Báo cáo khoa học: " Cisplatin chemotherapy (without erythropoietin) and risk of life-threatening thromboembolic events in carcinoma of the uterine cervix: the tip of the iceberg? A review of the literature" docx

... Access Review Cisplatin chemotherapy (without erythropoietin) and risk of life-threatening thromboembolic events in carcinoma of the uterine cervix: the tip of the iceberg? A review of the literatureJon C Anders1, ... [15-17]Through vascular injury and possible alterations in the clotting cascade, chemotherapy agents such as cisplatin have the ability to affect coagulability and cause vascularinjury, two aspects of Virchow's ... WA, et al.: Concurrent chemotherapy and pelvic radia-tion therapy compared with pelvic radiation therapy aloneas adjuvant therapy after radical surgery in high -risk early-stage cancer of the...

Báo cáo khoa học: MicroRNA-143 reduces viability and increases sensitivity to 5-ﬂuorouracil in HCT116 human colorectal cancer cells potx

... is activated and acts as a survival factor in mitosis. Cell Signal 19, 1964–1972.31 Nakagawa Y, Iinuma M, Naoe T, Nozawa Y & AkaoY (2007) Characterized mechanism of alpha-mangostin-induced ... in a widearray of human cancers, including colorectal cancer[3,4]. Nevertheless, the molecular signalling pathwaysmodulated by miRNAs, which play a role in colorectalcancer, as well as cancer ... [27] and found mainly in the cytoplasm, where it was more intense in the ascendingmore differentiated pre-apoptotic glandular cells than in the immature, proliferating cells at the bottom of crypts....

Báo cáo khoa học: Glycogen synthase kinase 3b and b-catenin pathway is involved in toll-like receptor 4-mediated NADPH oxidase 1 expression in macrophages ppt

... and the b-cate-nin pathway are crucial regulators in the balancebetween pro- and anti -in ammatory cytokine produc-tion [25]. Recently, this pathway was shown to havean essential role in inﬂammation ... Ya-mamoto Y, Kawai T, Teshima-Kondo S, Tanahashi T& Rokutan K (2009) Interleukin 10 inhibits interferongamma- and tumor necrosis factor alpha-stimulatedactivation of NADPH oxidase 1 in ... throughphosphorylation, and the inactivated GSK3b inhibits the degradation of b-catenin, promoting translocationinto the nucleus. It is hypothesized that the translocat-ed b-catenin forms a complex with a...

Báo cáo khoa học: Interaction with model membranes and pore formation by human steﬁn B – studying the native and preﬁbrillar states docx

... dissociation of the G4R and StB-wt was fast and almost complete within5 min, whereas the dissociation of StB-Y31 wasslower and a considerable amount of the proteinremained attached to the membranes.Planar ... concentration and the time course wasfollowed for 30 min. The permeabilization induced by the proteins was expressed as a percentage of the maximalpermeabilization obtained at the end of the assay ... character-ize the membrane interaction and pore-forming ability of three human steﬁn B variants in native and preﬁbr-illar states. The results of all of the biophysical approaches used in the...

Báo cáo khoa học: Redox-sensitive loops D and E regulate NADP(H) binding in domain III and domain I–domain III interactions in proton-translocating Escherichia coli transhydrogenase potx

... domain II spans the membrane, while domain I and III are hydrophilic and contain the binding sites forNAD(H) and NADP(H), respectively. Separately expresseddomain I and III together catalyze a ... also showed a decreased a nity for domain I. The results support an important and regulatory role of loops D and E in the binding of NADP(H) as well as in the inter-action between domain I and ... mutant. A careful analysis of the structure of ecIII revealed that a plausible explanation for the above observation is that the side-chains of G430-Y431 -A4 32 appear to be involved in speciﬁc interactions...

Báo cáo khoa học: "FRENCH ORDER WITHOUT ORDER" pot

... fied. Note in particular that the MClass of the resulting sign is the MClass of the argument, that Lastright which indicates the morphological class ofthelast sign to have combined with the verb ... as advocated in COszkoreit 1987) and (Karttunen 1986). 1. UCG In UCG, the phonological, categorial, semantic and order information associated with a word is contained in a single grammar ... to be no clear regularities go- verning the relative ordering of a sequence of argu- ments. That is, assuming that only adjacent consti- tuents may combine and taking the combinations left-...

Báo cáo khoa học: "Machine Translation without Words through Substring Alignment" pdf

... probability of generating all spansother than a k, as in A* search for CFGs (Klein and Manning, 2003), and tic-tac-toe pruning for word-based ITGs (Zhang and Gildea, 2005). As the cal-culation of the ... probabilities are calcu-lated for e and f independently, and can be calcu-lated in n2time by processing each α in ascendingorder, and each β in descending order in a fashionsimilar to that of the ... Neubig1,2, Taro Watanabe2, Shinsuke Mori1, Tatsuya Kawahara11Graduate School of Informatics, Kyoto UniversityYoshida Honmachi, Sakyo-ku, Kyoto, Japan2National Institute of Information and Communication...

Báo cáo khóa học: Ouabain stimulates endothelin release and expression in human endothelial cells without inhibiting the sodium pump Robert Saunders and Georgios Scheiner-Bobis pptx

... 6).MAP kinase activation by ouabain In rat cardiomyocytes, ouabain has been shown tostimulate the MAP kinase reaction cascade [20,21]. Toinvestigate a similar mechanism in endothelial cells, MAPkinase ... was clearly detectable in HUAECs after 30 min of stimulation (Fig. 4A) . The increase in the phosphorylated MAP kinase forms is notdue to an increase in overall MAP kinase in the variouspreparations, ... might induce MAPkinase activation independently of ouabain.Ouabain was added to the cells at various concentra-tions in ECGM-SF, and the cells were further incubatedat 37 °C for 30 min. The...

báo cáo khoa học: "Esthesioneuroblastoma chemotherapy and radiotherapy for extensive disease: a case report" ppt

... involvement of the nasal cavities, nasopharynx, paranasal sinuses and orbit. Endoscopic excision of the mass was done. Traditionally the mainstay of treatment in such locally advanced patients is craniofacial ... 6% of nasal cavity and paranasal sinus neoplasms and 0.3% of the upper aero digestive tract malignancies [1]. Treatment recommendations range from a minimally invasive approach to combined ... response and disease free survival of 5 years. Presently our patient is clinically and radiologically free of disease. Craniofacial surgery is the mainstay of treatment in ENB regardless of stage and...

Báo cáo khoa học: "Central pancreatectomy without anastomosis" ppsx

... Journal of Surgical OncologyOpen AccessTechnical innovationsCentral pancreatectomy without anastomosisMichael Wayne*, Siyamek Neragi-Miandoab, Franklin Kasmin, William Brown, Anil Pahuja and ... 2005 and May 2009. The surgicalindications, operative outcomes, and pathologic findings were analyzed.Results: All 10 lesions were in the neck of the pancreas and included: 2 branch intraductal ... mortality, and technical factors of distal pancreatectomy. Am J Surg2002, 183:237.25. Johnson MA, Rajendran S, Balachandar TG, Kannan DG, Jeswanth S,Ravichandran P, Surendran R: Central pancreatectomy...

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