Báo cáo khoa học: " Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation" pps

... 9(page number not for citation purposes)Radiation OncologyOpen AccessResearch Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiationJeffrey ... within the contexts of these models [11]. In this report we describe a kinetic model of tumor trans-port in the craniospinal axis (subarachnoid space and ventricle spaces) for medulloblastoma. The ... chemotherapy and radia-tion to the entire craniospinal axis (brain and spine), alsoknown as craniospinal irradiation (CSI) [2]. Radiothera-pists treat the entire craniospinal axis because the tumor cells...

Báo cáo khoa học: "Immunohistochemical study of caveolin-1 and -2 in the rat retina" pps

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Báo cáo khoa học: "Qualitative Modeling of Spatial Prepositions and Motion Expressions" docx

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Báo cáo khoa học: Different roles of two c-tubulin isotypes in the cytoskeleton of the Antarctic ciliate Euplotes focardii Remodelling of interaction surfaces may enhance microtubule nucleation at low temperature doc

... also candidates for adaptive compensation. Amino acid changesadjacent to the T3 loop and within the T5 loop may in uence the binding afﬁnity and hydrolysis of GTP and ⁄ or the egress of GDP and ... participates in the assembly of the mitotic spindle of E. focardii and that both isotypes are involved in the nucleation of other microtubule structures.Finally, we examined the distribution of E. ... similarsubstitution of alanine for arginine 72 in the c-tubu-lins of T. thermophila and A. nidulans yields a lethalphenotype [25,26]. Together, these results implicateposition 72 as being important for thermal...

Báo cáo khoa học: Structural characterization of a novel branching pattern in the lipopolysaccharide from nontypeable Haemophilus inﬂuenzae pot

... HepHepb|Hex2-Hex-Hep-AnKdo-ol|Hep|HepaMajor isomer of the Hex3 glycoform (estimated from the intensity of the fragments in MS2experiments).bMinor isomer of the Hex3 glycoform (estimated from the intensity of the fragments in MS2experiments).Fig. ... were observed. From the combineddata, the structure in Fig. 8 is proposed for the Hex5glycoform in the Hep4-glycoform population of NTHistrain 981. The Hex3 and Hex1 glycoforms are probablysequential ... The structures of the other Hep3-glycoforms were obtained in ananalogous manner (data not shown) and for all glycoforms the hexoses were found to be members of a linear chainattached to HepI (Table 3).For...

Báo cáo khoa học: Identiﬁcation of two cysteine residues involved in the binding of UDP-GalNAc to UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) ppt

... possiblylocated at the catalytic site of GalNAc-T1, might beinvolved in the catalytic function of the enzyme.To investigate whether the cysteine residues modiﬁed byPCMPS are involved in the binding of UDP-GalNAc,we ... tail and the transmembrane region weredeleted from the rat isozyme, and an insulin signal sequence and a Protein A-IgG binding domain were fused to the resulting N terminus of the sequence. The ... amajor site of interaction with UDP-GalNAc, Cys214 is alsoinvolved in binding.PCMPS and DFP modiﬁcation of the serine-mutants of GalNAc-T1We also examined the sensitivity of the three serine mutantsto...

Báo cáo khoa học: Membrane distribution of epidermal growth factor receptors in cells expressing different gangliosides doc

... microdomains (GEM) of the plasma membrane and to be involved in the regulation of epidermal growth factor receptor (EGFr or ErbB1) activity. To gain furtherinsight into the mechanisms involved in ... the glycolipid composition of the plasma membrane by altering the gangliosidebiosynthetic activity of the cell, while maintaining the normal process of intracellular transport and membraneinsertion ... Igrecognizing the extracellular domain. In addition, to ease the separation between GEM and other parts of the plasmamembrane, the focal plane was mainly adjusted through the top of the cell, allowing...

Báo cáo khoa học: Differential binding of human immunoagents and Herceptin to the ErbB2 receptor ppt

... a single set of identical independent bind-ing sites, using the Bindwork software supplied with the instrument, which provided the stoichiometry of binding (nligand : protein), the change in ... function of the molar ratio, indicate a binding stoichiometry of 1 : 1 for ERB-hRNase and Erbicin and of 0.5 : 1 for ERB-hcAb and Herceptin, i.e. each identical antigenbinding site binds one ... immunoagents in NaCl ⁄ Pisolu-tion were injected into the ErbB2-ECD solution in NaCl ⁄ Piat 400 s intervals. Binding curves involved the addition of 25 injections. The heat of dilution of the immunoagentsinto...

Báo cáo khoa học: Bioenergetic requirements of a Tat-dependent substrate in the halophilic archaeon Haloarcula hispanica pdf

... trans-lated in vitro using the pET vectors described above and the E. coli T7 S30 extract system. Reactions were per-formed in the presence of [35S]-methionine, according to the instructions of the ... independent of the PMF, and appears to depend on the SMF instead. In E. coli, and most likely also in other bacteria, the Tat systemdepends on the PMF [12]. Here we show involvement of the SMF in H. ... noted that the Dw normally forms only asmall part of the PMF in thylakoids. In bacteria,involvement of the PMF was ﬁrst shown throughinhibition of translocation of the precursor of the Escherichia...

Báo cáo khoa học: Protective effects of endomorphins, endogenous opioid peptides in the brain, on human low density lipoprotein oxidation pdf

... Inhibition of the increase in REM of LDL during the Cu2+-induced (A) or AAPH-initiated (B) peroxidation of LDL by endo-morphins and GSH. LDL (0.5 mg proteinÆmL)1) in NaCl ⁄ Piwas incu-bated ... Cu2+-treatedband in lane 2, a discernible increase in the intensity of bands was noted with the addition of 10, 20 and 40 lm EM1 (Fig. 6A, lane 3–5). Treatment of apoBwith 40 lm EM1, EM2 and GSH in the ... ResearchFund for the Doctoral Program in Higher EducationInstitution of the Ministry of Education of China for ﬁnancial support.References1 Beal MF (2002) Oxidatively modiﬁed proteins in agingand...

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