Báo cáo y học: "Methotrexate enhances the anti-inflammatory effect of CF101 via up-regulation of the A3 adenosine receptor expression" doc
Báo cáo y học: "Methotrexate enhances the anti-inflammatory effect of CF101 via up-regulation of the A3 adenosine receptor expression" doc
... via A2Aand the A3 adenosine receptors [8,9]. The highly selective A3 adenosine receptor (A3AR) agonist IB-MECA (1-deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-9-yl]-N-methyl-β-D-ribofura-nuronamide) ... 6Research articleMethotrexate enhances the anti-inflammatory effect of CF101 via up-regulation of the A3 adenosine receptor expressionAvivit Ochaion1,2, Sara Bar-Yehuda1, Shira Cohn1,2, ... the efficacy of the com-bined treatment, we first examined the mode of action of MTX.It acts as an antagonist of folic acid, subsequently inhibiting the synthesis of purines and pyrimidines....
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Báo cáo y học: "Methotrexate therapy associates with reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60- more than just an anti-inflammatory effect? A cross sectional study" pptx
... significantly higher rates of the MetS [40]. This discrepancy may be a consequence of the ongoing inflammatory burden in the RA population, alteringsome of the components of the metabolic syndrome. The ... be the keyto the underlying pathophysiology of the MetS, and canimprove with folate replacement therapy [53]. Thus, suppres-sion of a potential precipitant (homocysteine) via the use of folic ... other components of the MetS had anon-significant association (data not shown).In addition to the originality of most of the findings, this studyhas several other strengths. These include the...
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Báo cáo y học: "Neurturin enhances the recovery of erectile function following bilateral cavernous nerve crush injury in the rat" ppsx
... neurons. We present the first in vivo report of the effects of neurturin upon the recovery of erectilefunction following bilateral cavernous nerve crush injury in the rat.Methods: In these experiments, ... oxide (NO) is synthesized, their loss after nerveinjury is therefore chiefly responsible for the development of ED. Using this animal model of neurogenic ED, wehave previously demonstrated ... Inthis study, the in vivo neuromodulatory effects of neur-turin upon the recovery of erectile function followingbilateral cavernous nerve crush injury are demonstratedusing a rat model of neurogenic...
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Báo cáo y học: "Parvovirus B19 Genotype Specific Amino Acid Substitution in NS1 Reduces the Protein’s Cytotoxicity in Culture"
... 23). On the other hand, the non-structural protein of B19 (NS1) is a candidate mediator of direct cell injury. B19 virus targets erythroid cells via the major host cell receptor glycolipid ... To test the hypo-thesis that B19-associated liver pathology is related to the direct toxicity of persistent B19 NS1 in hepatocytes of previously infected individuals, we examined the possible ... software (Becton-Dickson), and statistical analysis completed by FlowJo software (Tree Star, Inc, Ash-land, OR). Cytotoxicity Assay. Trypan blue dye exclusion was used to determine cell viability....
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Báo cáo y học: "Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects"
... Frequency of the MTHFR genotypes and the result of the Chi square testing in the different studied groups. Showing the frequency and the results of the cross tabulation of the T allele and the different ... the thermolability of MTHFR. Actually, the frequency of the mutated allele was quite high, depending on the ethnic group analyzed [18-21]. Some authors suggested that the homozygosity for the ... difference in the occurrence of the TT genotype in any of the studied groups (P>0.05). Also the prevalence of the different genotypes did not deviate from the Hardy–Weinberg equilibrium for the control...
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Tài liệu Báo cáo Y học: Granule-bound starch synthase I A major enzyme involved in the biogenesis of B-crystallites in starch granules ppt
... followed the kinetics of amylose synthesis overa 5-day period of nitrogen starvation and measured the amounts of starch, amylose, the kmax of the starchfractions, the degree of crystallinity and the ... course of storage starch synthesis show that amylopectin and amylosesynthesis are partly disconnected and that amylose synthesispersists when the rate of polysaccharide and amylopectinsynthesis ... issynthesized in vivo when the rate of amylopectin synthesisbecomes minimal. At these moments the rates of amylopec-tin synthesis are only 5% of their maximal values. In fact thislow rate of...
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Báo cáo Y học: Amino acids 3–13 and amino acids in and flanking the 23FxxLF27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor pdf
... AR3)13deletion,whereas in the mammalian assay almost all reporter geneactivity was lost. The most obvious difference betweenboth assays is the coupling of AR.NTD to GalAD in the yeast assay, and the absence of a ... a-helix;FxxLF. The androgen receptor (AR) is a member of the steroid receptor subgroup of the nuclear receptor family of transcription factors. Nuclear receptors have a modularstructure, composed of a ... regulation of AR function. Detailedknowledge on the role of the AR N/C interaction wouldrequire the elucidation of its function under more physio-logical conditions, including the study of mouse...
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Báo cáo Y học: Guanosine diphosphate-4-keto-6-deoxy-D-mannose reductase in the pathway for the synthesis of GDP-6-deoxy-D-talose in Actinobacillus actinomycetemcomitans potx
... content of 48.0% [43]. The GC content of the region essential for the biosynthesis of SPA in the otherserotype strains (b–e) of A. actinomycetemcomitans is alsolower than the average GC content of ... chromatograph spectra of the acetylatedD-(+)-2-octyl glycosides obtained from the hydrolysate of the purified GDP-6-deoxytalose. (A) Glycosides of the purified serotype a-specific poly-saccharide antigen ... H]+ion of GDP-6-deoxy-D-talose.1H NMR analysis of the structure of the purifiedGDP-6-deoxyhexoseApproximately 2 mg of the sugar nucleotide obtainedfrom the enzyme assay using the gmd and tld...
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Báo cáo Y học: A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor potx
... 0.12pY429pY431 1.1 ± 0.03F429pY431 4.6 ± 0.02pY429F431 4.9 ± 0.02 Y4 2 9Y4 31 NDpY443 NDpY461pY464 ND Y4 61pY464 NDpY46 1Y4 64 NDpY479 NDÓ FEBS 2002 SOCS-3 binds to the pY429pY431 motif of Epo-R (Eur. J. ... phosphorylatedpeptide pY429pY431 (pYpY). In comparison, the muta-tion only marginally reduces the interaction with the single phosphorylated peptides pY429F431 (pYF) andF429pY431 (FpY) suggesting ... tyrosines Y5 79 and Y5 81 to recruit and activate the kinases of the Src familymore potently than the corresponding single phosphorylatedmotifs. The authors discuss the phosphorylation of tyrosine Y5 81...
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Báo cáo Y học: Cytochrome c from a thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability potx
... aheme covalently attached to the polypeptide chain via twothioether bonds, formed from the vinyl groups of the hemeand the two cysteine residues in the consensus Cys-X-X-Cys-His motif [1–4]. ... T., Yamazaki, K., Kyogoku, Y. &Kobayashi, Y. (1998) Solution structure of thermostable cyto-chrome c-552 from Hydrogenobacter thermophilus determined by1H-NMR spectroscopy. Biochemistry ... indicatedby the presence of a typical signal peptide in the precursor of bacterial soluble cytochrome c. Requirement of the signal peptide was experimentally verified byheterologous gene expression of...
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