Báo cáo khoa học: "Weak expression of cyclooxygenase-2 is associated with poorer outcome in endemic nasopharyngeal carcinoma: analysis of data rom randomized trial between radiation alone versus concurrent chemo-radiation (SQNP-01)" pdf

... staining; 1–4, weak staining; 5–8, moderate staining;and 9–12, strong staining. For the purpose of statistical analysis, the cohort was grouped into tumors with negli-gible or weak staining ... retrospective analysis of 58 samplesfrom patients, diagnosed with endemic NPC, who hadpreviously been randomized into a trial of radiotherapy(RT) alone versus concurrent chemo -radiation (CRT) ... 1 of 7(page number not for citation purposes) Radiation OncologyOpen AccessResearchWeak expression of cyclooxygenase-2 is associated with poorer outcome in endemic nasopharyngeal carcinoma:...

Tài liệu Báo cáo khoa học: Experimental proof for a signal peptidase I like activity in Mycoplasma pneumoniae, but absence of a gene encoding a conserved bacterial type I SPase pdf

... site of the main adhesineP1 of M. pneumoniae. This is the only other M. pneu-moniae protein, of which the N-terminus of the matureprotein was experimentally determined. For this pro-tein, ... labeled within the intactprotein at its a-amino group and represents the aminoterminal amino acid of P40. The efﬁciency of thisreaction was quite high, as judged from the signalintensities of ... sequencingproves, that there is no trypsin cleavage site at theamino terminus of this peptide, as read from the genesequence, then this peptide is taken as the N-terminalpeptide of this protein...

Báo cáo khoa học: A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+ ppt

... address thisquestion. As shown in Fig. 1B, the distance between the two termini of the inserted Ca2+-binding sites in the model structure of the EF-hand of STIM1 is within15 A˚. Accordingly, ... population of the EF-hand motif in STIM1 is occupied by Ca2+.Removing the proposed Ca2+-coordinating residues in positions 1 and 3 of the EF-hand motif signiﬁcantlycompromised the metal-binding ... understandthe mechanism underlying the Ca2+-modulated func-tions of STIM1 is to investigate the site-speciﬁc Ca2+-binding properties of the EF-hand of STIM1. In thisstudy, we adopted a grafting approach...

Báo cáo khoa học: Alternative splicing produces an H-protein with better substrate properties for the P-protein of glycine decarboxylase doc

... for Pisum sativum and SynechocystisP-protein with H-protein from Flaveria trinervia, Arabidopsis thalianaor Synechocystis as substrate. H-proteins carrying an N-terminalextension of four amino ... H-protein only by the insertion of two additional alanyl residues near the N-terminus.Kinetic analysis of the these two H-proteins fully con-ﬁrmed our ﬁndings with the two Flaveria H-proteins,i.e. ... alternative insertion of two alanine residues at the N-ter-minus of the H-protein elevates the activity of P-protein by 20% in vitro,and could promote glycine decarboxylase activity in vivo.AbbreviationsGDC,...

Báo cáo khoa học: "Does the surgeon still have a role to play in the diagnosis and management of lymphomas?" docx

... thestage of disease in 42% of cases, up regulating in 28% anddown regulating in 14% of cases [2]. The procedure con-sisted of liver and lymph node biopsies together with splenectomy. In addition ... 5); inadequate (n = 4). The remaining 30patients proceeded to biopsy without FNAC. FNAC wasperformed in 18 of 23 patients with cervical lymphaden-opathy but in only 14 of 39 of individuals with ... presence of dual pathology and scle-rosis/fibrosis in involved nodes leading to insufficientdiagnostic material.Other disadvantages of FNAC are lack of material for anaccurate typing of lymphoma...

Báo cáo khoa học: CpG and LPS can interfere negatively with prion clearance in macrophage and microglial cells pdf

... staining was found in bothcell lines, showing that PrPSc is effectively internalizedby both cell lines, independent of stimulation and of surface PrPclevels. In addition, both cell linesharboured, ... Role of microglia in neuronal cell death in prion disease. Brain Pathol 8,449–457.35 Baker CA, Martin D & Manuelidis L (2002) Microgliafrom Creutzfeldt–Jakob disease-infected brains areinfectious ... dependent on the prion strainused for infection [33,34]. Microglial cells can containinfectivity in vivo and may disseminate prion infectivitywithin the brain during their migratory activities...

Báo cáo khoa học: Amyloid-b protoﬁbril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice docx

... the stained area of interest aspercentage of total tissue area.Biochemical Ab analysis Cortical and cerebellar brain tissues from perfused animalswere extracted at a ratio of 1 : 10 (tissue ... animals (n = 4) displaying such behaviorswere excluded.Histology and image analysis Mice were anesthetized with 0.4 mL of avertin(25 mgÆmL)1) and intracardially perfused with 0.9% salinesolution. ... Correlations were examined by linearregression analysis (GraphPad Software Inc.) with P- andr-values and 95% conﬁdence intervals included in thegraphs. P < 0.05 was considered statistically signiﬁcant.A....

Báo cáo khoa học: The mitochondrial protein frataxin is essential for heme biosynthesis in plants potx

... participation of frataxin in deliveringiron to heme synthesis is frequently mentioned in the lit-erature, scarce direct evidence exists on the role of thisprotein in the biogenesis of heme-containing ... Fe–S-containing proteins, a reduction of heme a and concomitantly the cytochrome oxidaseactivity, suggesting an important role of frataxin in thebiogenesis of heme-containing proteins [25].Although ... to FC for insertion of iron into the protoporphyrin ring during heme synthe-sis. Knocking down the expression of frataxin in human cells revealed signiﬁcant defects in the activity of several...

Báo cáo khoa học: "Pim-1 A serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis" potx

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Báo cáo y học: "Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study" pdf

... patients with a current remission versus active disease (either active disease with a previous remission or continuously active disease). *Only CRP values of oligoarthritis patients with active disease ... subgroups consisted of too few individuals to permit reliable statistic analysis. Of the218 remaining patients, 151 had oligoarthritis and 67 had pol-yarthritis. The patients were examined and interviewed ... seen in individuals with C1q deficiency. Because MBL andC1q are molecules with similar characteristics this mightexplain why during active disease CRP levels were increased in children in the...

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