... Saijo S, Tanioka H, Nakae S, Sudo K, Okahara A, Ikuse T,Asano M, Iwakura Y: Development of chronic inflammatoryarthropathy resembling rheumatoid arthritis in interleukin 1receptor antagonist-deficient ... 27Available online http://arthritis-research.com/content/6/1/26known roles in tissue inflammation, and damage in innateimmunity. Besides its capacity to drive the production ofIFN-γ and ... responsemechanism and the environmental exposure history, foreach individual, govern the risk of autoimmune diseasemanifestation. Finally, the mandatory contribution ofsignals other than antigen...