot orthoses in treating first metatarsophalangeal joint pain" pot

... agreementwith other authors who have explored the efficacy of variously produced foot o rthoses for other indications[45,46]. Contrary to the hypothesised mode of action[16], the exploratory analysis ... Microsoft Excel™ and SPSS version 15 for Windows. The analysis strategy wasdivided into two phases, an efficacy phase and anexplorato ry phase. For the efficacy analysis, comparisons of pain ... at the 24 week endpoint.Gait AnalysisAt the 8 wee k review, 1 0 participants were invited toparticipate in the 2ndstage of the study exploring the Figure 1 Type of foot ort hoses used in the...
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Tài liệu Báo cáo Y học: Interallelic complementation provides genetic evidence for the multimeric organization of the Phycomyces blakesleeanus phytoene dehydrogenase doc

Tài liệu Báo cáo Y học: Interallelic complementation provides genetic evidence for the multimeric organization of the Phycomyces blakesleeanus phytoene dehydrogenase doc

... 2002understanding of the function and organization of the enzyme complex, the analysis of mutant a lleles of the ge nesinvolved in the biosynthetic pathway c an certainly providevaluable information.In ... been described for bothZygomycetes. In Phycomyces they complement neither the carR nor the carA mutants, and i n Mucor they complementneither the carP nor the carR mutants. They are white, l ... carotenoid pathway to b-carot eneproceeds via three enzymatic steps carried out by the enzymes phytoene synthase, phytoene dehydrogenase and lycopene cyclase. The enzyme phytoene dehydrogenase isable...
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Báo cáo y học: "Cold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertension" ppt

... at1 year and 2 years of 96% and 89% compared withViewpointCold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertensionFrances C HallUniversity of ... processesunderlying RP and PAH contribute to the familiar pattern of skin, renal and gastrointestinal pathology. The emergence of effective and conveniently administered therapy for PAHincreases the importance ... cell dysfunction is characterised bydecreased production of the vasodilators nitric oxide and prostacyclin, and by enhanced release of endothelin-1.Endothelial cell dysfunction influences the...
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Báo cáo y học: "A cell-cycle independent role for p21 in regulating synovial fibroblast migration in rheumatoid arthritis" pps

... occurring in the presence of MMC, we deter-mined the number of WT and p21(-/-) FLS in the presence and absence of MMC at the end of the assay and compared it with the number of cells plated at the ... phases of the cell cycle is dependent on the activities of cyclin dependent kinases (cdks) bound to theircognate cyclins [1,2]. Another level of cell cycle regulation isaffected by the cdk ... randomly designated #1 to #4. For this assay, the PBS counts used for normalization pur-poses were 6 for the WT FLS and 10 for the p21(-/-) FLS. The Figure 1p21(-/-) fibroblast-like synoviocytes...
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Báo cáo y học: "Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis" pdf

... prevented by the overexpression of Bcl-2/Bcl-xL or by the complete ablation of Bax and Bak [22]. The induction of apoptosis mediated by the extrinsic pathwayis initiated by binding of death ligands ... macrophages.Figure 4Loss of Bid does not alter the cytokine and chemokine milieu of the jointLoss of Bid does not alter the cytokine and chemokine milieu of the joint. (a) Pro-inflammatory cytokine production ... purposes)invasion of leukocytes, proliferation of synoviocytes resulting in the thickening of the synovial lining, formation of pannus, and erosion of cartilage and bone [40]. The K/BxN serum transfermodel...
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Báo cáo y học: "Adherence with urate-lowering therapies for the treatment of gout" pps

... is solely the responsibility of the authors and does not necessarily rep-resent the official views of the National Institute of Arthritis and Muscu-loskeletal and Skin Diseases or the National ... interpretation of the data, and critiquing of drafts of this article. BB wasinvolved in the design of this project, analysis and interpreta-tion of the data, and critiquing of drafts of this article. ... interpretation of the data and cri-tiquing of drafts of this article. HF was involved in the analysis of data from this study and interpretation and presentation of results. RY was involved in the interpretation...
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