Báo cáo y học: "ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis" pdf
Báo cáo y học: "ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis" pdf
... defined in the MEROPSdatabase [5,6] and are structurally and evolutionarily relatedto the ADAM (a disintegrin and metalloproteinase; also partof the adamalysin subfamily) enzymes and, more distantly, ... representation of the minimal domain organisation of matrix metalloproteinase (MMP), ADAM (a disintegrin and metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs; ... [4] and have subsequently beenidentified in mammals and Caenorhabditis elegans. They formpart of subfamily B (adamalysin subfamily), family M12, in clanMA of the metallopeptidases, as defined...
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Báo cáo y học: " Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis"
... Acad Sci USA 2006; 103(39): 14584-14589. 16. Yamaguchi H, Sasaki K, Satomi Y, Shimbara T, Kageyama H, Mondal MS, Toshinai K, Date Y, Gonzalez LJ, Shioda S, Takao T, Nakazato M, Minamino N. Peptidomic ... Chakraborty TR, Tkalych O, Nanno D, Garcia AL, Devi LA, Salton SR. Quantification of Vgf- and pro-SAAS-derived pep-tides in endocrine tissues and the brain, and their regulation by diet and ... Biotech, CA). The assay was developed using a stabilized HRP substrate. All samples were analyzed in the linear range of the ELISA using over-expressed human Vgf as a standard. Assessment...
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Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx
... membrane was treated with a rabbit anti-iNOS polyclonal antibody or rabbit anti-PKCpolyclonal antibody at 1 : 1000 dilution and anti-(rabbitIgG) Ig horseradish peroxidase conjugated antibody at1 ... [27]. Nitrite diazotiates the aryl amine, and thenthe diazotiated product forms an azochromophore bycoupling with naphthyl-ethylenediamine. Absorbance wasmeasured at 550 nm in a Shimadzu UV-1600 ... NOproduction, indicating that TS activated a LPS-stimulatedsignal pathway (Fig. 4). PKC is a key kinase in the LPS-stimulated signal pathway [30,31]. The findings that PKCinhibitors, not PKA inhibitors,...
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Báo cáo Y học: Dystrobrevin requires a dystrophin-binding domain to function in Caenorhabditis elegans doc
... 4. Yeast two-hybrid assay. A plate containing SD media minusleucin, t ryp tophan and histidine was seeded with yeast c arrying DNA-BD-Dys-1 and various AD-Dyb-1 p lasmids or empty pACT2 (as a negative ... explain the physiopathology ofthe disease, and may also provide therapeutic clues.Dystrobrevins form a family of proteins that are uniqu e in that they are both dystrophin-associated proteins, ... theirmammalian counterparts [12], and they also bind tosyntrophin [18]. dys-1 and dyb-1 mutants d isplay a similarbehavioural phenotype c onsisting of hyperactivity, exagger-ated bending of...
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Báo cáo y học: "Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study" pdf
... the X /Y allele was also determined by studying six'extended' genotype groups: YA/YA, YA/XA, XA/XA, YA/O,XA/O and O/O.Statistical analysisData are presented as median and IQR because ... are seen in individuals with the genotypesXA/XA and YA/O, whereas very low or undetectable serumMBL levels are seen in individuals with genotypes XA/O and O/O. Individuals with YA/YA and YA/XA ... study of 218 patients with polyarthritis (n = 67) and oligoarthritis (n = 151), clinical and laboratory disease variables were obtained by clinicalexamination and chart reviews. Healthy Caucasian...
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Báo cáo y học: "Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer" pdf
... bioinformatic analysis of array data. OP performed the breakpoint sequencing and analyzed the data. MT generated mate-pair libraries. IR performed SOLiD sequencing and generated fragment libraries. ... calling was done using a custom analysis pipeline that identifies mutations with a non-reference allele frequency larger than 15% and a coverage of at least 10x. Sequencing data are available ... healthy samples. SNP-array data were submitted to the NCBI GEO archive and are available under accession number GSE32711. Mutational profiling Mutational analysis of 1296 kinases and cancer-related...
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Báo cáo y học: "Kbus/Idr, a mutant mouse strain with skeletal abnormalities and hypophosphatemia: Identification as an allele of ‘Hyp’" pdf
... Otolaryn 1997, 117:20-24.2. Yonezawa S, Yoshizaki N, Kageyama T, Takahashi T, Sano M, Tokita Y, Masaki1 S, Inaguma Y, Hanai A, Sakurai N, Yoshiki A, Kusakabe M,Moriyama A, Nakayama A: Fates ... familial X-linked hypophosphatemic rickets. Eur J Pediatr2004, 163:622-623.46. Yamazaki Y, Okazaki R, Shibata M, Hasegawa Y, Satoh K, Tajima T,Takeuchi Y, Fujita T, Nakahara K, Yamashita T, Fukumoto ... RESEARCH Open AccessKbus/Idr, a mutant mouse strain with skeletalabnormalities and hypophosphatemia:Identification as an allele of ‘Hyp’Kenji Moriyama1*, Atsuko Hanai2, Kazuyuki Mekada3,...
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Báo cáo khoa học: "Case of a sigmoid colon cancer with metachronous metastases to the mesorectum and the abdominal wall" pdf
... sporadicreports also to the spleen, stomach, thyroid gland, abdominal wall and upper urinary tract. This is a rare case ofmetachronous metastases invading the mesorectum and the abdominal wall.Case presentation: ... Zizi-Sermpetzoglou, Athanasios Marinis, Andrea s Hadjimarcou,Nikolaos Paschalidis, Spyros RizosAbstractBackround: Sigmoid colon cancer metachronous metastases commonly occur in the liver and lungs with sporadicreports ... rectum examination one yearlater a palpable extramucosal mass was noticed at theanterior rectum wall. An abdominal CT scan revealed a tumor 2 cm in size at the lower anterior mesorectum in close...
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Báo cáo y học: "Peroxisome proliferator-activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1β in articular chondrocytes" doc
... used: PPARγ1 sense, 5'-AAA-GAAGCCAACACTAAACC-3'; PPARγ2 sense, 5'-GCGAT-TCCTTCACTGATAC-3'; common PPARγ1 and PPARγ2antisense, 5'-CTTCCATTACGGAGAGATCC-3'; glyceralde-hyde-3-phosphate ... tempting to speculate that diminished expressionof PPARγ in OA cartilage may, at least in part, be involved in increased expression of inflammatory and catabolic genes,promoting articular inflammation ... immunohistochemical analysis.We found that chondrocytes in both normal and OA cartilageexpress PPARγ protein. The immunostaining for PPARγ wasessentially located in the superficial zones, and was lower in OA...
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Báo cáo y học: "The epidemiology of medical emergency contacts outside hospitals in Norway - a prospective population based study"
... Grønlien, and Jan Nystuen from the area of Innlandet, Unni Eskeland and Olav Østebøfrom the area of Stavanger, and Leif Landa, Kari Hauge Nilsen, and TrondKibsgaard in the area of Haugesund. We want ... Acute vital (life threatening) dangerNACA 6 Acute cardiac or respiratory arrestNACA 7 DeathZakariassen et al. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2010, 18:9http://www.sjtrem.com/content/18/1/9Page ... hospitalisation, butstill not a life-threatening situation. NACA 4-6 indi-cates potentially (4) and definitely life-threateningmedical situations (5 and 6) and NACA 7 is a deadperson. NACA scores...
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