Báo cáo y học: "Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthriti" docx
Báo cáo y học: "Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthriti" docx
... human FAPα were: 5'-ATC-TATGACCTTAGCAATGGAGAATTTGT-3' and 5'-GTTTT-GATAGACATATGCTAATTTACTCCCAAC-3'. The primersused for bovine FAPα were 5'-ACCATGAAAAGTGTGAAT-GCTTCA-3' ... FAPα is expressed in many pathologies.FAPα is a type II transmembrane serine proteinase with a cyto-plasmic tail that contains six amino acids followed by a 20amino acid transmembrane domain ... assayed as a meas-ure of collagen degradation [10] and glycosaminoglycanrelease was assayed as a measure of proteoglycan degrada-tion [10]. Collagenase activity was determined by the 3H-acetylated...
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Báo cáo y học: "Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes" ppt
... arthritis (RA) is a chronic inflammatory disease ofunknown aetiology and is characterised by hyperplasia and chronic inflammation of the synovial membranes that invadedeeply into the articular cartilage ... prod-uct was generated with 5'-CTGAAGGTGATGAAGCAGCC-3' and 5'-AGTCCAAGAGAATGGCCGAG-3'. The MMP-13PCR product was generated with 5'-CTATGGTCCAGGA-GATGAAG-3' and 5'-AGAGTCTTGCCTGTATCCTC-3'. ... humanFigure 7Double-staining of fibroblast activation protein (FAP) and smooth muscle actin (SMA)Double-staining of fibroblast activation protein (FAP) and smooth muscle actin (SMA). Synovial...
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Báo cáo y học: "The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes" ppt
... pathologies of RA and OAdiffer, it is clear that in both of these diseases pro-inflam-matory cytokines are present, resulting in an inflammatorystate as well as cartilage degradation [14]. As further ... of pro-inflammatory cytokines in RA,anti-tumor necrosis factor-α (anti-TNF-α) and anti-inter-leukin 1 (anti-IL-1) therapies can reduce inflammation and retard the progression of disease as assessed ... chondro-cytes that respond to biochemical and physical stimuli tomaintain this tissue. Cartilage is primarily composed of type IIcollagen and proteoglycan, which are synthesized by the chondrocytes. ...
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Báo cáo y học: "Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription-1 (STAT-1)" ppt
... RA.IndroductionHuman rheumatoid arthritis (RA) is a chronic systemic disor-der of unknown aetiology, characterized by intimal lining layerhyperplasia, infiltration of the sublining area by macrophages,T and ... IL-6 and TNF-α areupregulated in RA as well as in AIA [20]. In sera, IL-6 was ele-vated in the acute phase (day 3) of AIA in comparison to non-arthritic, immunized animals (day 0 of AIA), and ... Ganea D: Inhibition of IFN-gamma-induced januskinase-1-STAT1 activation in macrophages by vasoactiveintestinal peptide and pituitary adenylate cyclase-activatingpolypeptide. J Immunol 2000,...
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Báo cáo y học: "Genome-wide analysis of the diatom cell cycle unveils a novel type of cyclins involved in environmental signaling" pptx
... (21159)Homsa;CYCG1Homsa;CYCG2Arath;CYCD4;1Arath;CYCD2;1Homsa;CYCJHomsa;CYCE2Arath;CYCB1;1Arath;CYCB3;1Thaps (36441)Phatr;CYCP6Phatr;CYCP4Phatr;CYCP1Phatr;CYCP5Phatr;CYCP3Phatr;CYCP2Phatr;CYCH1Phatr;CYCL1Phatr;CYCD1Phatr;CYCA/B;1Arath;SDSPhatr;CYC-likeThap ... Yamaguchi M, Fabian T, Sauter M, Bhalerao RP, Schrader J, Sandberg G, Umeda M, Uchimiya H: Activation of CDK-activating kinase is dependent on interaction with H-type cyclins in plants. Plant ... Cip/Kip family in animals [51], or Kip-related proteins and SIAMESE pro-teins in plants [52,53]. CKIs are mainly low-molecular-weight proteins that inhibit CDK activity by tight associa-tion in...
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Báo cáo y học: " Estimating the impact of expanded access to antiretroviral therapy on maternal, paternal and double orphans in sub-Saharan Africa, 2009-2020" ppt
... of maternal,patern al and dual AIDS orphans in each country at year2020 following varying sc enarios of ART uptake. Mater-nal and paternal AIDS orphans were defined as childrenunder the age ... of AI DS orphans incurred in Scenario 1 (Universal ART uptake) and Scenario 2 (Sustaining current rate of ARTaccess) in 10 Sub-Saharan African countries by year 2020.Anema et al. AIDS Research ... antiretroviral therapy on maternal, paternal and doubleorphans in sub-Saharan Africa, 2009-2020. AIDS Research and Therapy2011 8:13.Submit your next manuscript to BioMed Central and take full advantage...
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Báo cáo y học: "Threshold for detection of diabetic peripheral sensory neuropathy using a range of research grade monofilaments in persons with Type 2 diabetes mellitu" pot
... weretested by one way analysis of variance (ANOVA). Mono-filament data were deemed to be ordinal and statisticalanalysis was performed using the Jonckheere-Terpstra (J-T) test, a non-parametric test ... peripheral neu-ropathy or impaired nerve responses, cancer therapy(current or in the past five years), myocardial infarction,angioplasty or bypass graft, rheumatoid arthritis, alcohol-ism, history ... Essential Facts ScotiaPharmaceuticals Ltd; 1997. 3. Franklin GM, Kahn LB, Baxter J, Marshall JA, Hamman RF: Sensoryneuropathy in non-insulin-dependent diabetes mellitus. TheSan Luis Valley Diabetes...
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Báo cáo y học: " Large infrapatellar ganglionic cyst of the knee fat pad: a case report and review of the literature" potx
... upon local pal-pation.TheresultsofLachman-Noulis,Apley ,and McMurray tests were negative, and X-rays showed nobony abnormalities. Initially, our predominant diagnosiswas medial meniscal cyst.* ... Krinas2, Dimitris Kipriadis2, Apostolos Ilias2, Andreas Giannakopoulos2 and Stephanos Kalos2AbstractIntroduction: Large ganglionic cystic formations arising from the infrapatellar fat ... ganglion a jelly-like consistency, and is lined with a pseudomembrane.Gangliaaboutthekneearerareandusuallyarelocated within the joint, in juxtaposition to the joint, or in the soft tissues around...
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Báo cáo y học: "Anti-glomerular basement membrane disease superimposed on membranous nephropathy: a case report and review of the literature" pdf
... improvement in his renal function. He is being maintained on hemodia-lysis after six months following his initial presentation.He is currently awaiting kidney transplantation.DiscussionThis case ... literature that have been associated with a high mortality and morbidity, and a very high rate of renal failure resulting in hemodialysis. Co-existence ofmembranous nephropathy and anti-glomerular ... non-steroidal anti-inflammatory agents. He believedthat he had received a blood transfusion during theVietnam War secondary to bleeding after a forearminjury. Physical examination revealed that his...
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Báo cáo y học: "Anti-glomerular basement membrane disease superimposed on membranous nephropathy: a case report and review of the literature" ppt
... formation in anti-GBM disease, increasing antigen synthesis by injured podocytes and facilitated by the capping and shedding of antigen-antibody complexes into the sube-pithelial space. Alternatively, ... design, acquisition,analysis and interpretation of data. NN and AT were involved in drafting themanuscript or revising it critically for important intellectual content. Allauthors read and approved ... anti-glomerular basement membrane disease and membranous nephropathy is rare.Case presentation: A 59-year-old Hispanic man presented with acute onset of nausea and vomiting and wasfound to have renal insufficiency....
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