Báo cáo y học: "Cold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertension" ppt
Báo cáo y học: "Cold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertension" ppt
... at1 year and 2 years of 96% and 89% compared withViewpointCold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertensionFrances C HallUniversity of ... processesunderlying RP and PAH contribute to the familiar pattern of skin, renal and gastrointestinal pathology. The emergence of effective and conveniently administered therapy for PAHincreases the importance ... cell dysfunction is characterised bydecreased production of the vasodilators nitric oxide and prostacyclin, and by enhanced release of endothelin-1.Endothelial cell dysfunction influences the...
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Báo cáo y học: " Chemokine blockade: a new era in the treatment of rheumatoid arthritis" ppsx
... of a variety of inflammatory chemokines and their receptors [5,6]. In vitrostudies have suggested that both so-called homeostaticchemokines and inflammatory chemokines, including CCchemokine ... selectively [20]. In that study a highly specific neutralizing antibody againstIL-8 was administered in several types of acuteinflammatory disease, including lipopolysaccharide/IL-1induced arthritis. ... chemokines canstimulate cells to release (pro)inflammatory mediators suchas cytokines and matrix metalloproteinases [3]. Increasedexpression of inflammatory chemokines has been found in many inflammatory...
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Báo cáo y học: "Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity" pdf
... correlationbetween MMP activity (evidenced by the 342FFGVG-G2 and CTX biochemical markers) and the inability of cytokine-treatedchondrocytes to initiate and/ or maintain anabolic activity.Switching to anabolic ... generated by an array of MMPs, of which MMP-2 and MMP-9 are only a subset. Onother occasions, the presence of these gelatinases has beena valid indication of total MMP activity and thereby the cata-bolic ... synthesis in cartilage explants was measured by the concentration of N-terminal pro-peptides of type II collagen in the condi-tioned medium using the PIINP enzyme-linked immunosorbent assay...
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Báo cáo y học: "AIT test has no problem in the detection of anti-ribosomal P" ppsx
... qualitycontrol program run by the Korean Society of LaboratoryMedicine [3]. In 1999 and 2007, reports of antinuclearantibody test using the IT-1 cell line on 208 and 588systemic lupus erythematosus ... commercialized and passed inspection by the Korea Food and Drug Administration in South Korea.Currently, IT-1 is being used under the name of the autoimmune target (AIT) test and it participates in the ... anti-ribosomal P (anti-Rib-P) in the pictures they revealed. In addition to the anti-Rib-P that Mahler and colleagues mentioned, limitations of the HEp-2 cell line in the detection of autoantibodies such...
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Báo cáo y học: " AIT test has no problem in the detection of anti-ribosomal P – authors’ response" docx
... systematic study is mandatory to compare the sensitivity and specificity of the AIT test for the detection of anti-Rib-Pantibodies and other antibody specificities using a variety of contemporary diagnostic ... assay, and then used these sera to determine the positivity and stainingpatterns in the AIT test. This method raises concernsbecause it is generally known that immunodiffusion is arelatively insensitive ... Despite the clearance of the AIT test by the South Korea Food and Drug Administration, to the best of our knowledge this test is not widely used as ascreening method – neither is it approved by the...
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Báo cáo y học: "Heel raises versus prefabricated orthoses in the treatment of posterior heel pain associated with calcaneal apophysitis (Sever’s Disease): study protocol for a randomised controlled trial" ppt
... secondarygrowth plate of the calcaneus. The calcaneal growth cen-tre or apophysis appears at approximately seven years of age [4] and fuses in girls of age approximately thirteenyears and boys of ... for the first time. The outcomes of this trial aretherefore likely t o strongly influence practice guidelines and clinical care in this area.This trial will be limited by its inability to blind ... in anydomain is 7 points and that based on previous work, the maximum standard deviation in any do main is 6 points[36]. Given this experiment has 1 pre-interventi on mea-sure and 3 post-intervention...
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Báo cáo y học: "Acute liver toxicity with ifosfamide in the treatment of sarcoma: a case report" doc
... vascularinjury [6]. While certain drugs are known to cause spe-cific types of injury, the type of injury in idiosyncraticdrug reactions can be of variable morphology. A liverbiopsy can be ... elucidate the mechanism of idiosyncratic hepatotoxicity. The main treatment of drug-induced liver toxicity iswithdrawal of the offending agent. Most patients recovercompletely; therefore, management ... co-administeredwith the chemotherapy regimen were dexamethasone,ondansetron and metoclopramide as anti-emetics and mesna for the prevention of urothelial toxicity.Within 24 hours of completing the...
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Báo cáo y học: " Sustained favorable long-term outcome in the treatment of schizophrenia: a 3-year prospective observational study" ppsx
... judgment and insight, stereotyped thinking, and poor attention items of the scalePsychosis SCAP-HQ Bothered much by feeling that others are spying against you or plotting against you,hearing voices ... between them and their family, and the protection they haveagainst being robbed or attackedSatisfaction with social life SCAP-HQ Combines the patient’s feeling about the way they spend their ... identified(Table 2) in the first step of the analysis and labeledfrom the “best” to “worst” cluster, with severity of symp-toms and level of functioning influenc ing cluster order. The majority of patients...
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Báo cáo y học: " A patient with superior semicircular canal dehiscence presenting with Tullio''''s phenomenon: a case report" pptx
... exploring the clinicalpresentation, investigation and management of the disor-der. The incidence of dehiscent bone has been reported in cadaveric analysis to lie between 0.4 and 0.5%, with thin-ning ... thin-ning of the bone to <0.1 mm in a further 1.4% [2].Symptoms include one or more of the following: soundinduced vertigo, often in a vertical-torsional plane; con-ductive hyperacusis; and ... http://www.jmedicalcasereports.com/content/3/1/22Page 3 of 3(page number not for citation purposes)2. Carey JP, Minor LB, Nager GT: Dehiscence or thinning ofthebone overlying the superior semicircular canal in a temporalbone survey. Arch...
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Báo cáo y học: "Silencing CD36 gene expression results in the inhibition of latent-TGF-β1 activation and suppression of silica-induced lung fibrosis in the rat" pdf
... on CD36 in the lungs of Quantity of TGF-β1 and the percentage of active TGF-β1 in BALFFigure 2Quantity of TGF-β1 and the percentage of active TGF-β1 in BALF. (A–a) The quantity of total and active ... could reduce hydroxyproline content in lungHydroxyproline content is an important indicator of lungfibrosis. In this study, no significant differences in the hydroxyproline content of the four treatment ... activation by Lv-shCD36 in BALF The activation of L-TGF-β1 was determined by detecting the quantity of TGF-β1 in BALF using the CCL-64 growthinhibition assay. The quantities of total TGF-β1 and activeTGF-β1...
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