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Báo cáo khoa học: "Postmastectomy irradiation in breast in breast cancer patients with T1-2 and 1-3 positive axillary lymph nodes: Is there a role for radiation therapy" ppsx

Báo cáo khoa học:

Báo cáo khoa học: "Postmastectomy irradiation in breast in breast cancer patients with T1-2 and 1-3 positive axillary lymph nodes: Is there a role for radiation therapy" ppsx

... nodesremains uncertain and is being examined in a rando-mized clinical trial”. Many surgeons and radiation oncol-ogist are not recommending PMRT to 1-3 axillary lymph node positive patients with a ... breast cancers. Cancer 1981, 48:1863-1872.doi:10.1186/1748-717X-6-28Cite this article as: Cosar et al.: Postmastectomy irradiation in breast in breast cancer patients with T1-2 and 1-3 positive axillary ... breast in breast cancer patients with T1-2 and 1-3 positive axillary lymph nodes: Is there a role for radiation therapy?Rusen Cosar1*, Cem Uzal1, Fusun Tokatli2, Bengu Denizli1, Mert Saynak1,...
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Tài liệu Báo cáo khoa học: Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies Alteration of substrate specificity by replacement of Asn149 with Asp docx

Tài liệu Báo cáo khoa học: Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies Alteration of substrate specificity by replacement of Asn149 with Asp docx

... spe-cificities, is considered for arginase and agmatinase[20]. Such substrate discrimination is particularlyimportant for mammalian arginase II and agmatinase,as both enzymes are mitochondrial and functionallydifferent ... rely mainly in substituents at C -a. This has been, in fact, demonstrated for arginase[38,39] and the same may be safely deduced for agma-tinase. Therefore, as an explanation for the low cata-lytic ... His120Asn, 5¢-TGGGTTGATGCCAATGCTGACATCAAC-3¢ for His145Asn and 5¢-TGACATCGACACACCCC-3¢ for Asn149Asp.Fluorescence spectra and thermal inactivationstudiesFluorescence measurements were made at...
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Báo cáo khoa học: Lipopolyamine treatment increases the efficacy of intoxication with saporin and an anticancer saporin conjugate doc

Báo cáo khoa học: Lipopolyamine treatment increases the efficacy of intoxication with saporin and an anticancer saporin conjugate doc

... 2007)doi:10.1111/j.1742-4658.2007.06008.xSaporin is a type I ribosome-inactivating protein that is often appended with a cell-binding domain to specifically target and kill cancer cells. Uroki-nase plasminogen activator (uPA)-saporin, ... (uPA)-saporin, for example, is an anticancertoxin that consists of a chemical conjugate between the human uPA and native saporin. Both saporin and uPA-saporin enter the target cell by endo-cytosis and ... (1996)Immunohistochemical localization of urokinase-typeplasminogen activator, type-1 plasminogen-activatorinhibitor, urokinase receptor and alpha(2)-macroglobu-lin receptor in human breast carcinomas....
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Báo cáo khoa học:

Báo cáo khoa học: "Postmastectomy locoregional recurrence and recurrence-free survival in breast cancer patients" pdf

... 84; range 2-140months) after initial treatment of patients with breast cancer via regular visit (annually) for discovering theLRR. In addition to routine clinical examination, diseaseassessment ... following lumpectomy and axillary dissection for node-negative breast cancer. J Natl Cancer Inst 1992, 84(9):683-689.22. Bloom HJ, Richardson WW: Histological grading and prognosis in breast cancer; ... of a diet very high in vegetables, fruit, and fiber and low in fat on prognosis following treatment for breast cancer: the Women's Healthy Eating and Living (WHEL) randomized trial. JAMA...
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Báo cáo khoa học:

Báo cáo khoa học: "Treatment of symptomatic macromastia in a breast unit" pdf

... Oncoplastic breast conserving surgery. Breast cancer and macromastia treated using a mammaplasty technique .A 58-year-old woman with large breasts who presented with aninvasive small ductal carcinoma ... Hospital “Marqués deValdecilla”, Avda Valdecilla s/n, 39008 Santander, Cantabria, Spain.3 Breast Cancer Unit, University of Cantabria, Hospital “Marqués de Valdecilla”, AvdaValdecilla s/n, ... had a small tumor located in the retro-inferior-areolar area of a large left breast. By using an onco-therapectic mam-maplasty (Wise pattern incision with superomedial pedi-cle for traslating...
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Báo cáo khoa học:

Báo cáo khoa học: "Dose volume histogram analysis of normal structures associated with accelerated partial breast irradiation delivered by high dose rate brachytherapy and comparison with whole breast external beam radiotherapy fields" potx

... VarianMedical Systems, Palo Alto, California, USA). Tangentfields were set up for each patient using standard medial(patient midline) and lateral (mid -axillary line) borders with appropriate ... not for citation purposes)BackgroundAccelerated partial breast irradiation (APBI) is increas-ingly being used as an alternative to whole breast irradia-tion following wide local excision in ... because the only alterna-tive treatment to partial breast irradiation with brachytherapy using the MammoSite catheter at this insti-tution was WBRT. Partial breast radiotherapy using EBRTwas...
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Tài liệu Báo cáo khoa học: Transient RNA–protein interactions in RNA folding docx

Tài liệu Báo cáo khoa học: Transient RNA–protein interactions in RNA folding docx

... RNAstructures, which is measurable in strand displacementassays, and may additionally accelerate annealing. Thehypothesis that RNA chaperones and annealers inter-act with their targets in a ... complementary pairs (A U and GÆC), and because, within RNA molecules, guanosine bases canpair with uridine bases without disrupting helical struc-tures, a single RNA sequence can adopt many alterna-tive ... kinetics and thermodynamicsituation. If the RNA chaperone also has annealingactivity, it can catalyze the strand displacement event in two ways: by destabilizing edges and bulges, and by favoring...
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Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf

Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf

... cytometry.Preparation and analysis of DNA and proteinextractsAfter the appropriate treatment, cellular DNA was isolatedfrom 3 · 106cells per sample, and analyzed for internucleo-lar fragmentation by agarose ... and phospho-eIF 2a (#9721) were from Cell Signaling. Horse-radish peroxidase-conjugated antibody against caspase-3(#610325) was from BD Pharmigen, and antibody againstb-actin (A5 441) was from Sigma.Statistical ... X-100 for 4 min, before being treated with 1.5 m hydrochloric acid for 10 min. Incorporation of BrdU into newly synthesizedDNA was detected with an antibody against BrdU (Sigma), and analysis was...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt

Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt

... 7p12-13 and codes for a 170kDa receptor tyrosine kinase. AllERBB proteins have four functional domains: anextracellular ligand-binding domain; a transmembranedomain; an intracellular tyrosine kinase ... kinase domain; and a C-terminal regulatory domain [2]. The extracellulardomain is subdivided further into four domains. Thetyrosine kinase domain consists of an N-lobe and a C-lobe, and ATP binds ... processing. This shedding is mediatedby ADAM (a disintegrin and metalloprotease) proteinsthat are membrane-anchored metalloproteases [4].Signal transduction by ERBB proteinsBinding of a family...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc

Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc

... phase II and translational study of cetuximab in metastatic colorectalcarcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines. J Clin Oncol 24, 4914–4921.3 Khambata-Ford S, Garrett ... Inoue A, Hagiwara K, Sunaga N,Yanagitani N, Hida T et al. (2009) Combined SurvivalAnalysis of Prospective Clinical Trials of Gefitinib for Non-Small Cell Lung Cancer with EGFR Mutations.Clin ... with adenocarcinoma than in those with other histological subtypes of cancer, and in indi-viduals who have never smoked than in those with a his-tory of smoking [10]. These clinical observations...
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