... and arysulfatase B, an N-acetyl-galactosaminidase-4-sulfatase, but increasing the activity of acid phosphatase in normal and OA chondrocytes [66].Ascorbic acid can cross-link collagen and other ... In vitro, ascorbate and ascorbic acid increased protein and pro-teoglycan synthesis by articular chondrocytes [64,66,67] and increased the mRNA levels of type I and II collagen [64,68] and aggrecan and ... myristoleate), on vitamins and minerals (vitamins C, E, B3, and B12, boron, a cocktail of vitamins and selenium, and a cocktail of minerals), on plantextracts (bromelain, Rosa canina, Harpagophytum procum-bens,...