Báo cáo y học: "Targeting B cells in systemic lupus erythematosus: not just déjà vu all over again" pdf

... would probably not be acceptable foruse in SLE. Another curious finding in the lymphomaexperience is that combining epratuzumab with rituximab,although not increasing the overall clinical response ... thatepratuzumab will be shown to improve SLE clinically, then thelack of biological markers of its effects may in fact be adrawback to its rational use. Because even the fall in B cells in peripheral blood ... true ofrituximab [1].It is unfortunate that there is only limited preclinicalinformation available on the signaling mediated byepratuzumab binding to CD22 on various subsets of B cells [9]. Several...

Báo cáo y học: "Regulatory T cells in systemic lupus erythematosus: past, present and future" pot

... not only is responsible forTreg differentiation, but also prevents these cells frombecoming Th17 proinflammatory effector cells. Depletion ofReviewRegulatory T cells in systemic lupus erythematosus: ... [84] expressed by DCs, and the proinflammatory cytokinesproduced by activated T cells, continuously stimulateimmature DC to become immunogenic antigen-presenting cells. These cells, in turn, activate ... controversial results concerningpercentages of Foxp3+CD4+ cells and correlations withdisease activity in SLE may be explained by a variability ofdisease activity in the patients studied. Investigators...

Báo cáo y học: "Development and management of systemic lupus erythematosus in an HIV-infected man with hepatitis C and B co-infection following interferon therapy: a case report" doc

... INF-producing pDCs during HIV infection [13] may contributeto this protective effect of HIV. DCs can be infected by HIV,and TLR9 signalling-changes in pDC function may bereduced indirectly by HIV ... pDC in HIVinfection usually parallels the loss of CD4 [15], but the rateof recovery of DC and CD4 T cells may be independent.What factors may have been important in the develop-ment of SLE in ... 2. Changes in viral load and lymphocytes pre and posttherapy. A: summary of therapy. B: lymphocyte subsetnumbers and C: lymphocyte proportion during ART and in response to splenectomy and anti-retroviral...

Báo cáo y học: "Is closer linkage between systemic lupus erythematosus and anti-double-stranded DNA antibodies a desirable and attainable goal" ppsx

... focusing on the organ specificity of anti-dsDNAantibody-mediated injury.Anti-dsDNA antibodies and lupus pathophysiologyAnti-dsDNA antibodies and SLE pathophysiology arecurrently quite loosely ... cutaneous lupus erythematosus [14], there is littleevidence that anti-dsDNA antibodies are pathophysio-logically involved in other clinical manifestations. Recentfindings that intrathecal binding ... antibodies occurs. If anti-DNA antibodypathogenicity is determined by the interaction betweenantibody and tissue-specific antigens, the selectionprinciple and/or the organ-specific binding...

Báo cáo y học: "Replication of recently identified systemic lupus erythematosus genetic associations: a case–control study" pps

... Janus-family tyrosine kinase that is bound to cytokinereceptors and becomes activated after ligand binding. Defi-ciency of TYK2 leads to defects of multiple cytokine pathways,including type I interferon, ... protein with ankyrin repeats 1; BLK: B- lymphoid tyrosine kinase; GWA: genome-wide association; IL: interleukin; ITGAM: integrin alpha M; LY9: lymphocyte antigen 9; MECP2: methyl CpG binding protein ... geno-type calls were manually reviewed and conflicting results wereliberally re-assayed or re-genotyped by sequencing with theBig Dye Ready Reaction Kit v 3.1 (Applied Biosystems).Sequence reactions...

báo cáo khoa học: "Paroxysmal nocturnal hemoglobinuria in systemic lupus erythematosus: a case report" ppt

... hemolytic anemia due to the increased susceptibility of the erythrocyte membrane to complement-mediated lysis; (b) thrombosis in large vessels, such as hepatic, abdominal, cerebral, and subdermal ... proteinuria with serological and hematological abnormalities – the titers of anti-nuclear antibody and double-stranded DNA (dsDNA) antibody Paroxysmal nocturnal hemoglobinuria in systemic lupus ... Systemic lupus erythematosus with paroxysmal nocturnal hemoglobinuria is very rare. We report a case of paroxysmal nocturnal hemoglobinuria that developed in a patient with systemic lupus erythematosus...

Báo cáo y học: "Preventive health services for systemic lupus erythematosus patients: whose job is it" pps

... system, such as the one we currently have in the US. us, it is gratifying to note the study by Yazdany and colleagues [1] in this issue of Arthritis Research &  erapy. In this study ... particularly if the latter assumes incorrectly that all health-related issues (preventive services included) are being taken care of by the former. Such assumptions are not uncommon in a less-than-ideal ... discussion, lupus patients are at increased risk of both infections and AbstractApropos of the article about preventive health care for patients with systemic lupus erythematosus in this issue...

Báo cáo y học: " Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of B-cells in systemic lupus erythematosus" potx

... fragment binding. T -cells did not show any epratuzumab binding and were subsequentlyused as negative control. Notably, we did not observeany significant inhibition of epratuzumab binding onmonocytes ... H7-allophycocyanin; ITIMs:immunoreceptor tyrosine-based inhibitory motifs; mAb: monoclonalantibody; MFI: mean fluorescence intensity; MIG: monokine induced bygamma interferon; PB: pacific blue; PBMCs: ... peripheral blood mononuclear cells; PBS: phosphate-buffered saline; PE: phycoerythrin; PE-Cy7:phycoerythrin-cyanin 7; PerCP: peridin chlorophyll protein; Siglec-2: Sialicacid-binding Ig-like lectin...

Báo cáo y học: "egulatory T cells in rheumatoid arthritis" ppsx

... of T effector cells to the suppressiveeffects of Tregs [54]. Finally, although suppression by Tregsis probably not antigen-specific but might involve neighboringT cells in a ‘bystander’ fashion ... Khoury SJ, Weiner HL,Hafler DA: Induction of circulating myelin basic protein andproteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin ... with RA. Synovial Tregs expressan increased regulatory capacity in comparison with Tregsderived from the peripheral blood, in assays in vitro. In thesynovium, Tregs might be inhibited by different...

Báo cáo y học: "TH-17 cells in rheumatoid arthritis" pdf

... ionomyocin (1 μg/ml) plusbrefeldin A (10 μg/ml) for four hours. Cells were blocked with50% human serum and 0.5% bovine serum albumin in phos-phate buffered saline and incubated with allophycocyanin-conjugated ... critical role in the pathogenesisof rheumatoid arthritis (RA). IL-17 is capable of promotinginflammation by inducing a variety of pro-inflammatory media-tors, including cytokines, chemokines and ... followed by stimulation with phorbol myristate acetate (PMA)plus ionomycin (P/I). The abundance of TH-17 cells in RA SFwas determined by flow cytometry. IL-17 levels were quantified in synovial...

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