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Báo cáo y học: "Identification of citrullinated α-enolase as a candidate autoantigen in rheumatoid arthritis" doc

Báo cáo y học:

Báo cáo y học: "Identification of citrullinated α-enolase as a candidate autoantigen in rheumatoid arthritis" doc

... implicates citrullinated α-enolase as a candidate autoantigen that could drive the chronic inflammatoryresponse in RA.Introduction Rheumatoid arthritis (RA) is a common and disabling diseaseaffecting ... Sugaya M, Hanagiri T, Yasumoto K: [Tumor marker in primary lung cancer]. J UOEH 2004, 26:473-479.38. Suzuki A, Yamada R, Chang X, Tokuhiro S, Sawada T, Suzuki M,Nagasaki M, Nakayama-Hamada M, ... immunoblotting. This suggests that citrullinated α-enolase is at least as immunodominant as citrullinated filag-grin or citrullinated vimentin, because, by immunoblotting, thefrequency of antibodies against...
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Báo cáo y học: "Stress of different types increases the proinflammatory load in rheumatoid arthritis" docx

... steadilyincreases, and today we can say that patients with chronicinflammatory diseases such as rheumatoid arthritis (RA) showabnormal stress responses leading to proinflammatoryconsequences.Stress can ... importantand original aspect of the work of Edwards and colleagues isthe fact that pain testing increased serum levels of TNF,which was not demonstrated in healthy control individuals.The increase ... (in cell culture experiments) of proinflammatory cytokines(Table 1). Since stress in healthy subjects can lead to anincrease of serum cytokines [3], a comparison of patientswith RA and healthy...
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Báo cáo Y học: Characterization of selenoprotein P as a selenium supply protein docx

Báo cáo Y học: Characterization of selenoprotein P as a selenium supply protein docx

... recombinant human insulin andhuman transferrin from Wako, Osaka, Japan; and nickel-nitrilotriacetic acid agarose from Qiagen Inc., Chatsworth,CA, USA. Recombinant human thioredoxin was kindlyCorrespondence ... 2002Characterization of selenoprotein P as a selenium supply proteinYoshiro Saito* and Kazuhiko TakahashiDepartment of Hygienic Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido ... various tissues requiring iron [41]. Albumin is believed tosupply many low-molecular-mass substances such as metals,amino acids and fatty acids [42]. Transferrin and albuminnoncovalently bind...
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Báo cáo y học: "α α Upregulated hypoxia inducible factor-1α and -2α pathway in rheumatoid arthritis and osteoarthritis" pps

... (VEGF) and platelet-derived endothelial cellgrowth factor (PD-ECGF; also known as thymidine phos-phorylase) and, as a consequence, an increasedAPAAP = alkaline phosphatase/antialkaline phosphatase; ... 95:7987-7992.23. Mazure NM, Chen EY, Laderoute KR, Giaccia AJ: Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed ... expression was diffuse in the fibroblasts of both RAand OA. Normal material was either negative or focallyweak. PD-ECGF expression was diffuse in all cases of RA,but such reactivity was either focal...
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Báo cáo y học: "Anti-tumour necrosis factor therapy and B cells in rheumatoid arthritis" pptx

... TNF and a related cytokine, lympho-toxin alfa (LTα), also play an important role in the develop-ment and homeostasis of secondary lymphoid organs [8].Studies in mice suggest that TNF plays a ... unclear what effects anti-TNF treatment can have onB cells in RA and whether any effects influence the efficacy of these agents. In patients with RA, anti-TNF agents sometimescan induce a sustained ... general,TNF and soluble LTα are thought to have overlapping roles in this setting, although LTα may play a predominant role in promoting the formation of tertiary lymphoid tissue at sites of chronic...
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Báo cáo y học: "Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial" pot

... circulating adiponectin may beinvolved in cardiovascular disease in RA patients. Althoughthis contradiction was partly explained by the induction of tol-erance to inflammatory stimuli by adiponectin ... Sata M, Arita Y, Nishida M, Maeda N,Kumada M, Okamoto Y, Nagaretani H, Nishizawa H, Kishida K,Komuro R, Ouchi N, Kihara S, Nagal R, Funahashi T, Matsuzawa Y: Role of adiponectin in preventing ... significantly affected by the stage of disease than otherfactors, such as cytokines. MMP-9 level was increased more in early stages of arthritis than in later stages [30]. Thus, thelevel of MMPs in...
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Báo cáo y học: "Identification of novel citrullinated autoantigens of synovium in rheumatoid arthritis using a proteomic approach" pdf

... Sawada T, Suzuki M,Nagasaki M, Nakayama-Hamada M, Kawaida R, Ono M, et al.:Functional haplotypes of PADI4, encoding citrullinatingenzyme peptidylarginine deiminase 4, are associated with rheumatoid ... K,Ochiai A, Hirohata S, Shimizu M, Watanabe Y: High diagnosticvalue of anticalpastatin autoantibodies in rheumatoid arthritisdetected by ELISA using human erythrocyte calpastatin as antigen. ... Sugao 2-16-1, Miyamae, Kawasaki, Kanagawa 216-8512, Japan2Musculoskeletal Science, Yokohama City University Graduate School of Medicine, Fukuura3-9, Kanazawa, Yokohama, Kanagawa 236-0004, Japan3Department...
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Báo cáo y học: "Identification of clinical and simple laboratory variables predicting responsible gastrointestinal lesions in patients with iron deficiency anemia"

... identified 1 gastric and 1 colon cancer patient in our study. An early gastric cancer was di-agnosed on biopsy of a suspicious ulcerated area in a 45-year-old man patient. Partial gastrectomy was su ... ccessful and rema ins w el l. An 82 -year-old man was diagnosed adenocarcinoma by endoscopic biopsy. A right hemicolectomy was performed, and the patient had no any metastasis. Three years after ... Identification of clinical and simple laboratory variables predicting re-sponsible gastrointestinal lesions in patients with iron deficiency anemia Songul Serefhanoglu , Yahya Buyukasik, Hakan...
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Báo cáo y học: "Identification of Cellular Membrane Proteins Interacting with Hepatitis B Surface Antigen using Yeast Split-Ubiquitin System"

... amplified by PCR using full length HBV DNA (adw2 serotype) as the template. The oligonucleotide primers were designed as follows: 5’-TTAGGCCTAAAAATGGAGAACATCACATCAGGA-3’ 5’-AAAACAGAGACCCATATGTAAATTGGTACCAATT-3’ ... Construction of cDNA Library in S. cerevisiae DSY-2 Strain The cDNA library was prepared by transforming the yeast S. cerevisiae DSY-2 strain, in which the cDNA mixture was combined with pDL2-XN ... termination of transcription at its 3’ end [9]. The ability of this genome in behaving as a replicative virus after its transfection in HepG2 cells was then measured by the amount of HBsAg particles...
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Báo cáo y học: "Identification of subpopulations with characteristics of mesenchymal progenitor cells from human osteoarthritic cartilage using triple staining for cell surface markers" docx

... Köln, Germany) were used. Theantibody directed against collagen type I was diluted1:1000, the antibody against collagen type II was diluted1:400, and the antibody against COMP was used at a 1:300 ... roles in joint physiology and disease, as well as in induction of regenerative processes withinosteoarthritic joints.MethodsPatient characteristicsHuman osteoarthritic cartilage (OC) was obtained ... 5'-ACC TCG TTG ACA CCT GGA AG-3'5'-CCA CCA TCT CGG AGA GTG AC-3'BSP 5'-TGC ATT GGC TCC AGT GAC ACT-3'5'-TGC TCA GCA TTT TGG GAA T-3'Col1 5'-TAA...
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