... levels. Such additionalamino acid r esidues are also fou nd in t he DNases I of amphibians [19]. As in a mphibian DNases I, the insertio n of an additional amino acid residue into the shark enzymesmay ... as the Mammalia tomaintain higher DNase I activity l evels in vivo.Alackof,ordecrease in, DNase I activity has been suggested to be acritical factor in the initiation of human and rat SLE [5,6].AcknowledgementsThis ... (frog), avian (hen), reptilian (snake) and Osteichthyes ( carp) enzymes we re tested for cross-inhibition of activity, all five antibodies were ineffectiveagainst the shark DNase I, indicating that,...