Báo cáo khoa học: "Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: One step forward, and one step back" pot

... soon.Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: One step forward, and one step back?Radiation Oncology 2011, 6:115 doi:10.1186/1748-717X-6-115Stephanie E Combs (stephanie.combs@med.uni-heidelberg.de)Stefan ... associated with an increase in OS or PFS; both endpoints were comparable in patients with active MGMT or with MGMT silencing. The only subgroup of patients showing a significant impact of MGMT- promoter ... 32 min. Antibody incubation was followed by Ventana standard signal amplification, UltraWash, counterstaining with one drop of hematoxylin for 4 min and one drop of bluing reagent for 4 min....

báo cáo khoa học: "Prognostic significance of STAT3 and phosphorylated STAT3 in human soft tissue tumors - a clinicopathological analysis" ppt

... western blotting and RT-PCR and drafted the manuscript. LM, and KB, provided the clinical samples and collected clinical information and MRparticipated in the coordination of the study and helped ... slides were rinsed in phosphate-buffered saline, exposed to diaminobenzidine, and counterstained with Mayer’ s hematoxylin. For thetumor tissues, nuclear STAT3 and pSTAT3 (Tyr 705)staining were ... Representative Western blotting analysis of STAT3 and pSTAT3 in soft tissue tumor extracts. Increased expression of STAT3 and pSTAT3 were observed in high and intermediategrade soft tissue tumors compared...

Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding afﬁnity pptx

... antigen-binding affinity and the VH⁄ VLinteraction strength determined, fiveclones in the H39Q group showed both high antigen-binding affinity and strong VH⁄ VLinteraction. In Table 1. Result of ... enhancement in VH⁄ VLinteraction signifi-cantly improved the antigen-binding affinity of Fv,similarly to the level of scFv (Table 2).Some single VHdomains of anti-protein IgG, inclu-ding HyHEL-10 ... VLbinder, to describe the relationship, and also to iden-tify key residues in determining the interdomain inter-action strength.ResultsConstruction of an FR2 combinatorial libraryTo investigate...

Báo cáo khoa học: "Intensity modulated or fractionated stereotactic reirradiation in patients with recurrent nasopharyngeal cancer" doc

... control and overall survival in patients with acceptable toxicity in patients with less advanced recurrences. However, the achievable outcome is limited in patients with involvement of intracranial ... regarding the distribution of dose to organs at risk see table 3. Regular follow-upexaminations took place in our institution or in thereferring centers including at least clinical examination and ... Stereotactic intensity modulated radiationtherapy and inverse treatment planning for tumors of the head and neck region: clinical implementation of the step and shoot approach and first clinical results....

Báo cáo y học: "Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity" pps

... CD28 and binds to CD80 and CD86 with ahigher affinity. Membrane bound CTLA-4 acts by interfering with CD28/CD80-CD86 interactions by competitive binding and also by mediating a negative signal interfering ... orpreventing T cell regulation, leading finally to exacerbation of the disease [16,17].The main finding of our study is that there are increased levels of serum sCTLA-4 in patients with SpA, ... understand this increase in circulating sCTLA-4 in patients with SpA, we then evaluated intracellular CTLA-4expression. This analysis was performed in a representativenumber of patients and controls...

Báo cáo khoa học: "The significance of the Van Nuys prognostic index in the management of ductal carcinoma in situ" pps

... deter-mining outcome in invasive breast carcinoma [11], thevalue of similar prognostic indices has proved less clearcut in DCIS. The present study of 215 patients with DCIStreated with local ... fashion and are unlikely totransform into carcinoma during the patient's life-time[15] and as such it is unreasonable to indiscriminatelysubject the increasingly large number of women with screen ... regarding the benefit of radiotherapy after local excision of ductal carcinoma in situ(DCIS) continues. The Van Nuys Prognostic Index (VNPI) is thought to be a useful aid in deciding whichpatients...

Báo cáo hóa học: " Prognostic significance of Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma''''" doc

... ession of Oct4 and Sox2. Immunohistochemical s taining for Oct4 and Sox2 expression in hypopharyngeal squamous cellcarcinoma. Brown grains represent a positive signal (3, 3-diaminobenzidine staining). ... expression of Oct4 or Sox2Positive staining for Oct4 and Sox2, mainly localized in the nucleus, were observed in the cancer cells of tumortissues (Fig. 1). The distribution of immunostainingscores ... useful indicator for predicting the prognosis of hypopharyngeal squamous cell carcinoma.BackgroundHead and neck squamous cell carcinoma, includinghypopharyngeal squamous cell carcinoma, is one of...

báo cáo khoa học: "Clinical significance of preoperative serum interleukin-6 and C-reactive protein level in breast cancer patients" pot

... differences in serum CRP levelsbetween patients with lymph node metastasis and thosewithout lymph node metastasis (r = 0.690, P =0.000).The median levels of CRP increased with increasingstage, and ... correlation with the stage of the disease it mayindirectly correlate with the prognosis of the patientunlike that of CRP.Interleukin-6 (IL-6) is a multi-poietic cytokine thatinduces the growth and ... Kattan MW, Timme TL, Scardino PT, Thompson TC:Elevated levels of circulating interleukin-6 and transforming growthfactor-beta1 in patients with metastatic prostatic carcinoma. J Urol 1999,161:182-187.2....

Báo cáo khoa học: "Prognostic value of HMGB1 overexpression in resectable gastric adenocarcinomas" docx

... protein in the gastric adenocarcinomasExpression of HMGB1 protein was evaluated by usingimmunohistochemical staining. As a nonhistone DNA-binding protein, the expression of HMGB1 protein wasmainly ... incubated with biotinylated goat anti-rabbit antibodies and ExtrAvidin-conjugated horseradishperoxidase. Staining was developed with diaminobenzi-dine substrate and sections were counterstained with hematoxylin. ... defense in patients with col-orectal cancers, through inducing growth inhibition and apoptosis in macrophages[17,18]. HMGB1 can also influ-ence a variety of important cell types within the tumormicroenvironment,...

Báo cáo khoa hoc:" Adaptive significance of amylase polymorphism in Drosophila. Analysis of the association between tissue-specific expression and specific activity in Amy or Amy genotypes F S of Drosophila subobscura" ppt

... despitesimilarities in the protein structure, originate from changes in the polygeniccomplex of regulatory genes, examination of their variability is of importance.a-Amylase in Drosophila, ... the exis-tence of compensation between the number of active regions and the specific activity of a-amylase within Amys and AmyF lines. © Inra/Elsevier, ParisDrosophila ... wereanalysed within and between the Amys and AmyF genotypes. Line groupingwas performed according to deviations outside ± 2 standard errors (SE) fromthe mean value of the...

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