... precursor by metalloproteinases. Nature1994, 370:555-557.38. Yoshihara Y, Nakamura H, Obata K, Yamada H, Hayakawa T,Fujikawa K, Okada Y: Matrix metalloproteinases and tissueinhibitors of metalloproteinases ... the synovium of chronicarthritis patients. J Immunol 2001, 166:650-655.48. Tsubaki T, Takegawa S, Hanamoto H, Arita N, Kamogawa J,Yamamoto H, Takubo N, Nakata S, Yamada K, Yamamoto S,Yoshie ... long-standing disease, so this abnormality wouldseem to be an integral feature of RA, independent of disease duration. Preliminary assessment of a group of patients withvery early RA, who had disease...