Báo cáo y học: "Association of PTPN22 1858 single-nucleotide polymorphism with rheumatoid arthritis in a German cohort: higher frequency of the risk allele in male compared to female patients" potx
... significantly
shorter in the CCI rats compared with sham controls.
Mechanical allodynia and thermal hyperalgesia in-
duced by CCI was attenuated by intrathecal adminis-
tration with TLR4 -siRNA (p<0.05, ... Conclusions/Significance: These
findings suggest that suppression of TLR4 mediated by intrathecally administered siRNA may
be a new strategy for the treatment of neuro...
... and weight gain among
psychiatric outpatients in Pakistan: a retrospective cohort study
Syed Ahmer*
1
, Rashid AM Khan
1
and Saleem Perwaiz Iqbal
2
Address:
1
Department of Psychiatry, Aga ... Aga Khan University, Karachi, Pakistan and
2
Department of Paediatrics & Child Health, Aga Khan University,
Karachi, Pakistan
Email: Syed Ahmer* - syed.ahmer@aku.edu; R...
... not for citation purposes)
Vol 10 No 6
Research article
Antibodies to mutated citrullinated vimentin for diagnosing
rheumatoid arthritis in anti-CCP-negative patients and for
monitoring infliximab ... enzyme immunoassay; ELISA: enzyme-linked immunosorb-
ent assay; MCV: mutated citrullinated vimentin; PTPN22: protein tyrosine phosphatase nonreceptor type 22...
... transfer to synoviocytes and
osteoclasts. J Clin Invest 1999, 104:137-146.
14. Pap T, Franz JK, Hummel KM, Jeisy E, Gay RE, Gay S: Activation
of synovial fibroblasts in rheumatoid arthritis: lack ... cultured rheumatoid synoviocytes. J
Rheumatol 1995, 22:817-828.
12. Morel JC, Park CC, Zhu K, Kumar P, Ruth JH, Koch AE: Signal
transduction pathways involved in rheumatoid arthritis s...
... 5
Research article
Improved cartilage integration and interfacial strength after
enzymatic treatment in a cartilage transplantation model
Jarno van de Breevaart Bravenboer
1
, Caroline D In der Maur
2
, ... constructs.
Discussion
In the present study we found an improvement in histologi-
cal and biomechanical integration of articular cartilage after
trea...
... single-nucleotide polymorphism with
rheumatoid arthritis in a German cohort: higher frequency of the
risk allele in male compared to female patients
Matthias Pierer, Sylke Kaltenhäuser, Sybille Arnold, Matthias ... provide
further evidence that the PTPN22 1858T allele is associated
with RA irrespective of autoantibody production. The increas...
... released in increased amounts in response
to growth factors and proinflammatory cytokines, suggesting
involvement in the pathophysiology of RA [24]. The few stud-
ies of anti-MCV usually found performance ... widely expressed
by mesenchymal cells and macrophages and easy to detect in
the synovium. Modification of the protein occurs in macro-
phages undergoing apoptosis, a...
... substance as an
antivenom is both historically ancient and geographically
Table 3 Charms related to snakebites, according to the inhabitants of the county of Pedra Branca, Bahia State, Brazil.
Charms ... pricking are synonymous and used as
equivalent to offending. In this artic le, the word offense
means a direct injury, real and/ or imaginary, caused by
any animal to a...
... bypas s (CPB) was achieved by standard
ascending aorta and bicaval cannulation. Mildly
hypothermic (32°C) CPB was established. Cold blood car-
dioplegia was administered in an antegrade fashion
through ... triatriatum. Cathet Cardiovasc Diagn 1992, 25:323-6.
doi:10.1186/1749-8090-6-83
Cite this article as: Kokotsakis et al.: Cor triatriatum presenting as heart
failure with redu...
... CAS E REP O R T Open Access
Delayed intracardial shunting and hypoxemia
after massive pulmonary embolism in a patient
with a biventricular assist device
Thomas Weig
1*
, Michael E Dolch
1
, ... months
postpartum on a cardiac biventricular assist device (BVAD) as bridge to heart transplantation with delayed onset of
intracardial shunting and subseque...
... purposes)
Journal of Medical Case Reports
Open Access
Case report
Association between isotretinoin use and central retinal vein
occlusion in an adolescent with minor predisposition for thrombotic
incidents: ... documented case of this association.
Case presentation: An otherwise healthy 17-year-old white man who was treated with systemic
isotreti...
... purposes)
NTHi-induced COX-2 and PGE2 expression mediated by
p38 MAPK and NF-kappa B signaling pathway
To determine the role of NTHi-induced p38 MAPK and
NF-kappa B activations in NTHi-induced COX-2 and
PGE2 ... the inhibition of p38 MAPK.
Conclusion: NTHi induces COX-2 and PGE2 expression in a p38 MAPK and NF-kappa B-dependent manne...
... (65.5%).
Dermatophagoides pteronyssinus (Dpt) was the causative
allergen in 62, Dermatophagoides farinae (Df) in 58, cat
hair dander in 23 and dog hair dander in 9 patients (some
patients were allergic ... because C3 and C4 levels were within the
normal range in all patients tested (Table 1). In support of
the lack of involvement of the classical and lectin...
... Silva et al., Hypervolemia induces and potentiates lung
damage after recruitment maneuver in a model of sepsis-induced acute
lung injury Critical Care 2010, 14:R114
Silva et al. Critical Care ... 68:585-618.
33. Kulkarni AC, Kuppusamy P, Parinandi N: Oxygen, the lead actor in the
pathophysiologic drama: enactment of the trinity of normoxia,
hypoxia, and...
... procalcitonin to determine its
association with sCD40L levels. There are been reported
an association between sCD40L levels and severity of
acute coronary artery syndrome [31] and between tropo-
nin and ... associated with mor-
tality at 30 days in a large series of septic patients.
We found higher serum sCD40L levels in patients
with severe sepsis than in h...