... examined the hypothesis that the
Framingham score is increased and associated with coronary-
artery atherosclerosis in patients with RA. The Framingham
score and the 10-year cardiovascular risk ... in the Framingham risk score
in patients and controls, and the majority of the SLE patients
with coronary calcification had a low 10-year ri...
... cells.
The second aim of the study was to determine whether
downregulation of phagocyte activities are involved in the
anti-inflammatory activity of anti-TNF-α therapy. The lack of
activity on ... observed in patients during adalimu-
mab therapy does not explain the decreased influx of neu-
trophils into synovial joints previously observed in RA
patients during...
... activity
to study the validity of the Disease Activity Score and the
DAS28. In a study performed in Italy in the late 1990s, it was
found that the Disease Activity Score was the best measure
to discriminate ... best the physician’s clinical judgement
of response to infliximab therapy in rheumatoid arthritis
patients: validation of the DAS28 score...
... regardless of the etiology of
such inadequacy. In contrast, vitamin B6 supplementation was
ineffective in suppressing inflammatory cytokine production, or
reducing ESR, plasma CRP or rheumatoid factor ... measured to examine the impact of
pyridoxine treatment on vitamin B6 excretion in these patients.
Pro-inflammatory cytokine (TNF-α and IL-6) production, C-
reactive pro...
... pro-inflammatory responses to painful
stimulation may play a deleterious role in shaping the long-term
symptomatology of RA.
Competing interests
The authors declare that they have no competing interests.
Authors' ... stressors on the physiology and symptomatology of
patients with RA. Collectively, laboratory research has docu-
mented a maladaptively pro-inflammatory res...
... incorporation of information from the clinical
examination reduces the utility of routine CXRs, with only
3.4% leading to a change in management. The majority of the
changes (78%) were related to repositioning ... radiography in a respiratory intensive care
unit. Chest 1985, 88:691-696.
6. Silverstein DS, Livingston DH, Elcavage J, Kovar L, Kelly KM: The
utility of...
... published
by the University of Toronto Press. Prior, he was a
student of psychology specialist at the University of
Toronto, being awarded an academic scholarship
from the University of Toronto. ... history can be obtained by asking the indi-
vidual “how many times do you laugh during your
regular day?” and have the individual rate their level
on a scale of one to...
... alignments with bacterial cytochromes
P450 has identified domains in the primary sequence of
human CYP17 which are involved in the catalytic activity of
the enzyme, i.e. substrate docking and binding, the ... conversion of PREG to DHEA, however, appears to
differ with respect to the interaction of the enzyme with the
17-hydroxylated intermediate. Baboon CY...
... regulation of a range of components of the
translational machinery, principally by changes in their
phosphorylation, leading to modulation of their activities or
their abilities to interact with one ... recycling of eIF2 to this
form [29,30]. The activity of eIF2B can be modulated in a
variety of ways [29,31] including by its own phosphoryla-
tion, and through ph...
... only partially soluble in five of the constructs
resulting in very poor yields. Intriguingly, in the sixth con-
struct, the yield of soluble fusion protein with an extended
carboxyl terminus of ... solubility of
fusion proteins is not necessarily indicative of either proper
folding or of increased solubility of the protein of interest.
We propose that the succ...