... worldwide in both men and women, especiallyin ageing populations. It ranks third as the cause ofdeath from carcinoma, surpassed only by lung and prostate neoplasms in men, and lung and breast can-cers ... proteins),cell communication and signal transduction (annexin),cellular reorganization and the cytoskeleton (tropo-myosin, tubulin and actin) and toxin catabolism and water deprivation (glutathione ... intensity score of‡ 2 with at least 50% of malignant cells showing positivestaining was used to classify tumours with high expression(or over-expression), and < 50% of malignant cells with staining...