Báo cáo y học: "α The role of HIF-1α in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis" pot

... conditions.Using RNA-interference, Yudoh and colleagues [1] furtheranalyzed the role of HIF-1 in chondrocytic energy generation,matrix synthesis and cell survival. During hypoxic and normoxic ... celldeath induced by pro-inflammatory cytokines. Finally, Yudoh and colleagues showed that HIF-1α is necessary foranaerobic energy generation and proteoglycan synthesis byarticular chondrocytes, ... functional inactivation of HIF-1α in the presence of interleukin-1β resulted in a significantly increasednumber of apoptotic chondrocytes. These in vitro data are in accordance with the in vivo...

Báo cáo y học: "Apolipoprotein A-I infiltration in rheumatoid arthritis synovial tissue: a control mechanism of cytokine production" pot

... production.This study examined the hypothesis that apoA-I may have aregulatory role at sites of macrophage activation by Tlymphocytes in inflamed RA synovial tissue. Synovial tissuesamples were obtained ... of inflammatory cells, including monocytes and lymphocytes[1]. It has been proposed that the first cells to infiltrate syn-ovial tissue are T lymphocytes, suggesting that they havean important role in pathogenesis. ... beenconfirmed by others (for review see [2]). The unregulatedproduction of IL-1β and TNF-α in RA has been recognizedfor several years, and their role in the pathophysiology hasbeen confirmed by the demonstration...

Báo cáo y học: "Extra corporal membrane oxygenation in general thoracic surgery: a new single veno-venous cannulatio" potx

... case report and accompanyingimages. A copy of the written consent is available forreview by the Editor -in- Chief of this journal.AcknowledgementsSylvain Tuaudé, I.S.T CARDIOLOGY for his technical ... 87(3):854-60.4. Jeon HK, So YK, Yang JH, Jeong HS: Extracorporeal oxygenation supportfor curative surgery in a patient with papillary thyroid carcinomainvading the trachea. J Laryngol Otol 2009, 123(7):807-10.5. ... wrote the article.JS participated in its design, writing process and bibliographyMS, KA, participated in its coordination and correction on the surgical part.RK participated in its coordination...

Báo cáo y học: " Recurrent spontaneous hip dislocation in a patient with neurofibromatosis type 1: a case report" potx

... 4 cm enhancing mass at the superioraspect of the left acetabulum extending into the l eft hipjoint (Figure 3). There was smooth e rosion of the neck of the femur but the head of the femur appeared ... to the instability of the hip joint. The soft tis-sue swelling responsible for these abnormalities isclearly demonstra ted on the MRI scan (Figure 3). Therewere no spinal-tumors displayed ... anaesthetic and this was maintained with skin traction. A computedtomography (CT) of her pelvis displayed a smooth ero-sion of the lateral margin of her left ileum and femoralneck, markedly increased...

Báo cáo y học: "Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF-1 in cultured rat nucleus pulposus cells" ppsx

... high and constant level of c-Myc. Also, the contribution of Ras/Raf/ERK prevented the rapid degradation of c-Myc byphosphorylation of the serine 62 residue in the N-terminal of c-Myc [24]. They ... hypothesizedthat c-Myc plays a central role in TGF1 signaling for cellgrowth stimulation. Additionally, to examine the possibility of involvement of the MAPK pathway in regulation of c-Myc sta-bility, we ... under the growth inhibitory effect of TGF1 [29-32]. The aim of the present study was therefore to reveal the role of c-Myc in mitogenic response to TGF1 in nucleus pulposuscells. The study was...

Báo cáo y học: "Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice" doc

... reported on the role of cytokines in RP,either in patients or in the corresponding animal models. In the CIA model, several cytokines have been shown to playmajor roles in the inflammatory process, ... for the induction of clinical symptoms [16,17]. In addi-tion, the complement system plays a major role in the pathogenesis of both diseases [16,18,19] and T cells arerequired in order to induce ... scores. However, the symp-toms in these strains did not proceed in relapses as theydid in the QD and B10.Q mice, and therefore resulted in alower mean score than for the other strains (Fig. 1c).Table...

Báo cáo y học: "4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase" doc

... as the major energy substrate for articular chondro-cytes and as the main precursor for the synthesis of ECM gly-cosaminoglycans in cartilage [35,36]. The inhibition of proteoglycan synthesis ... goal of clarifyingthis role, we documented the ability of HNE to modulate mark-ers of apoptosis, redox status, and energy metabolism of chondrocytes. Then, we investigated the potential role of ... functions mayelicit the increased production of reactive oxygen species(ROS) in chondrocytes. Besides causing degradation [7] orinhibiting the synthesis of cartilage matrix [8], ROS may inducechondrocyte...

Báo cáo y học: "IV among pregnant women in Moshi Tanzania: the role of sexual behavior, male partner characteristics and sexually transmitted infections" pot

... disruption of the mucosa barrier, thus provid-ing an easy port of entry and increase the recruitment and activation of HIV susceptible inflammatory cells. The inflammation and ulceration increases ... Institute of General Practice and Community Medicine, University of Oslo, Norway, 2Department of Obstetric and Gynaecology, Rikshospitalet University Hospital, University of Oslo, Norway and ... decreased trend in the prevalence and inci-dence of HIV, especially among individuals aged 15–24years [3,4]. In others, there is a gradual and continuingspread of HIV [4,5]. In all areas however,...

Báo cáo y học: "A role of ygfZ in the Escherichia coli response to plumbagin challenge" pdf

... of YgfZ followed byFigure 2 Different roles played by YgfZ and SodA in counteracting plumbagin. The ΔygfZ and ΔsodA strains were transformed with pQE-sodA and pQE-ygfZ to express SodA and YgfZ, ... and the Δyg fZstrains and the parental strain were tested (Table 3).Therefore, adding a methyl group to the 3-position of naphtho quinone ring apparently diminishes the plumba-gin toxicity ... activities of different YgfZ constructs to support the growth of the ΔygfZ E. coli strain in the presence of plumbagin. Plasmids were separately transformed into the ΔygfZ strain and assayed for the diameters...

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